The Influence of Fandom Culture on the Formation of Primary School Students’ Values

The chief object of this study is to survey the influence of fandom culture on the formation of primary school students’ values and guidance strategies. Past studies have examined the impact of worshiping stars on the values of teenagers, but there are no specific research or guidance strategies on the effects of fandom culture on the value formation of primary students who are still in the early stages of value formation. The method used in our study is known as the literature analysis method, participatory observation method, questionnaire method, and Data analysis method. The research has recorded valuable data about the influence of fandom culture on the formation of primary school students’ values and has proved that the formation of values of primary school students is hardly influenced by fandom culture. This research finally put forward useful strategies to guide primary school students to form correct values from various perspectives

Impact of plateau pika burrowing activity on the grass/sedge ratio in alpine sedge meadows in China

DATA AVAILABILITY STATEMENT : The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.INTRODUCTION : Burrowing activities of plateau pikas cause widespread bare patches in alpine meadows on the Qinghai-Tibet Plateau, affecting the plant community composition and forage production. However, it is not clear how these bare patches influence the main forage composition in alpine meadows. METHODS : Therefore, we investigated the plant communities in bare patches (BP) and neighboring control plots (CK) in alpine meadows in Maqu county in the Gannan region of China. RESULTS : Our results showed that plant communities in the CK plots differed from those in the BP plots. The sedge cover, number of sedge species and number of grass species were all significantly higher in the CK plots compared to the BP plots. However, grass cover and its dry weight were significantly higher in the BP plots. Grass cover and the grass dry weight in the BP plots were 1.859 times and 1.802 times higher than that in the CK plots across the five sites, respectively. Grasses also had a significantly higher cover and dry weight than sedge in the BP plots, grass cover was 66.5 times higher than the sedge cover, and the grass dry weight was 68.242 times that of the sedge dry weight. Therefore, bare patches resulting from plateau pika burrowing activity significantly increase the grass/sedge ratio in alpine meadows. DISCUSSION : A potential explanation is that grasses have a stronger reproductive potential than sedges in bare soil. This has implications for pasture yields since grasses have a higher biomass per unit area compared to sedges in alpine meadows.Sichuan Natural Science Foundation of China, the Open Project Funding of the Key Laboratory of Southwest China Wildlife Resource Conservation (Ministry of Education) and the Research and Demonstration on Crucial Technologies of Wetland Eco-environment Protection Under the Influence of Highway Engineering on theWestern Sichuan Plateau.https://www.frontiersin.org/journals/plant-scienceam2023Zoology and Entomolog

Preservice Elementary Teacher Self-Efficacy and Attitude towards Teaching Science

The present study investigated the status and relationship between preservice elementary teacher self-efficacy and attitude towards teaching science. The researcher employed a mixed-method approach to collect both quantitative and qualitative data. The researcher used a questionnaire responded by 125 undergraduates who major in elementary education to collect quantitative data. The self-efficacy regarding teaching science includes five aspects, and the attitude towards teaching science consists of three aspects. Results show that preservice elementary teachers have both high self-efficacy regarding teaching science and positive attitudes towards teaching science. All the aspects of self-efficacy regarding teaching science are demonstrated to have a positive correlation with attitude towards teaching science and its corresponding aspects. A formula model was also constructed to predict the preservice elementary teachers’ attitude towards teaching science based on their self-efficacy regarding teaching science

Not only baseline but cumulative exposure of remnant cholesterol predicts the development of nonalcoholic fatty liver disease: a cohort study

Background and aim: Remnant cholesterol (remnant-C) mediates the progression of major adverse cardiovascular events. It is unclear whether remnant-C, and particularly cumulative exposure to remnant-C, is associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to explore whether remnant-C, not only baseline but cumulative exposure, can be used to independently evaluate the risk of NAFLD. Methods: This study included 1 cohort totaling 21,958 subjects without NAFLD at baseline who underwent at least 2 repeated health checkups and 1 sub-cohort totaling 2,649 subjects restricted to those individuals with at least 4 examinations and no history of NAFLD until Exam 3. Cumulative remnant-C was calculated as a timeweighted model for each examination multiplied by the time between the 2 examinations divided the whole duration. Cox regression models were performed to estimate the association between baseline and cumulative exposure to remnant-C and incident NAFLD. Results: After multivariable adjustment, compared with the quintile 1 of baseline remnant-C, individuals with higher quintiles demonstrated significantly higher risks for NAFLD (hazard ratio [HR] 1.48, 95%CI 1.31–1.67 for quintile 2; HR 2.07, 95%CI 1.85–2.33 for quintile 3; HR 2.55, 95%CI 2.27–2.88 for quintile 4). Similarly, high cumulative remnant-C quintiles were significantly associated with higher risks for NAFLD (HR 3.43, 95%CI 1.95–6.05 for quintile 2; HR 4.25, 95%CI 2.44–7.40 for quintile 3; HR 6.29, 95%CI 3.59–10.99 for quintile 4), compared with the quintile 1. Conclusion: Elevated levels of baseline and cumulative remnant-C were independently associated with incident NAFLD. Monitoring immediate levels and longitudinal trends of remnant-C may need to be emphasized in adults as part of NAFLD prevention strategy

Image_1_Molecular subtypes based on Wnt-signaling gene expression predict prognosis and tumor microenvironment in hepatocellular carcinoma.tif

Based on increasing research evidence, hepatocellular carcinoma (HCC) is heterogeneous, and genetic profiling has led to the identification of multiple subtypes of this disease. To advance our knowledge and the ability to use individualized medicine in the treatment of HCC, it is essential to perform a complete and methodical characterization of various molecular subtypes. The canonical Wnt/β-catenin pathway is an evolutionarily conserved complicated signaling mechanism that plays a role in carcinogenesis and progression of HCC. In this study, we acquired RNA sequencing, somatic mutation, and clinical data from 701 patients from The Cancer Genome Atlas and Gene Expression Omnibus databases and stratified patients into two subgroups: WNT-high and WNT-low. In general, the WNT-high subtype is associated with an immunosuppressive microenvironment, poor prognosis, cancer-related pathways, and a low response to immune checkpoint therapy. We also found that WNT3 is negatively linked to CD8+ T-cell infiltration using multiple immunofluorescence assays. Finally, we developed a WNT-related prognostic model to predict the survival time of patients with HCC. In summary, we developed a new classification scheme for HCC based on Wnt signaling signatures. This classification produced substantial clinical effects, both in terms of assessing patient prognosis and immunotherapy administered to patients with HCC.</p

Image_4_Molecular subtypes based on Wnt-signaling gene expression predict prognosis and tumor microenvironment in hepatocellular carcinoma.tif

Based on increasing research evidence, hepatocellular carcinoma (HCC) is heterogeneous, and genetic profiling has led to the identification of multiple subtypes of this disease. To advance our knowledge and the ability to use individualized medicine in the treatment of HCC, it is essential to perform a complete and methodical characterization of various molecular subtypes. The canonical Wnt/β-catenin pathway is an evolutionarily conserved complicated signaling mechanism that plays a role in carcinogenesis and progression of HCC. In this study, we acquired RNA sequencing, somatic mutation, and clinical data from 701 patients from The Cancer Genome Atlas and Gene Expression Omnibus databases and stratified patients into two subgroups: WNT-high and WNT-low. In general, the WNT-high subtype is associated with an immunosuppressive microenvironment, poor prognosis, cancer-related pathways, and a low response to immune checkpoint therapy. We also found that WNT3 is negatively linked to CD8+ T-cell infiltration using multiple immunofluorescence assays. Finally, we developed a WNT-related prognostic model to predict the survival time of patients with HCC. In summary, we developed a new classification scheme for HCC based on Wnt signaling signatures. This classification produced substantial clinical effects, both in terms of assessing patient prognosis and immunotherapy administered to patients with HCC.</p

Image_2_Molecular subtypes based on Wnt-signaling gene expression predict prognosis and tumor microenvironment in hepatocellular carcinoma.tif

Based on increasing research evidence, hepatocellular carcinoma (HCC) is heterogeneous, and genetic profiling has led to the identification of multiple subtypes of this disease. To advance our knowledge and the ability to use individualized medicine in the treatment of HCC, it is essential to perform a complete and methodical characterization of various molecular subtypes. The canonical Wnt/β-catenin pathway is an evolutionarily conserved complicated signaling mechanism that plays a role in carcinogenesis and progression of HCC. In this study, we acquired RNA sequencing, somatic mutation, and clinical data from 701 patients from The Cancer Genome Atlas and Gene Expression Omnibus databases and stratified patients into two subgroups: WNT-high and WNT-low. In general, the WNT-high subtype is associated with an immunosuppressive microenvironment, poor prognosis, cancer-related pathways, and a low response to immune checkpoint therapy. We also found that WNT3 is negatively linked to CD8+ T-cell infiltration using multiple immunofluorescence assays. Finally, we developed a WNT-related prognostic model to predict the survival time of patients with HCC. In summary, we developed a new classification scheme for HCC based on Wnt signaling signatures. This classification produced substantial clinical effects, both in terms of assessing patient prognosis and immunotherapy administered to patients with HCC.</p

Image_3_Molecular subtypes based on Wnt-signaling gene expression predict prognosis and tumor microenvironment in hepatocellular carcinoma.tif

Based on increasing research evidence, hepatocellular carcinoma (HCC) is heterogeneous, and genetic profiling has led to the identification of multiple subtypes of this disease. To advance our knowledge and the ability to use individualized medicine in the treatment of HCC, it is essential to perform a complete and methodical characterization of various molecular subtypes. The canonical Wnt/β-catenin pathway is an evolutionarily conserved complicated signaling mechanism that plays a role in carcinogenesis and progression of HCC. In this study, we acquired RNA sequencing, somatic mutation, and clinical data from 701 patients from The Cancer Genome Atlas and Gene Expression Omnibus databases and stratified patients into two subgroups: WNT-high and WNT-low. In general, the WNT-high subtype is associated with an immunosuppressive microenvironment, poor prognosis, cancer-related pathways, and a low response to immune checkpoint therapy. We also found that WNT3 is negatively linked to CD8+ T-cell infiltration using multiple immunofluorescence assays. Finally, we developed a WNT-related prognostic model to predict the survival time of patients with HCC. In summary, we developed a new classification scheme for HCC based on Wnt signaling signatures. This classification produced substantial clinical effects, both in terms of assessing patient prognosis and immunotherapy administered to patients with HCC.</p

JD and Oridonin inhibits the growth of EC109 monoclonal cells.

<p>A. Cells were grown in a 6-well plate at a concentration of 1000 cells/well. After the cells became adherent, JD or Oridonin (0.5 μM, 1 μM and 2 μM) was added to the media, and the plates were incubated for approximately 7 days. Control colonies reached a typical density of 50 cells/colony after the 7-day incubation. Colonies were stained with crystal violet and images were obtained. This figure is a representative result of 3 independent experiments. The clonogenicity assay was quantified using Image J software. Inhibition rate = (1- number of treatment/number of control)*100% B. The rate of inhibition induced by JD or Oridonin was expressed as the Mean ± SD. * p < 0.05 versus control; **p < 0.01 versus control.</p