Regression analysis between T1D incidence rate and Co, Cr, Cu, Mn, Pb, Zn.

<p>On the X axis the geochemical elements value (ppm) is reported; on the Y axis is reported T1D incidence rate normalized by Homogeneous Areas (HA). For each element the correlation coefficient, R, and the respective P value are shown.</p

Correlation coefficients between geochemical elements.

<p>Correlation coefficients between geochemical elements.</p

(A and B): Spatial distribution of T1D incidence rate and Co, Cr, Cu, Mn, Pb, Zn values in Sardinia.

<p>The results relate to 109 Homogeneous Areas (HA) identified from the lithological point of view. T1D incidence rate is represented by a chromatic scale, dividing values into three ranges, as indicated in the legend. Circles size symbolizes the amount of metal (ppm) detected in stream sediments samples, according to three ranges listed in the legend.</p

Correlation coefficients between geochemical elements and T1D incidence rates,

<p>n.s.: not statistically significant</p><p>Correlation coefficients between geochemical elements and T1D incidence rates,</p

Multivariable GLMMs results.

<p>Multivariable GLMMs results.</p

Scree plots of the principal component analysis (with and without copper).

<p>Scree plots of the principal component analysis (with and without copper).</p

The 25 municipalities forming the study area, the sampling sites and the ore bodies.

<p>The 25 municipalities forming the study area, the sampling sites and the ore bodies.</p

Results of principal component analysis (PCA).

<p>Results of principal component analysis (PCA).</p