An Effective Route to a C-Phosphorylated Pyridazinone via use of Ph2Li. Synthesis and Quantum-chemical Calculations

Reaction of Ph2PLi and Ph2PH with 4,5-dichloro-2-phenylpyridazin-3-one was studied. A bis-phosphorylated pyridazinone, 4,5-bis(diphenylphosphino)-2-phenylpyridazin-3-one was prepared. Quantum-chemical calculations were used to examine the electronic structure of the reagents and to evaluate the stability of probable reaction products

New Reaction of 3,4-Dichloro-5-hydroxy-2(5H)-furanone with Trimethylsilylphosphites

The new reaction path of the phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with trimethylsilylphosphite is found. It is established that the reaction involves two reaction centres to give 4- and 5-phosphorylation products

Phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with tributylphosphine

The reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone with 2 mol of tributylphosphine involves substitution of both chlorine atoms to form an unstable diphosphonium salt. The latter undergoes partial hydrolysis with cleavage of one of the P-C bonds, yielding finally a monophosphorylation product. A probable reaction pathway is considered in terms of quantum chemistry

Synthesis of the first C-phosphorylated pyrrol-2(5H)-one. Quantum chemical calculations of the pyrrol-2(5H)one structures

A new approach to the synthesis of the first C-phosphorylated pyrrol-2(5H)-one is developed. Direct reaction of 3,4-dichloropyrrol-2(5H)-one with P-nucleophiles fails to give the desired compounds. This fact was explained on the basis of quantum-chemical calculations of the pyrrol-2(5H)-one structures. © 1996 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Peculiarities of dehydrohalogenation of phosphonium salts under the action of BuLi. Synthesis and X-ray and quantum-chemical studies of a new stable ylide

The reaction of tributyl(5-hydroxy-3-oxo-2-phenylpyridazin-4-yl)phosphonium chloride with butyllithium involves dehydrohalogenation to form the corresponding ylide. The structure of the latter is studied by X-ray diffraction and discussed in terms of quantum chemistry

New Reaction of 3,4-Dichloro-5-hydroxy-2(5H)-furanone with Trimethylsilylphosphites

The new reaction path of the phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with trimethylsilylphosphite is found. It is established that the reaction involves two reaction centres to give 4- and 5-phosphorylation products

An Effective Route to a C-Phosphorylated Pyridazinone via use of Ph2Li. Synthesis and Quantum-chemical Calculations

Reaction of Ph2PLi and Ph2PH with 4,5-dichloro-2-phenylpyridazin-3-one was studied. A bis-phosphorylated pyridazinone, 4,5-bis(diphenylphosphino)-2-phenylpyridazin-3-one was prepared. Quantum-chemical calculations were used to examine the electronic structure of the reagents and to evaluate the stability of probable reaction products

Synthesis of the first C-phosphorylated pyrrol-2(5H)-one. Quantum chemical calculations of the pyrrol-2(5H)one structures

A new approach to the synthesis of the first C-phosphorylated pyrrol-2(5H)-one is developed. Direct reaction of 3,4-dichloropyrrol-2(5H)-one with P-nucleophiles fails to give the desired compounds. This fact was explained on the basis of quantum-chemical calculations of the pyrrol-2(5H)-one structures. © 1996 MAEe cyrillic signK Hayκa/Interperiodica Publishing

New Reaction of 3,4-Dichloro-5-hydroxy-2(5H)-furanone with Trimethylsilylphosphites

The new reaction path of the phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with trimethylsilylphosphite is found. It is established that the reaction involves two reaction centres to give 4- and 5-phosphorylation products

New Reaction of 3,4-Dichloro-5-hydroxy-2(5H)-furanone with Trimethylsilylphosphites

The new reaction path of the phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with trimethylsilylphosphite is found. It is established that the reaction involves two reaction centres to give 4- and 5-phosphorylation products