Analgesics: New Target and Sources

The aim of this chapter is to describe targets for analgesic drugs, including currently available target sites and possible future target sites for pain and information regarding analgesia for complete understanding of pain originating mechanism, pathways and related theories to recognize. This chapter fully describes methods for determination of analgesic effects of synthetic and natural substances by inducing pain in different models and methods of pain induction

CORPORATE MEDIA MANIPULATION IN THE US WARS: A CASE STUDY OF IRAQ WAR

Media, as a source of information, plays a crucial role in opinion-making and perception-building. During the Iraq War (2003), the media's role was to shape the images of war while propagating specific ideas to influence the people. As a result, the world perceived propagandistic messages that appeared to take the form of fake news. The disinformation campaign was designed to profess the threat of weapons of mass destruction and explicate Saddam Hussein's affiliation with terrorist organizations as a threat to the world. The instantly shared live images, videos, recordings, and pictures across mass media platforms elicited shock, dismay, and disbelief throughout the world. With this insight, this paper attempts to comprehend the role of media propaganda which promoted the agenda of a media spectacle of the US military victory by transforming into a presentation of anarchy that destabilizes the rationale behind the invasion. It also provides an overview of the development of the Iraq War through the lens of the Herman-Chomsky Propaganda model. This model elucidates the role of propaganda in manipulating the opinion of the Iraqi people and how it was used to achieve economic, social, and political advantages.   Bibliography Entry Javed, Huma, and Arshi Saleem Hashmi. 2021. “Corporate Media Manipulation in the US Wars: A Case Study of Iraq War.” Magalla Papers 25 (1): 143-152

CD34+ hematopoietic progenitor cells enumeration and mononuclear cell count: an experience from a tertiary care centre

Background: This study was conducted to assess the CD34+ hematopoietic progenitor cells enumeration by flow cytometry and the utility of performing mononuclear cell count before performing the Stem cell enumeration. Collection was done on two consecutive days with CD34+ hematopoietic progenitor cell enumeration of both the samples. Mononuclear cell counts were done in all the patients. The purpose of the study was to do counts directly from the leukapheresis pack and see the reliability of this practice.Methods: Samples were collected from the leukapheresis pack and subjected to mononuclear cell count and CD34+ hematopoietic progenitor cells enumeration by flow cytometty before harvesting.Results: A total of 66 samples from 34 patients were taken up for the study. 76.47% of our cases were that of multiple myeloma and 17.64% of the cases were that of non Hodgkin lymphoma and 2.94% cases each of neuroblastoma and Hodgkin lymphoma. It was noted that the mononuclear cell counts correlated well with the CD34+ HPC in most of the cases with MNC being above 4 x 108 per pack per kg body weight in cases where CD34+ HPC counts were more than the desired lower limit of 2 x 106 per pack per kg body weight.Conclusions: It was observed that flow cytometric enumeration of CD34+ hematopoietic progenitor cells directly from the leukapheresis pack gave satisfactory results even without doing peripheral blood CD34+ HPCs enumeration before leukapheresis. Also, in our study we were able to set a limit of mononuclear Cell at 4 x 108 per pack/kg BW as counts beyond that always correlated with the more accurate flow cytometric method of CD34+ HPC count of more than 2 x106 per pack/kg body weight, therefore acting as a crude method for assessing the mobilization

Comparison of need and supply of syringes for therapeutic injections in Pakistan

Objectives: To determine the extent of shortfall in syringes by measuring the need from nationally validated sources and comparing it with position on the supply side. This was done in order to contribute to the ongoing national discussions that have focused on increasing syringe supply to curtail syringe reuse.Methods: Using \u27Injections received\u27 data from the Pakistan Demographic Health Survey 2006-7 (N: 5429) and the National Hepatitis Survey (N: 47,043), the study estimated the number of injections received in Pakistan. We matched these against the local syringe production figures from the syringe manufacturers\u27 association and import figures from the Federal Board of Revenue (FBR).Results: Approximately 731+/-867 million injections (5.1 12 injections per head) are received annually in Pakistan and around 861+/-961 million syringes are supplied to the open market. Overall, 52-77% Pakistanis receive at least one injection in any given year.Conclusions: Injection need in Pakistan is among the highest worldwide but is completely matched by available syringe supplies, suggesting lower reuse than previously considered. However, highly prevalent Hepatitis B and C viruses suggest that even this reuse is a major public health concern and measures directed at both providers and recipients of injections are needed to curtail high injection need and syringe reuse

Predictors of Outcome of Bronchiolitis in Children Using Children Hospital of Wisconsin Respiratory Score: An Experience of a Tertiary Care Hospital

Objective: To study the correlation of CHWR score and its various clinical markers with the length of stay in hospital bronchiolitis. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Pediatrics Combined Military Hospital, Lahore Pakistan, from Nov 2018 to Apr 2019. Methodology: This study included children aged 2 to 24 months, clinically diagnosed with bronchiolitis. The Receiver Operator Characteristic (ROC) was used to determine the discriminative validity of the CHWR score in predicting the length of stay. Results: One hundred thirty-eight children of either gender were enrolled in the study. The median age of the study population was 10.8 (9) months. ROC curve showed significant discriminate validity of CHWR score and its component criterion on admission. CHWR score of >10.5 predicted a longer stay (>24 hours) in ICU. Pearson correlation showed a statistically significant positive correlation between CHWR score at admission and length of stay (r=0.831, p=<0.001). Conclusion: CHWR scoring system on admission is an easy, safe and effective way to classify bronchiolitis severity and thus help predict the length of stay

GENITOFEMORAL NERVE BLOCK AND INTRAOPERATIVE ANALGESIA IN CHILDREN DURING INGUINAL HERNIA REPAIR

ABSTRACT Ilioinguinal and iliohypogastric nerve blocks has been widely used in children undergoing inguinal herniorraphy. This technique may provide insufficient intraoperative analgesia as the inguinal region may receive innervation from genitofemoral nerve. We proposed that the addition of genitofemoral nerve block might improve the quality of analgesia. The objective was to find the efficacy of genitofemoral nerve block in addition to ilioinguinal and iliohypogastric nerve block for better intraoperative pain management in children under going inguinal hernia repair under general anaesthesia. After informed consent, 100 children of 1-10 yrs of age and ASA I or II status undergoing inguinal hernia repair were selected and divided in group I and II of 50 patients each. After induction of general anaesthesia, Group I patients received ilioinguinal and iliohypogastric block using bupivacaine 0.375% at a dose of 0.75 mg/kg, where as patients in group II were given genitofemoral in addition to ilioinguinal and iliohypogastric nerve blocks using bupivacaine 0.375% at a dose of 0.375 mg/kg at each site. Changes in heart rate, systolic, diastolic and mean arterial pressures were recorded before the start of surgery, at skin incision, at sac traction and at the end of surgery as a measure of efficacy of the block. Haemodynamic data was analysed using repeated measures ANOVA. The two groups showed increase in (Heart Rate) but the increase was lesser in group II at sac traction (p&lt;0.05). In group I all patients had an increase in systolic, diastolic and mean arterial pressure at sac traction while the patients in group II showed no change during the study period (p&lt;0.05). We conclude that the addition of a genitofemoral nerve block to ilioinguinal and iliohypogastric nerve blocks may contribute to haemodynamic stability during sac traction indicating better pain relief

Awareness, use and perceptions about E-cigarettes among adult smokers in Karachi, Pakistan.

OBJECTIVE: To estimate the prevalence of awareness, current use and intention to use of e-cigarettes among adult smokers. METHODS: This cross-sectional survey was carried out at the Aga Khan University Hospital, Karachi, from July to August 2016, and comprised people aged above 18 years who had smoked more than 100 cigarettes in their lifetime. Convenience sampling method was used. A self-administered questionnaire was used to collect data. SPSS 22 was used for data analysis.. RESULTS: Of the 387 participants, 359(92.8%) were male. The overall mean age was 32.4±12.6 years. Moreover, 215(55.5%) respondents belonged to the middle socio-economic class. Besides, 249(64.3%) respondents were aware of e-cigarettes while 39(10.1%) used them, and 81(20.9%) wanted to use them. Socio-economic status was the best predictor for awareness about e-cigarettes (p CONCLUSIONS: The percentage of e-cigarette usage was low despite the higher than expected awareness among the subjects

Antecedents of computer self-efficacy and behavioral intention to use new IT : an investigation of the role of personality traits

Computer self-efficacy has been shown to play an important role in one's decision to use new information technology. While there has been a wealth of research on the antecedents of CSE, only a few have examined CSE's relationship with individual characteristics and it is only recently that the role of stable individual traits has gained prevalence. Meanwhile, in the 1990's, researchers converged upon the Five-Factor Model of personality as the premiere framework of personality and uncovered several relationships between these 5 factors of personality (neuroticism, extraversion, openness, conscientiousness, and agreeableness) and organizational behavior variables. Due to a needed focus on individual differences as they relate to IT use, in conjunction with the emergence of the five-factor model of personality as a credible tool in psychology, the present study aims at investigating the relationships between the five factors of personality and computer self-efficacy. A web-survey of 143 faculty members and graduate students who had not yet used the Self-Checkout library system available at a large Canadian university was conducted. Results suggest that extraversion is positively related to CSE, while neuroticism is negatively related to CSE. Results also indicate a positive relationship between CSE and perceived ease of use, and a positive relationship between PEOU and behavioral intention to use new IT. The study offers a humanistic viewpoint to the technology adoption literature, adds to research examining the relationship between stable and dynamic individual differences, and to organizational behavior literature that has shown a renewed interest in the role of personality in organizational contexts. Results are also useful in training and selection processes

Patient with ataxia telangiectasia undergoing elective staging laparoscopy: a case report and literature review

Ataxia telangiectasia is a rare autosomal recessive condition which develops due to a mutation in the ataxia telangiectasia mutated gene (ATM gene). As a result of this mutation, the ability of the DNA to undergo repair is undermined. The resulting cellular demise is responsible for the diverse presentation of the clinical condition. Neurological symptoms such as cerebellar ataxia, abnormal eye movements and malignancies occur commonly. Immunodeficiency predisposes these patients to recurrent infections. Perioperative management of patients with this rare condition can be associated with increased morbidity. Therefore, it is recommended that patients with ataxia telangiectasia should be managed in a multidisciplinary center, under the supervision of senior clinicians who have the insight into the clinical needs of such patients. We report herein, the perioperative management of a patient with Ataxia telangiectasia undergoing laparoscopic procedure. Continuous...