Foregrounds for redshifted 21 cm studies of reionization: GMRT 153 MHz observations

Foreground subtraction is the biggest challenge for future redshifted 21 cm observations to probe reionization. We use a short GMRT observation at 153 MHz to characterize the statistical properties of the background radiation across ~ one degree to sub-arcminutes angular scales, and across a frequency band of 5 MHz with 62.5 kHz resolution. The statistic we use is the visibility correlation function, or equivalently the angular power spectrum C_l. We present the results obtained from using relatively unsophisticated, conventional data calibration procedures. We find that even fairly simple minded calibration allows one to estimate the visibility correlation function at a given frequency V_2(U,0). From our observations we find that V_2(U,0) is consistent with foreground model predictions at all angular scales except the largest ones probed by our observations where the the model predictions are somewhat in excess. On the other hand the visibility correlation between different frequencies kappa(U, Delta nu), seems to be much more sensitive to calibration errors. We find a rapid decline in kappa(U, Delta nu), in contrast with the prediction of less than 1 % variation across 2.5 MHz. In this case however, it seems likely that a substantial part of the discrepancy may be due to limitations of data reduction procedures.Comment: 10 pages, 7 figures, 1 table, Accepted for Publication in MNRA

Genetic Variants of APOL1 Are Major Determinants of Kidney Failure in People of African Ancestry With HIV

INTRODUCTION: Variants of the APOL1 gene are associated with chronic kidney disease (CKD) in people of African ancestry, although evidence for their impact in people with HIV are sparse. METHODS: We conducted a cross-sectional study investigating the association between APOL1 renal risk alleles and kidney disease in people of African ancestry with HIV in the UK. The primary outcome was end-stage kidney disease (ESKD; estimated glomerular filtration rate [eGFR] of 30 mg/mmol), and biopsy-proven HIV-associated nephropathy (HIVAN). Multivariable logistic regression was used to estimate the associations between APOL1 high-risk genotypes (G1/G1, G1/G2, G2/G2) and kidney disease outcomes. RESULTS: A total of 2864 participants (mean age 48.1 [SD 10.3], 57.3% female) were genotyped, of whom, 354 (12.4%) had APOL1 high-risk genotypes, and 99 (3.5%) had ESKD. After adjusting for demographic, HIV, and renal risk factors, individuals with APOL1 high-risk genotypes were at increased odds of ESKD (odds ratio [OR] 10.58, 95% CI 6.22–17.99), renal impairment (OR 5.50, 95% CI 3.81–7.95), albuminuria (OR 3.34, 95% CI 2.00–5.56), and HIVAN (OR 30.16, 95% CI 12.48–72.88). An estimated 49% of ESKD was attributable to APOL1 high-risk genotypes. CONCLUSION: APOL1 high-risk genotypes were strongly associated with kidney disease in people of African ancestry with HIV and accounted for approximately half of ESKD cases in this cohort

Sickle Cell Trait and Kidney Disease in People of African Ancestry With HIV

Introduction: Sickle cell trait (SCT) has been associated with chronic kidney disease (CKD) in African Americans, although evidence for its impact in Africans and people with HIV is currently lacking. We conducted a cross-sectional study investigating the association between SCT and kidney disease in people of African ancestry with HIV in the UK. Methods: The primary outcome was estimated glomerular filtration rate (eGFR) 50 mg/mmol), and albuminuria (albumin-to-creatinine ratio >3 mg/mmol). Multivariable logistic regression was used to estimate the associations between SCT and kidney disease outcomes. Results: A total of 2895 participants (mean age 48.1 [SD 10.3], 57.2% female) were included, of whom 335 (11.6%) had SCT and 352 (12.2%) had eGFR <60 ml/min per 1.73 m2. After adjusting for demographic, HIV, and kidney risk factors including APOL1 high-risk genotype status, individuals with SCT were more likely to have eGFR <60 ml/min per 1.73 m2 (odds ratio 1.62 [95% CI 1.14–2.32]), eGFR <90 ml/min per 1.73 m2 (1.50 [1.14–1.97]), and albuminuria (1.50 [1.09–2.05]). Stratified by APOL1 status, significant associations between SCT and GFR <60 ml/min per 1.73 m2, eGFR <90 ml/min per 1.73 m2, proteinuria, and albuminuria were observed for those with APOL1 low-risk genotypes. Conclusion: Our results extend previously reported associations between SCT and kidney disease to people with HIV. In people of African ancestry with HIV, these associations were largely restricted to those with APOL1 low-risk genotypes

Solution and foaming properties of mixed aqueous solution of CTAB-Triton X-100

611-614The critical micelle concentrations (CMC) of mixed aqueous solution of cationic surfactant cetyltrimthylammonium bromide (CTAB) and nonionic surfactant polyoxyethylene t-octylphenol (Triton X-100/TX100) have been determined conductometrically at 35,40,45 and 50°C.The mixtures used are of various composition ratios of CTAB and TX100.The degree of ionization (∝)of the mixed micelle has been computed from the slope of conductance versus concentration (C) plot above and below CMC. Foaming efficiency and viscosity of mixed surfactants have been measured at 45°C.Wetting property of the above systems has also been studied. The concentration of TX100 is kept constant and that of CTAB changed