Genetic diversity of Mycobacterium leprae isolates from Brazilian leprosy patients

Submitted by Sandra Infurna ([email protected]) on 2018-09-25T17:17:57Z No. of bitstreams: 1 amanda_fontes_etal_IOC_2009.pdf: 376703 bytes, checksum: ec0c4b7b9b14df59fc4f776733a26280 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2018-09-25T17:24:17Z (GMT) No. of bitstreams: 1 amanda_fontes_etal_IOC_2009.pdf: 376703 bytes, checksum: ec0c4b7b9b14df59fc4f776733a26280 (MD5)Made available in DSpace on 2018-09-25T17:24:17Z (GMT). No. of bitstreams: 1 amanda_fontes_etal_IOC_2009.pdf: 376703 bytes, checksum: ec0c4b7b9b14df59fc4f776733a26280 (MD5) Previous issue date: 2009Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.Colorado State University. Department of Microbiology, Immunology and Pathology. Fort Collins, Colorado, USA.Instituto Lauro de Souza Lima, Bauru. SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Colorado State University. Department of Microbiology, Immunology and Pathology. Fort Collins, Colorado, USA.Colorado State University. Department of Microbiology, Immunology and Pathology. Fort Collins, Colorado, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada a Micobactérias. Rio de Janeiro, RJ. Brasil.Introduction Leprosy is a chronic disease caused by infection with Mycobacterium leprae, an obligate intracellular parasite. A problem in studying the transmission of leprosy is the small amount of variation in bacterial genomic DNA. The discovery of variable number of tandem repeats (VNTRs) allowed the detection of strain variation in areas with a high prevalence of leprosy. Four genotypes of M. leprae based on three single-nucleotide polymorphism (SNPs) were also discovered to be useful for analysis of the global spread of leprosy