Blazar Flaring Patterns (B-FlaP): Classifying Blazar Candidates of Uncertain type in the third Fermi-LAT catalog by Artificial Neural Networks

The Fermi Large Area Telescope (LAT) is currently the most important facility for investigating the GeV $\gamma$-ray sky. With Fermi LAT more than three thousand $\gamma$-ray sources have been discovered so far. 1144 ($\sim40\%$) of the sources are active galaxies of the blazar class, and 573 ($\sim20\%$) are listed as Blazar Candidate of Uncertain type (BCU), or sources without a conclusive classification. We use the Empirical Cumulative Distribution Functions (ECDF) and the Artificial Neural Networks (ANN) for a fast method of screening and classification for BCUs based on data collected at $\gamma$-ray energies only, when rigorous multiwavelength analysis is not available. Based on our method, we classify 342 BCUs as BL Lacs and 154 as FSRQs, while 77 objects remain uncertain. Moreover, radio analysis and direct observations in ground-based optical observatories are used as counterparts to the statistical classifications to validate the method. This approach is of interest because of the increasing number of unclassified sources in Fermi catalogs and because blazars and in particular their subclass High Synchrotron Peak (HSP) objects are the main targets of atmospheric Cherenkov telescopes.Comment: 18 pages, 17 figures, accepted for publication on MNRA

Chamber basis of the Orlik-Solomon algebra and Aomoto complex

We introduce a basis of the Orlik-Solomon algebra labeled by chambers, so called chamber basis. We consider structure constants of the Orlik-Solomon algebra with respect to the chamber basis and prove that these structure constants recover D. Cohen's minimal complex from the Aomoto complex.Comment: 16 page

The Hilbert space operator formalism within dynamical reduction models

Unlike standard quantum mechanics, dynamical reduction models assign no particular a priori status to `measurement processes', `apparata', and `observables', nor self-adjoint operators and positive operator valued measures enter the postulates defining these models. In this paper, we show why and how the Hilbert-space operator formalism, which standard quantum mechanics postulates, can be derived from the fundamental evolution equation of dynamical reduction models. Far from having any special ontological meaning, we show that within the dynamical reduction context the operator formalism is just a compact and convenient way to express the statistical properties of the outcomes of experiments.Comment: 25 pages, RevTeX. Changes made and two figures adde

Sub-lethal 5-fluorouracil dose challenges planarian stem cells promoting transcriptional profile changes in the pluripotent sigma-class neoblasts

Under physiological conditions, the complex planarian neoblast system is a composite of hierarchically organized stem cell sub-populations with sigma-class neoblasts, including clonogenic neoblasts, endowed with larger self-renewal and differentiation capabilities, thus generating all the other sub-populations and dominating the regenerative process. This complex system responds to differentiated tissue demands, ensuring a continuous cell turnover in a way to replace aged specialized cells and maintain tissue functionality. Potency of the neoblast system can be appreciated under challenging conditions in which these stem cells are massively depleted and the few remaining repopulate the entire body, ensuring animal resilience. These challenging conditions offer the possibility to deepen the relationships among different neoblast sub-populations, allowing to expose uncanonical properties that are negligible under physiological conditions. In this paper, we employ short, sub-lethal 5-fluorouracil treatment to specifically affect proliferating cells passing through the S phase and demonstrate that S-phase slowdown triggers a shift in the transcriptional profile of sigma neoblasts, which reduces the expression of their hallmark sox-P1. Later, some cells reactivate sox-P1 expression, suggesting that some neoblasts in the earlier steps of commitment could modulate their expression profile, reacquiring a wider differentiative potential

Thesaurus: un database per il patrimonio culturale sommerso

Thesaurus Project aims at promoting the knowledge of the underwater cultural heritage, ancient and modern, through the application of several typologies of tools: underwater autonomous vehicles, which will be able to explore the sea bottom in teams communicating with each other; a database, which will be useful to store and manage all the information referring to archaeological or historical objects, shipwrecks and sites. This paper aims to explain the logic structure of the database indicating the particular needs of the research, the different typologies of items which have to be managed (archaeological and historical objects; ancient, medieval or modern shipwrecks; underwater sites; written or figurative sources, etc.), the relation with other similar databases and projects. The main task of this part of Thesaurus is to plan and organize an IT system, which will allow archaeologists to describe information in detail, in order to make an efficient managing and retrieving data system available

Discovery of periodic dips in the brightest hard X-ray source of M31 with EXTraS

We performed a search for eclipsing and dipping sources in the archive of the EXTraS project - a systematic characterization of the temporal behaviour of XMM-Newton point sources. We discovered dips in the X-ray light curve of 3XMM J004232.1+411314, which has been recently associated with the hard X-ray source dominating the emission of M31. A systematic analysis of XMM-Newton observations revealed 13 dips in 40 observations (total exposure time $\sim$0.8 Ms). Among them, four observations show two dips, separated by $\sim$4.01 hr. Dip depths and durations are variable. The dips occur only during low-luminosity states (L$_{0.2-12}<1\times10^{38}$ erg s$^{-1}$), while the source reaches L$_{0.2-12}\sim2.8\times10^{38}$ erg s$^{-1}$. We propose this system to be a new dipping Low-Mass X-ray Binary in M31 seen at high inclination (60$^{\circ}$-80$^{\circ}$), the observed dipping periodicity is the orbital period of the system. A blue HST source within the Chandra error circle is the most likely optical counterpart of the accretion disk. The high luminosity of the system makes it the most luminous dipper known to date.Comment: 11 pages, 2 figures, 5 tables, accepted for publication in ApJ

Relative influence of the adeno-associated virus (AAV) type 2 p5 element for recombinant AAV vector site-specific integration.

The p5 promoter region of the adeno-associated virus type 2 (AAV-2) rep gene has been described as essential for Rep-mediated site-specific integration (RMSSI) of plasmid sequences in human chromosome 19. We report here that insertion of a full-length or minimal p5 element between the viral inverted terminal repeats does not significantly increase RMSSI of a recombinant AAV (rAAV) vector after infection of growth-arrested or proliferating human cells. This result suggests that the p5 element may not improve RMSSI of rAAV vectors in vivo