Multivariate associations between arsenic metabolites and genotyped SNPs in the 10q24.32 region showing the strongest univariate associations with DMA% and MMA% (n = 1,313).

<p>Regression models including all five SNPs in a single model, adjusting for age, sex, and water arsenic. All regressions were mixed models carried out using EMMAX.</p>a<p>MA, minor allele.</p>b<p>MAF, minor allele frequency.</p

Association between the 10q24.32 genotyped variants and arsenical skin lesion risk and SNP-arsenic interaction estimates.

a<p>MA, minor allele.</p>b<p>Each Logistic Regression model includes one SNP, adjusting for age and sex.</p>c<p>The ROADTRIPS case-control test does not allow multivariate modeling (i.e., no adjustments), but accounts for cryptic relatedness.</p>d<p>Interaction P-values are from mixed linear models that account for relatedness among subjects. Interactions are on the additive scale and are calculated using data on 69 cases and incident 700 controls.</p

Multiple variants in the 10q24.32 region show independent associations with DMA% (n = 1,313).

<p>P-values were generated using mixed models adjusted for age, sex, and water arsenic concentration. The strongest associated SNP is labeled in each panel. Panel A shows the overall association results. Panel B shows P-values from models that are adjusted for rs9527. Panel C shows P-values from models adjusted for both rs9527 and rs11191527.</p

Multiple variants in the 10q24.32 region show independent associations with MMA% (n = 1,313).

<p>P-values were generated using mixed models adjusted for age, sex, and water arsenic concentration. The strongest associated SNP is labeled in each panel. Panel A shows the overall association results. Panel B shows P-values from models that are adjusted for rs4919694. Panel C shows P-values from models adjusted for both rs4919694 and rs4290163.</p