A case of pulmonary capillary haemangiomatosis (PCH) diagnosed by lung biopsy

WOS: 00020937040213

Relationship of Systemic Antiinflammatory Markers and Functional Parameters in Chronic Obstructive Pulmonary Disease

Objective: Airway inflammation and oxidative stress biomarkers increase in chronic obstructive pulmonary disease (COPD) and this is thought to be related to faster decrease in lung functions. Systemic markers of oxidative stress include nitric oxide (NO) and malonyl dialdehyde (MDA), while antioxidant markers are erythrocyte superoxide dismutase (SOD) and gluthathion-peroxidase (GSH-Px). We investigated the relationship between levels of systemic oxidative/antioxidant markers and functional parameters

Relationship between BODE index, quality of life and inflammatory cytokines in COPD patients.

Background and aims: Recently a multidimensional grading system based on the body mass index (B), degree of airflow obstruction (O), dyspnea (D) and exercise capacity (E) - the BODE index - has begun to be used increasingly for the evaluation of chronic obstructive pulmonary disease (COPD) patients. The aim of our study was to investigate the relationship between the BODE index and disease duration, annual exacerbation and hospitalization rates, health related quality of life and systemic inflammatory markers like C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha and interleukin (IL)-8

Factors affecting treatment success in community-acquired pneumonia

WOS: 000389053000029PubMed ID: 27966314Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 +/- 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 +/- 6237.3 vs. 8495.6 +/- 7279.5/mm(3)), higher blood urea levels (66.1 +/- 42.1 vs. 51.2 +/- 38.2 mg/dL), higher Pneumonia Severity Index (PSI) scores (123.3 +/- 42.6 vs. 96.3 +/- 32.9), higher CURB-65 scores (2.7 +/- 1.2 vs. 2.2 +/- 0.9), lower PaO2/FiO(2) ratios (216.3 +/- 86.8 vs. 269.9 +/- 65.6), and the presence of multilobar (33.3% vs. 16.4%) and bilateral (41.7% vs. 18.9%) radiologic infiltrates were related to treatment failure. The PSI score and PaO2/FiO(2) ratio were independent param-eters affecting treatment results in multivariate linear regression analysis (P < 0.001). Conclusion: The risk of treatment failure is high in patients with severe pneumonia and with respiratory failure. Effective treatment and close monitoring are required for these cases

Factors Affecting the Interval from Diagnosis to Treatment in Patients with Lung Cancer

Aims and background. We aimed to investigate the factors affecting the interval from the beginning of the symptoms until diagnosis and treatment in patients with lung cancer

Factors affecting the interval from diagnosis to treatment in patients with lung cancer

Aims and background. We aimed to investigate the factors affecting the interval from the beginning of the symptoms until diagnosis and treatment in patients with lung cancer

Mannose binding lectin (MBL) gene polymorphism and relationship between serum MBL concentrations in COPD patients

Aim: We aimed to assess mannose-binding lectin (MBL) gene polymorphisms and serum MBL concentrations in a sample of Turkish chronic obstructive pulmonary disease (COPD) patients as well as in cigarette smokers. Furthermore, we looked for the possible correlations of serum MBL concentrations with pulmonary function tests

Effects of vaccination on clinical presentation of community acquired pneumonia (CAP)

WOS: 00020937040217

Serum procalcitonin and C-reactive protein kinetics as indicators of treatment outcome in hospitalized patients with community-acquired pneumonia

WOS: 000389053000023PubMed ID: 27966308Background/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients (57 males, mean age: 61.5 +/- 16.7 years) were enrolled in the study. Treatment failure (TF) was observed in 20 patients (19.4%). Pneumonia Severity Index scores, serum CRP levels, and PCT levels on admission were significantly higher in the TF group. There were significant decreases in CRP and PCT levels between admission day and day 3 in the treatment success group. Conclusion: In patients with CAP, the body temperature and leukocyte count on admission do not predict outcome. Monitoring levels of CRP and PCT may be useful as a predictor of treatment outcome

Factors affecting treatment success in community acquired pneumonia (CAP)

WOS: 00020937040245