Characteristic of subjects showing occult HCV.

*<p>: −/− indicates normal values below 50 IU/L and 35 IU/L for men and women respectively for ALT, and below 40 IU/L and 32 IU/L for men and women respectively for AST determination.</p><p>n.d.: the amplification resulting in a very weak fragment and sequence analysis did not succeed.</p

Baseline characteristics of the subcohort according to presence or absence of metabolic syndrome.

<p>Baseline characteristics of the subcohort according to presence or absence of metabolic syndrome.</p

Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome and number of metabolic syndrome components.

<p>¹Stratified by age (5-year classes) and centre.</p><p>²Adjusted for menopausal status (whole cohort model only), number of full-term pregnancies, age at menarche, smoking status, education, physical activity, and alcohol intake; stratified by age (5-year classes) and centre.</p><p>³P for interaction between metabolic syndrome and menopausal status.</p><p>Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome and number of metabolic syndrome components.</p

Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome components.

<p>¹Stratified by age (5-year classes) and centre.</p><p>²Adjusted for menopausal status (whole cohort model only), number of full-term pregnancies, age at menarche, smoking status, education, physical activity, and alcohol intake; stratified by age (5-year classes) and centre.</p><p>³P for interaction between metabolic syndrome components and menopausal status.</p><p>Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome components.</p

Major cardiovascular events (Panel A) and major cerebrovascular events (Panel B): crude and adjusted Cox models.

<p>Model 1 is adjusted by smoking status, alcohol consumption, physical activity, Italian Mediterranean Index, energy intake, and body mass index. Model 2 is adjusted by baseline hypertension, baseline hypercholesterolemia, and prevalent diabetes. Model 3 is adjusted as in Model 1+ Model 2. All models are adjusted by age and sex and stratified by center.</p

HRs for developing colorectal, colon and rectal cancer by increasing tertiles of dietary TAC.

<p>¹ mmol Trolox equivalents/day.</p><p>² Adjusted for age and sex; stratified for center.</p><p>³ Additionally adjusted for BMI, height, smoking status, education and total physical activity; stratified for center.</p><p>⁴ Additionally adjusted for intakes of alcohol, non-alcohol energy intake, red meat, processed meat, calcium and dietary fiber; stratified for center.</p><p>⁵P trends were calculated from the Cox model treating each category as a continuous variable.</p><p>HRs for developing colorectal, colon and rectal cancer by increasing tertiles of dietary TAC.</p

Direct Acyclic Graph (DAG) for the association of low educational status and Major Cardiovascular Events with results from Structural Equation Model.

<p>Direct Acyclic Graph (DAG) for the association of low educational status and Major Cardiovascular Events with results from Structural Equation Model.</p

Univariate analysis: baseline exposures by RII tertiles.

<p>P-values from chi square or 1-way analysis of variance, as appropriate.</p

Logistic regression models for the association between the relative index of inequality (RII) and clinical risk factors: hypertension at baseline (Panel A), hypercholesterolemia at baseline (Panel B), and diabetes at baseline (Panel C).

<p>Multivariate models are adjusted by age, sex, center, smoking status, physical activity, alcohol consumption, Dietary Mediterranean index, and energy intake.</p

Univariate analysis: baseline exposures in the disease-free cohort and in participants with cardiovascular events (CE) and cerebrovascular events (CBVD).

<p>P-values from chi square or t-test as appropriate.</p