Technical and Economic Evaluation of Pinavia Interchange in Comparison with Roundabout Intersection by AIMSUN

Interchanges that are investigated in this research are roundabout interchange and pinavia interchange that are simulated in AIMSUN software using traffic data. The parameters that  are considered for each interchange are  traffic volume, pollutant emissions, fuel consumption, travel time, delay time ,construction cost, repair and maintenance cost, travel time cost , fuel consumption cost and safety , so that in technical evaluation traffic volume, pollutant emissions, fuel consumption, travel time, delay time are compared  by using two independent sample t – test that are used  for comparing of two group of data and It is assumed that the variances are equal . Then In economic evaluation construction cost, repair and maintenance cost, travel time cost , fuel consumption cost and safety are converted into cost by using axis produce way that based on this supposal that storage in exchange for an hour of travel time, increase an hour of production opportunities and construction cost, repair and maintenance cost calculated by executive plans and Related Regulations and finally each parameter is weighted by AHP and obtain the universal (total) cost. Finally due to the total cost of the resulting it can be seen that for twenty-year period pinavia interchange in compare with roundabout interchange has 49% more efficient

Isolation, characterization and tolerance survey of bacterial strains to cadmium in soils receiving Hamadan industrial parks wastewater treatment plant effluent

Background and Aims: Biosorption is a relatively new clean up method used for the removal of heavy metals from the environment. Entry of heavy metals into the environment may result in change in population structure and further alteration of resistance mechanism(s) in exposed microorganisms. The first question inthis study sought to determine the threshold of bacterial resistance to cadmium (Cd). The second question was to identify indigenous bacterial species capable of removing the Cd from the soil and consequently to achieve a more efficient biological treatment for industrial effluents.Materials and Methods: Natural topsoil samples were obtained from three industrial parks in Hamadan, Iran. The concentration of Cd in soil samples was measured and thence the bacterial cultures were prepared. Following the screening process, the minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] were determined in order to find the threshold of bacterial tolerance. Indeed, theadsorption capacity of bacterial strains came down in favor of the identification of resistant bacteria.Results: Respectively, 42, 4 and 4 bacterial strains were identified for cultures having average cadmium concentrations of 0.78, 500 and 750 mg/L. This experiment did also detect that Tcd2 and Tcd4 showed the highest MIC with 1250 mg Cd/L. Moreover, TCd2, belonging to the family of Enterobacteriaceae and Enterobacter genus, demonstrated the maximum cadmium removal efficiency (30.2%).Conclusion: The test was successful as it was able to identify the indigenous cadmium tolerant bacteria with high adsorption capacity. This finding has important implications for developing special biological wastewater treatment such as a biofilter in the cadmium-releasing industries.Key words: Cadmium, Hamadan, Industrial park, Resistant bacteria, Soi

The Effect of Chronic Ethanol Consumption on Sexual Motivation and Behavior of Adult Male Wistar Rats in the Copulatory Phase

Background: The interaction of ethanol consumption and sexual behavior has been evaluated over the past three decades; however, some studies have assessed how ethanol consumption affects the general behavioral aspects of the copulatory cycle patterns in male rats. The aim of this study was to investigate the effect of chronic ethanol consumption on adult male Wistar rats' sexual motivation and behavior alteration in pre-copulatory, copulatory, and executive phases of the copulatory cycle. Methods: Male Wistar rats were randomly allocated to two groups (control and ethanol treated groups). After 42 days of treatment, male rats were given access to adult female rats for 2 hours and their sexual behavior were recorded in a fully dark room using an infrared camera. Findings: Chronic ethanol consumption caused a significant increase in anogenital sniffing and mounting, intermission, and ejaculation latencies periods, as well as a significant decrease in the sexual activity index (SAI) and copulatory efficiency (CE) compared to the control group. Conclusion: It is suggested that chronic ethanol consumption suppresses sexual behavior and reduces male rats' tendency toward sexual interaction with female rats as manifested by the enhanced latency periods in the copulatory phases and reduced SAI of ethanol treated animals

SEISMIC VULNERABILITY ASSESSMENT OF ELECTRIC POWER DISTRIBUTION NETWORK IN IRAN

ABSTRAC

Efficacy and tolerability of fourteen-day sequential quadruple regimen

The optimal pharmacological regimen for eradication of Helicobacter pylori (H. pylori) has been investigated for many years. This study aimed to evaluate the efficacy and tolerability of bismuth-based quadruple therapy (B-QT) and a modified sequential therapy (ST) regimens in eradication of H. pylori. A randomized, double-blind trial was conducted on 344 patients. Patients with H. pylori infection and without a history of previous treatment were randomized to receive 14-day B-QT (bismuth subcitrate 240 mg, pantoprazole 40 mg, amoxicillin 1000 mg, and clarithromycin 500 mg twice daily) or 14-day ST (bismuth subcitrate 240 mg, pantoprazole 40 mg, amoxicillin 1000 mg, and metronidazole 500 mg twice a day for seven days followed by bismuth subcitrate 240 mg, pantoprazole 40 mg, amoxicillin 1000 mg, and furazolidone 100 mg twice a day for additional seven days). Drug adverse effects were assessed during the study. H. pylori eradication was determined eight weeks after the end of treatment using 14C-urea breath test. Based on per-protocol and intention-to-treat, the eradication rate was significantly higher (p<0.05) in the B-QT regimen 91.9 % (95 % CI; 88.1-94.0) and 90.2 % (95 % CI; 86.3-92.9), respectively compared to the ST regimen 80.8 % (95 % CI; 76.6-84.9) and 78.1 % (95 % CI; 73.7-82.4), respectively. The severity of vomiting and loss of appetite were significantly higher in ST regimen (p<0.05). The B-QT regimen was more effective and safer than the ST regimen. Conclusively, it is suggested to assess the efficacy and safety of this regimen in longer studies, larger population, and in other communities

Oral and dental health in hospitalized psychiatric patients: a cross-sectional and comparative study in Kerman, Iran

Introduction: The purpose of this study was to assess oral and dental health of hospitalized psychiatric patients.Methods: This cross-sectional study which included 193 psychiatric patients was conducted in two psychiatric hospitals (Shahid Beheshti and Bahman) in Kerman, Iran. According to the duration of the hospital stay, patients were categorized into two groups of acute and chronic. The oral and dental health of the patients was assessed using Decay, Missing, Filling Teeth (DMF-T) index and Oral Assessment Guide for Psychiatric Care (OAG-PC). High score for these two scales indicated a worse oral and dental health.Results: Mean (±SD) DMFT and OAG-PC scores of the patients were 19.74 (±7.88) and 20.77, respectively. Univariate analysis showed that patients in chronic group had higher OAG-PC (P = 0.014), but the difference of DMF-T scores was not statistically significant between the two groups (P = 0.57). After controlling confounding variables, the differences of the DMF-T and OAG-PC scores were not statistically significant between the two groups (P values of 0.88 and 0.64, respectively).Conclusion: Oral and dental health in the studied psychiatric patients was poor. It is vital to improve the oral and dental health status of psychiatric patients

Relationship between Misconduct of Medical Professionalism with Burnout Syndrome and Related Factors

Background: Burnout syndrome (BOS) is a common occupational disease amongst medical physicians; especially anesthesiologists. BOS is known to result in increased expenditure of the healthcare system and decreased patient satisfaction. In order to substitute for good conduct by its medical staff, Tehran University of Medical University established its own guidelines on professionalism as a substitute for professional conduct amongst its personnel. Learning and practicing professionalism is not only a requirement to be competent as a specialist, but also it results in increasing healthcare quality and patient satisfaction. There is a lack of studies on the relationship between BOS and professionalism. Determination of the relationships between professionalism and BOS among TUMS anesthesiology residents. Methods: In this cross-sectional study all anesthesiology residents completed three forms (demographic checklist, Maslach Burnout Inventory (MBI), and professionalism self-conduct). The results were primarily analyzed using STATA 14.0 and relationships were established via linear and binary regression. Results: About 44 percent of residents met criteria for BOS. The risk of developing BOS was significantly higher for residents who adhered to the principles of respect and altruism and for residents training in one of our surveyed hospitals; whereas the risk of developing BOS would be reduced by increasing age and adherence to the principles of justice Burnout subscales scores concerning emotional exhaustion and personal accomplishment were significantly related with higher self-reported scores of altruism and honesty-integrity respectively. Conclusion: The chances of developing BOS could be enhanced by inadequate practice in the field of professional ethics. Therefor the importance of learning and competent practice of professionalism must be acknowledged. Age and professional climate were the most important demographic variables related to BOS in anesthesiology residents

Analysis of Methylation and Expression Profile of Foxp3 Gene in Patients with Behçet’s Syndrome

Forkhead box P3 (Foxp3) gene is an important means in the Treg cells function, in both maintenances of immune tolerance and regulation of response. Epigenetic modifications of the foxp3 gene at its regulatory regions control the chromatin accessibility for the transcription factors and other transcriptional regulators in order to control Foxp3 expression. In addition, the methylation status of CpG islands within the Foxp3 promoter and regulatory elements regulate the expression of Foxp3. This study was performed to assess the role of the foxp3 gene in patients with Behçet’s syndrome (BS). Venous blood samples were collected from all participants and peripheral blood mononuclear cells (PBMC) were extracted through Ficoll-Hypaque method. Genomic DNA was randomly sheared by sonication and immunoprecipitated with a monoclonal antibody. The status methylation of the foxp3 gene was estimated in 108 blood samples of active BS patients and healthy individuals (controls); using methylation DNA immunoprecipitation (MeDIP) technique. Expression analysis was carried out; using Real-time PCR. The expression of foxp3 gene in the patients' group (mean±SD: 1.79±1.12) was significantly lower than the healthy group (mean±SD: 2.73±1.33) (p<001). Also, the methylation levels of Foxp3 promoter showed that its level in patients (mean±SD: 2.3±1.16) was higher than the healthy group (mean±SD: 1.85±0.59). However, this increase was not statistically significant (p>0.05). Also, these results indicated that increasing the amount of methylation of the foxp3 gene by reducing its expression leads to an increase and intensifying of the disease. The decrease in Foxp3 expression is possibly associated with hypermethylation of the gene, and it can be considered as a risk factor for BS. Future studies may be needed to identify the capability of specific DNA methylation alterations in this syndrome

Doxorubicin-induced renal inflammation in rats: Protective role of Plantago major

Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced renal inflammation in rats. Materials and Methods: 80 male albino rats were randomly divided into 8 groups as follows: control, DXR, Ext (extract) 600, Ext1200, dexamethasone+DXR, vitamin E+DXR, Ext600+DXR, and Ext1200+DXR. Duration of the study was 35 days and DXR was intravenously injected on the 7th day of the experiment. Tumor necrosis factor-alpha (TNF-α) production and monocyte chemoattractant protein-1 (MCP-1) expression levels were assessed in the left kidney. Serum creatinine concentration and osmolarity were determined on the 1st, 14th, 21st, 28th and 35th days of the experiment. Results: DXR caused a significant increase in renal expression of MCP-1 and TNF-α production compared to control animals. Administration of dexamethasone, vitamin E and P. major extract significantly improved the expression of these inflammatory mediators compared to DXR group. Compared to day 1 in DXR group, serum osmolarity showed a significant increase on days 21, 28 and 35. Also, on these days, serum osmolarity in DXR group was significantly higher than that on the same days in control group. In Vit E+DXR and Ext 1200+DXR groups, there was no significant changes in serum osmolarity among different days of the study. However, in these groups, serum osmolarity on days 21, 28 and 35 showed a significant decrease compared to the same days in DXR group. Conclusion: Present results suggest that hydroethanolic extract of P. major protected renal tissue against DXR–induced renal inflammation

Factors Associated with The Incidence of Coronary Heart Disease in The Mashad: A Cohort Study

Coronary heart disease (CHD) is the leading cause of morbidity and mortality globally, and specifically in Iran. Accurate assessments of Coronary heart disease (CHD) incidence is very necessary for public health. In current study we aimed to investigate the incidence of CHD and importance of several classical, modifiable and un-modifiable risk factors for CHD among an urban population in eastern Iran after 6 years of follow-up. Methods The population of MASHAD cohort study were followed up for 6 years, every 3 years in two step by phone and who reported symptoms of CVD were asked to attend for a cardiac examination, to estimate the incidence of CHD with 95% confidence interval (95% CI) as well multiple logistic regression analysis was performed to assess the association of several baseline characteristics with incidence of CHD event. Evaluation of goodness-of-fit was done using ROC analysis. CHD cases divided into four different classes which include: stable angina, unstable angina pectoris, myocardial infarction and sudden cardiac death. Results In the six years\u27 follow-up of Mashhad study, the incidence rate of all CHD event in men and women in 100,000 people-years with 95% confidence intervals were 1920 (810-3030) and 1160 (730-1590), respectively. The areas under ROC curve (AUC), based on multivariate predictors of CHD outcome, was 0.7825. Conclusion Our findings indicated that the incidence rate of coronary heart diseases in MASHAD cohort study increases with age as well as our final model designed, was able to predict approximately 78% of CHD events in Iranian population