2,179 research outputs found
Medical Devices Competitiveness and Impact on Public Health Expenditure
This study provides an analytical overview of the state of the European Union medical device industry. The medical device industry sector encompasses an extremely large variety of products and technologies. It covers hundreds of thousands of products that range from more traditional products, such as bandages or syringes, to sophisticated devices that incorporate bioinformatics, nanotechnology and engineered cells. These are designed for use by practitioners, patients and healthy individuals in a variety of settings: hospitals, surgeries and private homes. Besides being a vital and innovative industry, medical devices are a key component of healthcare systems and represent, together with pharmaceuticals, the bulk of ‘medical technology’. The analysis of the sector must therefore investigate medical devices as an industry – an innovative contributor to the economy – as well its key input to healthcare systems. The following aspects are taken into account: a) the impact of innovation in medical devices on health costs and expenditure; b) the innovativeness of the European medical device industry; c) the competitiveness of the European medical device industry as compared to that of the United States and Japan.healthcare expenditure; medical devices; competitiveness; innovation
Management of severe epistaxis during pregnancy: a case report and review of the literature
Epistaxis is a common problem during pregnancy. Few cases of severe epistaxis, not associated with nasal lesions or clotting disorders, were described in the literature. We reported a case of severe epistaxis in a pregnant patient, exploring all the different possible management options
WEIGHT-BASED STIGMATIZATION, DISTRESS PSICOLOGICO ED UTILIZZO DEI SERVIZI SANITARI IN SOGGETTI OBESI: UN APPROCCIO MIXED-METHOD
Comparison between soluble ST2 and high-sensitivity troponin I in predicting short-term mortality for patients presenting to the Emergency Department with chest pain
Background: High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. Methods: Assays for hs-cTnI and sST2 were performed in 157 patients admitted to the Emergency Department (ED) for chest pain at arrival. In-hospital and 30-day follow-up mortalities were assessed. Results: The incidence of ACS was 37%; 33 patients were diagnosed with ST elevation myocardial infarction (STEMI), and 25 were diagnosed with non-ST elevation myocardial infarction (NSTEMI). Compared with the no acute coronary syndrome (NO ACS) group, the median level of hs-cTnI was higher in ACS patients: 7.22 (5.24-14) pg/mL vs 68 (15.33-163.50) pg/mL (P35 ng/mL at ED arrival died during the 30-day follow-up. Conclusions: sST2 has a greater prognostic value for 30-day cardiac mortality after discharge in patients presenting to the ED for chest pain compared with hs-cTnI. In STEMI patients, an sST2 value > 35 ng/mL at ED arrival showed the highest predictive power for short-term mortality
Serum Cystatin C for the diagnosis of acute Kidney Injury in Patients Admitted in the Emergency Department
BACKGROUND: Early diagnosis of acute kidney injury (AKI) at emergency department (ED) is a challenging issue. Current diagnostic criteria for AKI poorly recognize early renal dysfunction and may cause delayed diagnosis. We evaluated the use of serum cystatin C (CysC) for the early and accurate diagnosis of AKI in patients hospitalized from the ED.
METHODS: In a total of 198 patients (105 males and 93 females), serum CysC, serum creatinine (sCr), and estimated glomerular filtration rate (eGFR) were calculated at 0, 6, 12, 24, 48, and 72 hours after presentation to the ED. We compared two groups according to the presence or absence of AKI.
RESULTS: Serial assessment of CysC, sCr, and eGFR was not a strong, reliable tool to distinguish AKI from non-AKI. CysC > 1.44 mg/L at admission, both alone (Odds Ratio = 5.04; 95%CI 2.20-11.52; P < 0.0002) and in combination with sCr and eGFR (Odds Ratio = 5.71; 95%CI 1.86-17.55; P < 0.002), was a strong predictor for the risk of AKI.
CONCLUSIONS: Serial assessment of CysC is not superior to sCr and eGFR in distinguishing AKI from non-AKI. Admission CysC, both alone and in combination with sCr and eGFR, could be considered a powerful tool for the prediction of AKI in ED patients
Factors affecting hesitancy to mrna and viral vector COVID-19 vaccines among college students in Italy
Vaccine hesitancy (VH) may be significant in jeopardizing efforts to mass containment of COVID-19. A cross-sectional survey was carried out on a sample of 2667 Italian college students, before the COVID-19 vaccines became available for this age group (from 7 May to 31 May 2021). An online survey was created to obtain information about socio-demographic, health-related, and psychological factors linked to mRNA and viral vector COVID-19 vaccines. Statistically significant higher VH (30.4%) and vaccine resistance (12.2%) rates were found for viral vector than mRNA COVID-19 vaccines (7.2% and 1.0%, respectively; p < 0.001). Factors related to viral vector VH were partially different from those related to mRNA VH. Students with greater endorsement on conspiracy statements and negative attitudes toward the vaccine had higher odds of being vaccine-hesitant or-resistant. Students who had received a previous COVID-19 test and who scored higher on the agreeableness personality dimension had lower odds to be vaccine-hesitant or-resistant. The willingness to choose the vaccine was related to the viral vector but not to the mRNA VH. Taking into consideration the factors involved in vaccine hesitancy/resistance in college students could represent a key public health strategy to increase vaccine coverage and reduce viral spreading
Fatigue behaviour of a GFRP laminate by thermographic measurements
Composite materials are widely used to build structural components, thanks to their mechanical properties. Those are generally considered ‘engineering materials’, since they are tailored to meet specific requirements. Due to their use for structural components, it is important to know their mechanical behaviour, especially under cyclic loads. At present, there is a common interest, among researchers, to study the mechanical behaviour of composites, by means of both traditional and innovative techniques, with the final purpose of making previsions regarding their service life. In fact, due to their composite nature, they behave in a different mode compared to homogeneous materials. This study is focused on a glass fibre-reinforced plastic (GFRP); the aim of this work is to study its fatigue behaviour, from both the mechanical and the thermal points of view. The main reason is that there is a lack of knowledge, in the literature, about the fatigue of composites. In this study, a GFR laminate was characterized under static and dynamic loading conditions; during the experimental tests, thermal measurements were carried out by means of an IR-thermal camera. Temperature measurements were done during the static tests, whereas in the dynamic tests the dissipated energy was measured, by using the dissipation method (D-mode). Then, various criteria for fatigue life estimation were applied fitting the experimental data. Since different thermographic techniques have been used to estimate the fatigue behaviour, a final comparison between the experimental data and the predicted fatigue behaviour is proposed and discussed, showing a good agreement
Sucrose metabolism: Anabaena sucrose-phosphate synthase and sucrose-phosphate phosphatase define minimal functional domains shuffled during evolution
Based on the functional characterization of sucrose biosynthesis related proteins [SBP: sucrose-phosphate synthase (SPS), sucrose-phosphate phosphatase (SPP), and sucrose synthase (SuS)] in Anabaena sp. PCC7120 and sequence analysis, we have shown that SBP are restricted to cyanobacterium species and plants, and that they are multidomain proteins with modular architecture. Anabaena SPS, a minimal catalytic SPS unit, defines a glucosyltransferase domain present in all SPSs and SuSs. Similarly, Anabaena SPP defines a phosphohydrolase domain characteristic of all SPPs and some SPSs. Phylogenetic analysis points towards the evolution of modern cyanobacterial and plant SBP from a bidomainal common ancestral SPS-like gene.Fil: Cumino, Andrea Carina. Fundación para Investigaciones Biológicas Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Curatti, Leonardo. Fundación para Investigaciones Biológicas Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Giarrocco, Laura Estela. Fundación para Investigaciones Biológicas Aplicadas; ArgentinaFil: Salerno, Graciela Lidia. Fundación para Investigaciones Biológicas Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Supramolecular organization of new chiral π-conjugated oligomers: synthesis and spectroscopic study
π-Conjugated polymers and oligomers are widely used as organic semiconductors in devices such as
field-effect transistors (OFET), light-emitting diodes (OLED) and solar cells (OPV)1; in the last years, a very
important role in this field has been played by olygothiophenes2. Their optoelectronic properties (structure of
the absorption bands, fluorescence efficiency, charge and exciton transport) depend not only on the chemical
nature and the conformation assumed, but also on their supramolecular organization in the solid state. In particular,
the introduction of chiral groups can be used to drive their self-assembly.
We shall summarize our recent results about the supramolecular aggregation of three new chiral π- conjugated
oligomers, consisting of an aromatic central ring (1,4-hydroquinone, benzo[1,2-b:4,5-b′]dithiophene-
4,8-diol, 1,4-diketopyrrolo[3,4-c]pyrrole) functionalized with two (S)-3,7-dimethyl-1-octyl groups and connected
to two 2,2'-bithienyl units. In particular, we shall discuss: a) the synthetic route developed for the preparation of these new molecules;b) the characterization of their supramolecular aggregates in solution and of their thin films through
optical (UV-VIS, fluorescence) and chiroptical (electronic circular dichroism) spectroscopies, in connection
with optical microscopy investigation
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