8 research outputs found
Acute Generalized Exanthematous Pustulosis as a Manifestation of Anticonvulsant Hypersensitivity Syndrome
Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine: First Case Report in Canada and Review of the Literature
Acute generalized exanthematous pustulosis caused by propafenone: An emerging skin adverse reaction
Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature
Allergic reactions to penicillins and cephalosporins: diagnosis, assessment of cross-reactivity and management
16 p.-3 fig.-4 tab.Introduction: Beta-lactams (BL) are the main cause of allergic drug reactions mediated by specific immunological mechanisms. Reactions can be IgE or effector T-cell mediated. The new antigenic
determinants are recognized by the immunological system in the context of the common betalactam structure or the specific differences in the side chains of the antibiotics of this family plus the
protein carrier.Areas covered: We have reviewed the recent clinical literature concerning new clinical entities, the
progress in diagnosis including the difficulties for in in vivo and or in vitro testing as well as the new
algorithms proposed for delabelling subjects classified as allergic to beta-lactams, and recommendations
for desensitization procedures.Expert opinion: The knowledge gained over the last years on beta-lactam hypersensitivity has enabled
a better understanding and management of cases with allergic reactions to beta-lactams.This work was supported by ISCIII Grants, the Network RIRAAF and ARADyAL [RD16/0006/0021, RD16/0006/0024 and RD16/0006/0032],SAF2015-68590-R and FEDER Funds.Peer reviewe