Frequency of Systemic Diseases and Medication Intake by Patients Referred to the Department of Oral Medicine of Hamadan Dental School

Objectives Due to advances in knowledge and treatment of diseases, life expectancy has increased worldwide. This study aimed to determine the prevalence of systemic diseases and medication intake by dental patients referred to dental clinic of Hamadan Dental School.Methods A total of 800 patients referred to the Department of Oral Medicine from October 2013 to May 2014 were studied. The data extracted from patient charts included demographic data, systemic diseases, and medication intake, which were analyzed using the Chi-square test and Fisher’s exact test with SPSS version 16.0.Results Of all, 28.8% of participants were males and 71.2% were females. The mean age of participants was 32.3 years. The total prevalence of systemic diseases was 30.5%. The most common condition was endocrine diseases. The total prevalence of medication intake was 20% and the most common medications taken were supplements and antihypertensive medications.Conclusion The results of the present study showed that systemic diseases were prevalent in dental patients. Dentists and dental students must take a precise medical and medication history from patients before starting any dental procedure to prevent medical emergencie

Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach

Background. Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. Negative regulation of MAPK3 expression using miRNAs has led to therapeutic effects in cancer. Objectives. The present study performed molecular docking and dynamics simulation to identify potential MAPK3 inhibitors from natural flavonoids, possibly leading to drug development in cancer therapy. Methods. A computational drug discovery approach was performed using the AutoDock tool to identify potential MAPK3 inhibitors from 46 plant-based flavonoids. A cross-validation study was executed using the Schrödinger Maestro docking tool. Molecular dynamics (MD) was executed to evaluate the stability of docked poses between the top-ranked compounds and the MAPK3 catalytic domain. Interactions among the most potent MAPK3 inhibitors and residues within the receptor’s active site were studied using the BIOVIA Discovery Studio Visualizer before and after 100 ns MD simulations. Results. Kaempferol 3-rutinoside-4′-glucoside, kaempferol 3-rutinoside-7-sophoroside, rutin, and vicenin-2 exhibited a magnificent binding affinity to the receptor’s active site. In addition, the stability of the docked poses of these compounds seemed to be stable after ∼45 ns computer simulations. Conclusion. The present study suggests that kaempferol 3-rutinoside-4′-glucoside, kaempferol 3-rutinoside-7-sophoroside, rutin, and vicenin-2 could strongly bind to the MAPK3 catalytic site and could be assigned as a potent inhibitor for MAPK3. These findings may be helpful in the treatment of various cancers. However, further validation experiments are needed