POLICY AND PRACTICE TARGETING THE LABOUR MARKET INTEGRATION OF NON-EU NATIONALS IN IRELAND. ESRI RESEARCH SERIES NUMBER 89 JUNE 2019

Increases in immigration inflows to both the European Union (EU) and Ireland between 2014 and 2016, due in part to the ‘refugee and migrant crisis’, have resulted in an increased focus on integration policies, outcomes and measures, including in the area of labour market integration. Employment is crucial for the integration of migrants into the economic and social life of their host country, so labour market integration is a very important part of integration policy (European Commission, 2016). In recent years, many Member States have updated existing labour market integration policies or have developed new ones. Ireland, like the majority of EU Member States (EMN, 2019), pursues a policy of mainstreaming service provision in the area of integration, with targeted initiatives to meet specific needs. This study first considers labour migration policy, which manages and shapes overall access of non-European Economic Area (EEA) nationals to the Irish labour market.1 Under the employment permits system administered by the Department of Business, Enterprise and Innovation (DBEI), non-EEA nationals may apply to access the Irish labour market. The report then looks at specific policies and measures which aim to improve labour market integration for non-EU nationals living in Ireland. The focus is on labour integration measures for regularly staying non-EU nationals with a right to work. Measures specifically targeting non-EEA students, graduates, asylum seekers and beneficiaries of international protection are beyond the study scope. The effect of general labour market and social policy provision in Ireland on labour market integration is also outside the scope. Examples of public and private sector practices are discussed together with examples of community sector practices that receive public funds

Planning Strategically for Regional Development in the Permian Basin

The Survey Research Center and the Center for Economic Development at the University of North Texas were retained by the Permian Basin Regional Planning Commission to assist them in developing a strategic plan for the region

A-CD estrogens. I. substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds

Long-term use of estrogen supplements by women leads to an increased risk of breast and uterine cancers. Possible mechanisms include metabolism of estradiol and compounds related to tumor-initiating quinones, and ligand-induced activation of the estrogen receptors ERα and ERβ which can cause cancer cell proliferation, depending on the ratio of receptors present. One therapeutic goal would be to create a spectrum of compounds of variable potency for ERα and ERβ, which are resistant to quinone formation, and to determine an optimum point in this spectrum. We describe the synthesis, modeling, binding affinities, hormone potency, and a measure of quinone formation for a new family of A-CD estrogens, where the A-C bond is formed by ring coupling. Some substituents on the A-ring increase hormone potency, and one compound is much less quinone-forming than estradiol. These compounds span a wide range of receptor subtype selectivities and may be useful in hormone replacement therapy