Synthesis, characterization and Antioxidant evaluation of Cu (II), Zinc (II) and Cd (II) complexes derived from 2-((2-(piperazine-1-yl)ethylimino)methyl)phenol

The Schiff base ligand 2-((2-(piperazine-1-yl)ethylimino)methyl)phenol (L-OH) and its complexes of Cu (II), Zinc (II) and Cadmium (II) were synthesized and characterized by FTIR, 1HNMR, UV-visible, elemental analysis, TGA and LC-MS. The structure of [C13H18CdCl2N3O] was confirmed by x-ray diffraction. The data obtained from the characterization shows that both complexes have composition of ML type. The thermal analysis results revealed high thermal stability for all the complexes and that the anions and the ligands are decomposed at first, and then followed by the decomposition of the whole complex at the subsequent steps. The resulting compounds were evaluated for antioxidant activity.Keywords: Antioxidant, Characterization, Synthesis, X-ray

Synthesis, Characterization and Antibacterial Evaluations of the Schiff Base 2-(1-(2-(Piperazin-1-yl)ethylimino)ethyl)Phenol and its Complexes of Mn(II), Ni(II) and Zn(II)

Schiff base 2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and its complexes of Mn(II), Ni(II) and Zn(II) were synthesized and characterized by molar conductance, FTIR, NMR, UV-Visible and elemental analysis. The complexes showed 1:1 metal to ligand (M:L) ratio according to the result obtained from Job’s method analysis. Elemental analysis and IR spectral data are in good agreement with the proposed structure of the ligand and the complexes. Both the ligand and its complexes were screened for in-vitro antibacterial activity against two gram negative (Escherichia coli and Klebsella) and two gram positive (Staphylococcus aureus and Streptococcus pyrogenes) bacterial strains. The result of antibacterial activity showed that both the ligand and its complexes have activity more than the referenced drug and that the complexes are more active than free ligand.Keywords: Antibacterial studies, Characterization, Continuous variation, Synthesi

Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin