Rectification of Sabah Stilt House Using Shear Wall Subjected to Earthquake

A moderate earthquake with 6.0-magnitude hit Sabah in 2015 especially in Ranau, Sabah has been labelled as one of the most powerful earthquakes ever in Malaysia. Numerous buildings in Sabah have become defective with the severity level of damages as absolute (non-repairable) in the RC beam-column joints and soft-storey structures. Seismic design and construction requirements were not considered in most buildings in Sabah. Hence, this research is to investigate how to mitigate the effect of earthquake on the low-rise building using a more practical and economical method. A stilt house model is developed using ABAQUS software to determine the behaviour of the stilt, low-rise building subjected to earthquake by constructing shear wall at the short columns support. There are 4 models constructed namely, frame model without shear wall (W1), with shear wall of 100mm (W2), 300mm (W3) and 500mm (W4). The results of seismic response are evaluated and compared. Different length of shear wall affects the displacement and stress of the frame model. As shear wall length increases, the displacement, stress at columns and stress at walls decreases. Thus, adding a shear wall can be used to retrofit stilt houses and a credible way to mitigate damage due to earthquake load for new houses along hill slope

Rectification of Sabah Stilt House Using Shear Wall Subjected to Earthquake

A moderate earthquake with 6.0-magnitude hit Sabah in 2015 especially in Ranau, Sabah has been labelled as one of the most powerful earthquakes ever in Malaysia. Numerous buildings in Sabah have become defective with the severity level of damages as absolute (non-repairable) in the RC beam-column joints and soft-storey structures. Seismic design and construction requirements were not considered in most buildings in Sabah. Hence, this research is to investigate how to mitigate the effect of earthquake on the low-rise building using a more practical and economical method. A stilt house model is developed using ABAQUS software to determine the behaviour of the stilt, low-rise building subjected to earthquake by constructing shear wall at the short columns support. There are 4 models constructed namely, frame model without shear wall (W1), with shear wall of 100mm (W2), 300mm (W3) and 500mm (W4). The results of seismic response are evaluated and compared. Different length of shear wall affects the displacement and stress of the frame model. As shear wall length increases, the displacement, stress at columns and stress at walls decreases. Thus, adding a shear wall can be used to retrofit stilt houses and a credible way to mitigate damage due to earthquake load for new houses along hill slope

Rectification of Sabah stilt house using shear wall subjected to earthquake

A moderate earthquake with 6.0-magnitude hit Sabah in 2015 especially in Ranau, Sabah has been labelled as one of the most powerful earthquakes ever in Malaysia. Numerous buildings in Sabah have become defective with the severity level of damages as absolute (non-repairable) in the RC beam-column joints and softstorey structures. Seismic design and construction requirements were not considered in most buildings in Sabah. Hence, this research is to investigate how to mitigate the effect of earthquake on the low-rise building using a more practical and economical method. A stilt house model is developed using ABAQUS software to determine the behaviour of the stilt, low-rise building subjected to earthquake by constructing shear wall at the short columns support. There are 4 models constructed namely, frame model without shear wall (W1), with shear wall of 100mm (W2), 300mm (W3) and 500mm (W4). The results of seismic response are evaluated and compared. Different length of shear wall affects the displacement and stress of the frame model. As shear wall length increases, the displacement, stress at columns and stress at walls decreases. Thus, adding a shear wall can be used to retrofit stilt houses and a credible way to mitigate damage due to earthquake load for new houses along hill slopes

Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis

BACKGROUND: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). In recent years, it has been found that cells such as human amnion epithelial cells (hAECs) have the ability to modulate immune responses in vitro and in vivo and can differentiate into multiple cell lineages. Accordingly, we investigated the immunoregulatory effects of hAECs as a potential therapy in an MS-like disease, EAE (experimental autoimmune encephalomyelitis), in mice. METHODS: Using flow cytometry, the phenotypic profile of hAECs from different donors was assessed. The immunomodulatory properties of hAECs were examined in vitro using antigen-specific and one-way mixed lymphocyte proliferation assays. The therapeutic efficacy of hAECs was examined using a relapsing-remitting model of EAE in NOD/Lt mice. T cell responsiveness, cytokine secretion, T regulatory, and T helper cell phenotype were determined in the peripheral lymphoid organs and CNS of these animals. RESULTS: In vitro, hAECs suppressed both specific and non-specific T cell proliferation, decreased pro-inflammatory cytokine production, and inhibited the activation of stimulated T cells. Furthermore, T cells retained their naïve phenotype when co-cultured with hAECs. In vivo studies revealed that hAECs not only suppressed the development of EAE but also prevented disease relapse in these mice. T cell responses and production of the pro-inflammatory cytokine interleukin (IL)-17A were reduced in hAEC-treated mice, and this was coupled with a significant increase in the number of peripheral T regulatory cells and naïve CD4+ T cells. Furthermore, increased proportions of Th2 cells in the peripheral lymphoid organs and within the CNS were observed. CONCLUSION: The therapeutic effect of hAECs is in part mediated by inducing an anti-inflammatory response within the CNS, demonstrating that hAECs hold promise for the treatment of autoimmune diseases like MS

Size Segregation in a Fluid-like or Gel-like Suspension Settling under Gravity or in a Centrifuge

We investigate size segregation effects in a bidisperse concentrated suspension when slowly settling under gravity or when submitted to a centrifugal field. Experiments are carried out with PMMA spheres of two different mean diameters (190 and 25 μm) suspended in a hydrophobic index-matched fluid. Spatial repartitions of both small and large spheres and velocity fluctuations of particles are measured using fluorescently labeled PMMA spheres and a particle-image-velocimetry method. Large particles behave as hard spheres in purely hydrodynamic interactions, while small spheres interact through weakly attractive forces. For a small amount of small spheres among large ones, the suspension remains fluid during settling and the organization of the velocity field of particles into finite-sized structures also called "blobs" promotes size segregation. A larger proportion of weakly attractive small spheres in the bidisperse suspension causes a considerable slowdown of the settling process under gravity and the occurrence of a large-scale collective behavior together with a loss of size segregation. When centrifuging the gel-like bidisperse suspension, a shear-induced melting of the particle network induces a spectacular segregation of species. As a consequence, aging tests of soft yielding materials using centrifugation methods are not representative of the shelf-life stability of the products. A tentative model based on the competition between viscous stresses acting upon particles and adhesive stresses gives a correct estimate of the critical stationary acceleration for the destabilization of the particle network and the onset of size segregation in a gel-like suspension