Estimated coverage compared with the first two 90 targets extrapolated to the total adult population.

<p>The red line shows the 90% target for first two of the 90-90-90 targets. Dark blue bars show the estimated proportion of HIV+ adults who knew their status (first 90 target) and the estimated proportion of those who knew their HIV+ status who were on ART (second 90 target), pre-intervention. Red bars show the same estimated proportions, post-intervention. ART, antiretroviral therapy.</p

Estimated proportions of HIV+ individuals who knew their status and who were on ART before the CHiP visit, immediately after the CHiP visit, and at the end of Round 1, in those consenting to the intervention.

<p>Estimated proportions of HIV+ individuals who knew their status and who were on ART before the CHiP visit, immediately after the CHiP visit, and at the end of Round 1, in those consenting to the intervention.</p

Overview of design of the HPTN 071 (PopART) trial.

<p>ART, antiretroviral therapy; TB, tuberculosis.</p

First two 90 target estimates by sex and age group in those consenting to the PopART intervention and extrapolated to the total adult population.

<p>The red line shows the 90% target for first two of the 90-90-90 targets. The first 90 target is proportion of individuals with knowledge of HIV-positive status, and the second 90 target is proportion of known HIV-positive individuals on antiretroviral therapy. CHiP, community HIV-care provider.</p

Estimated coverage compared with the first two 90 targets in those consenting to the PopART intervention.

<p>Dark blue bars show the estimated proportion of HIV+ adults who knew their status (first 90 target) and the estimated proportion of those who knew their HIV+ status who were on ART (second 90 target), pre-intervention. Red bars show the same estimated proportions, post-intervention. ART, antiretroviral therapy.</p

Overall estimates of proportion of HIV+ adults on ART by age group and sex in those consenting to the PopART intervention and extrapolated to the total adult population.

<p>The red line shows the cumulative 81% target based on first two of the 90-90-90 targets. ART, antiretroviral therapy; CHiP, community HIV-care provider.</p

Cascade of care from enumeration of household members through ART initiation during the first annual round of the PopART intervention.

<p>ART, antiretroviral therapy.</p

Estimated proportions of HIV+ individuals who knew their status and who were on ART before the CHiP visit, immediately after the CHiP visit, and at the end of Round 1, in total adult population.

<p>Estimated proportions of HIV+ individuals who knew their status and who were on ART before the CHiP visit, immediately after the CHiP visit, and at the end of Round 1, in total adult population.</p

Projected impact of the intervention on HIV incidence in Arms A and B compared with Arm C for central and optimistic target scenarios (specific parameter values for each scenario defined in Table S10 in File S1).

<p>Projected impact of the intervention on HIV incidence in Arms A and B compared with Arm C for central and optimistic target scenarios (specific parameter values for each scenario defined in Table S10 in File S1).</p

Uncertainty on the trial outcome in Zambia (top panels) and South Africa (bottom panels).

<p>The red and blue histograms show the relative reduction in 3-year cumulative incidence in arms A and B respectively when parameters vary within ranges shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084511#pone-0084511-t001" target="_blank">Table 1</a>. The left panels show results obtained when all parameters are varied, and the right panels when assuming no population-level behavioural changes associated with the intervention.</p