15 research outputs found
Estado oxidativo celular em camundongos expostos cronicamente a efluentes de curtume submetidos à fotodegradação eletroquímica
02
Estado oxidativo celular em camundongos expostos cronicamente a efluentes de curtume submetidos à fotodegradação eletroquímica
02
Atividade antiinflamatória em processo inflamatório crônico dos extratos etanólicos de Cunila microcephala e Cymbopogon citratus
32
Antidepressant-like effects of methanol extract of Hibiscus tiliaceus flowers in mice
Background: Hibiscus tiliaceus L. (Malvaceae) is used in postpartum disorders. Our purpose was to examine the antidepressant, anxiolytic and sedative actions of the methanol extract of H. tiliaceus flowers using animal models. Methods: Adult male Swiss albino mice were treated with saline, standard drugs or methanol extract of H. tiliaceus and then subjected to behavioral tests. The forced swimming and tail suspension tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered. The animals were submitted to the elevated plus-maze and ketamine-induced sleeping time to assess anxiolytic and sedative activities, respectively. Results: Methanol extract of H. tiliaceus significantly decreased the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests. This extract did not potentiate the effect of ketamine-induced hypnosis, as determined by the time to onset and duration of sleeping time. Conclusion: Our results indicate an antidepressant-like profile of action for the extract of Hibiscus tiliaceus without sedative side effect
Antidepressant-like effects of methanol extract of Hibiscus tiliaceus flowers in mice
Background: Hibiscus tiliaceus L. (Malvaceae) is used in postpartum disorders. Our purpose was to examine the antidepressant, anxiolytic and sedative actions of the methanol extract of H. tiliaceus flowers using animal models. Methods: Adult male Swiss albino mice were treated with saline, standard drugs or methanol extract of H. tiliaceus and then subjected to behavioral tests. The forced swimming and tail suspension tests were used as predictive animal models of antidepressant activity, where the time of immobility was considered. The animals were submitted to the elevated plus-maze and ketamine-induced sleeping time to assess anxiolytic and sedative activities, respectively. Results: Methanol extract of H. tiliaceus significantly decreased the duration of immobility in both animal models of antidepressant activity, forced swimming and tail suspension tests. This extract did not potentiate the effect of ketamine-induced hypnosis, as determined by the time to onset and duration of sleeping time. Conclusion: Our results indicate an antidepressant-like profile of action for the extract of Hibiscus tiliaceus without sedative side effect
La Región: La Región - Epoca 2ª Año XIII Número 4403 - 1936 febrero 8 (08/02/1936)
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