Additional file 1: of The impact of nasal aspiration with an automatic device on upper and lower respiratory symptoms in wheezing children: a pilot case-control study

Figure S1. The DuoBaby nebulizer (a) and its functional scheme (b). Figure S2. Salbutamol consumption (expressed in percentage of days) among patients younger (cases n = 16, controls n = 16) or older (cases n = 27, controls n = 30) than 24 months and using a DuoBaby nebulizer equipped (cases) or not equipped (controls) with a nasal aspirator. Percentages are calculated considering the total days with symptoms over the total day of reported days (see method for definition). Chi-squared test was used to evaluate frequency differences between independent groups. Figure S3. Percentage of days with symptoms among patients using a DuoBaby nebulizer equipped (cases, n = 43) or not equipped (controls; n = 46) with an nasal aspirator. Percentage are calculated reporting the total days with symptoms on the total number of reported days. Chi-squared test was used to evaluate the association of categorical data between independent groups. Significant differences are highlighted as follows: *p < 0.05,** < 0.01, *** < 0.001. †Statistical significant differences after adjusting for multiple repeated measures through mixed-effects logistic regression. Table S1. List of the questions in the BreathMonitor APP (electronic Diary). Table S2. Questionnaire on the DuoBaby’s nebulizer unit. Table S3. Questionnaire on the use of the DuoBaby’s nasal aspirator. Table S4. Frequency of symptoms among patients using a DuoBaby nebulizer equipped (cases, n = 43) or not equipped (controls; n = 46) with a nasal aspirator stratified by age in months.* (DOCX 579 kb