Additional file 1: Table S1. of Multi-complexity measures of heart rate variability and the effect of vasopressor titration: a prospective cohort study of patients with septic shock

Online Data Supplement. Evaluated complexity measures and association with success of vasopressor titration on univariate and multivariate analyses. (DOCX 30 kb

MOESM1 of Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients

Additional file 1: Table S1. Patients stratified according to presence of shock (presence of vasopressor at time of echo) or no shock

Hospital characteristics.

<p>Hospital characteristics.</p

Multivariate Model Adjusting for demographics and severity of illness.

<p>Multivariate Model Adjusting for demographics and severity of illness.</p

Patient Characteristics at Presentation.

<p>Patient Characteristics at Presentation.</p

Final multiple logistic regression model summaries.

<p>Final multiple logistic regression model summaries.</p

30-day mortality vs. white blood cell count.

<p>Stepwise plot of 30-day mortality rate against white blood cell count for the sample of 10,979 cardiac surgery patients, illustrating a positive relationship between the two variables.</p

Wound complications vs. white blood cell count.

<p>Stepwise plot of wound complications rate against white blood cell count for the sample of 10,979 cardiac surgery patients, illustrating a positive relationship between the two variables.</p

Preoperative asymptomatic leukocytosis and postoperative outcome in cardiac surgery patients

<div><p>Background</p><p>Despite showing a prognostic value in general surgical patients, preoperative asymptomatic elevated white blood cell (WBC) count is not considered a risk factor for cardiac surgery. Whereas there is sporadic evidence of its value as a preoperative risk marker, it has not been looked at methodically as a specific index of outcome during cardiac surgery. Using a national database we sought to determine the relationship between preoperative WBC count and postoperative outcome in cardiac surgical patients.</p><p>Methods</p><p>Cardiac surgeries were extracted from the 2007–2013 American College of Surgeons National Surgical Quality Improvement Program database. Leukocytosis was defined by a preoperative WBC count greater than 11,000 cells/μL. A univariate analysis compared the incidence of adverse outcomes for patients with and without leukocytosis. A multivariate logistic regression model was constructed in order to test whether leukocytosis was an independent predictor of morbidity and mortality.</p><p>Results</p><p>Out of a total of 10,979 cardiac surgery patients 863 (7.8%) had preoperative leukocytosis. On univariate analysis, patients with leukocytosis experienced greater incidences of 30-day mortality, wound complications, and medical complications. Wound complications included surgical site infection as well as wound dehiscence. The medical complications included all other non-surgical causes of increased morbidity and infection leading to urinary tract infection, pneumonia, ventilator dependence, sepsis and septic shock. After stepwise model adjustment, leukocytosis was a strong predictor of medical complications (OR 1.22, 95% CI: 1.09–1.36, p = 0.002) with c-statistic of 0.667. However, after stepwise model adjustment leukocytosis was not a significant predictor of 30-day mortality and wound complications.</p><p>Conclusion</p><p>Preoperative leukocytosis is associated with adverse postoperative outcome after cardiac surgery and is an independent predictor of infection-related postoperative complications.</p></div

Medical complications vs. white blood cell count.

<p>Stepwise plot of medical complications rate against white blood cell count for the sample of 10,979 cardiac surgery patients, illustrating a positive relationship between the two variables.</p