9 research outputs found
Overexpression of orphan receptor GPR61 increases cAMP levels upon forskolin stimulation in HEK293 cells:in vitro and in silico validation of 5-(nonyloxy)tryptamine as a low-affinity inverse agonist
No full textGeissospermiculatine, a new alkaloid from Geissospermum reticulatum bark
Get PDFA new alkaloid, geissospermiculatine was characterized in Geissospermum reticulatum A. H. Gentry bark (Apocynaceae). Here, following a simplified isolation protocol, the structure of the alkaloid was elucidated through GC-MS, LC-MS/MS, 1D, and 2D NMR (COSY, ROESY, HSQC, HMBC, 1H-15N HMBC). Cytotoxic properties were evaluated in vitro on malignant THP-1 cells, and the results demonstrated that the cytotoxicity of the alkaloid (30  μg/mL) was comparable with staurosporine (10  μM). Additionally, the toxicity was tested on zebrafish (Danio rerio) embryos in vivo by monitoring their development (0-72 h); toxicity was not evident at 30  μg/mL
Aggressive Perpetration and Victimization Among Polish Male and Female Adolescents: The Role of Attachment to Parents and Self-Control
No full textThe Level of Personality Organization and Revictimization in Lives of Child Sexual Abuse Survivors
No full textPoly-Victimization in Polish Adolescents: Risk Factors and the Moderating Role of Coping
No full text
