8 research outputs found

    The rate ratios (RR) of the excess mortality in patients with psychotic disorders (PD) comorbid with psychoactive substance use disorders (PSD) compared to patients with PDs without PSDs by gender and cause-of-death groups in the periods 1996–98 and 2008–10 in Finland.

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    <p>(a) The alcohol-related mortality RR was 5.70 (95% confidence interval 1.46–22.26) in the period 1996–98 and 11.44 (95% CI 3.81–34.22) in the period 2008–10. (b) The alcohol-related mortality RR was 22.87 (95% CI 3.18–164.66) in the period 1996–98 and 11.36 (95% CI 2.64–48.84) in the period 2008–10. Significant RRs indicated as *. The data for Fig 3 in addition to the data for the other study periods and all 95% confidence intervals are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152223#pone.0152223.s004" target="_blank">S4 Dataset</a>.</p

    The rate ratios (RR) of the excess mortality in patients with severe mental disorders (SMD) compared to the total population by gender, cause-of-death groups, and the SMD categories (patients with psychotic disorders [PD], psychoactive substance use disorders [PSD], and mood disorders [MD]) in the periods 1996–98 and 2008–10 in Finland.

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    <p>(A) The alcohol-related mortality RR was 15.18 (95% confidence interval 12.16–18.96) in the period 1996–98 and 13.30 (95% CI 11.28–15.69) in the period 2008–10. (B) The alcohol-related mortality RR was 54.79 (95% CI 34.22–87.71) in the period 1996–98 and 35.78 (95% CI 25.76–49.71) in the period 2008–10. Non-significant RRs indicated as NS. The data for Fig 2 in addition to the data for the other study periods and all 95% confidence intervals are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152223#pone.0152223.s002" target="_blank">S2 Dataset</a>.</p

    Number of person years (py) for the total population and for patients with severe mental disorders (SMD), non-institutionalised and aged 25–74, the proportion of patients with SMDs by hierarchical categories (patients with psychotic disorders [PD], psychoactive substance use disorders [PSD] or mood disorders [MD]), and the proportion of patients with hospitalisations due to PSDs by gender in 1996 and 2010 in Finland.

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    <p>Number of person years (py) for the total population and for patients with severe mental disorders (SMD), non-institutionalised and aged 25–74, the proportion of patients with SMDs by hierarchical categories (patients with psychotic disorders [PD], psychoactive substance use disorders [PSD] or mood disorders [MD]), and the proportion of patients with hospitalisations due to PSDs by gender in 1996 and 2010 in Finland.</p

    Age-standardised mortality rates (/100 000 person years) among the total population and patients with severe mental disorders (SMD) by gender and cause-of-death groups for the period 1996–2010 in Finland.

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    <p>The data for Fig 1 are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0152223#pone.0152223.s001" target="_blank">S1 Dataset</a>.</p

    Telomere length is affected by childhood adverse life events but not by anxiety disorder diagnosis or recent psychological stress.

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    1<p>Difference in standardized telomere length for one unit or category change in each independent variable.</p>2<p>Standard error of the mean.</p>3<p>Sum score of the 12-item General Health Questionnaire.</p>4<p>Categorized to 0 adversities, 1 adversity, 2 or 3 adversities, and 4 or more adversities.</p><p>Results from three independent regression models are shown in which sex and age adjusted telomere length was explained by either anxiety disorder status, GHQ-12 score, or number of childhood adversities.</p

    Telomere length as a function of age.

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    <p>Anxiety disorder core and subthreshold cases (N = 321) are shown with red dots and controls (N = 653) with blue dots, each dot representing one individual. Regression lines for both groups are shown with the same color coding.</p
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