Diagnostic accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins in pharyngeal swabs compared to RT-PCR as a reference test

Nanoparticle-based biosensors (NPBs) are point-of-care diagnostic platforms that can be used for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high accuracy. EBSCOhost Web, Embase, ProQuest, PubMed/MEDLINE, Scopus, Web of Science, and WHO Global Literature on Coronavirus Disease 2019 (COVID-19) were searched for relevant records published from 1 November 2019 to 30 April 2022. Records reporting original data on the accuracy of clinically applied nanoparticle-based biosensors at detecting SARS-CoV-2 RNA and surface proteins from pharyngeal swab specimens were considered. Findings were reported based on the PRISMA 2020 statement. The QUADAS-2 tool was used for assessment of quality and risk of bias among the included studies. A total of 50 relevant records were identified, of which 13 were included. The included studies explored the diagnostic performance of 13 clinically applied distinct nanoparticle-based biosensors in a total of 789 pharyngeal swabs collected from 376 COVID-19 patients and 413 otherwise healthy individuals. The mean sensitivity, specificity, and accuracy were 97.07%, 94.43%, and 96.91%, respectively, in comparison to RT-qPCR as the reference test. Considering their ease-of-operation, portability, low-cost manufacturing, NPBs could be considered suitable candidate diagnostic platforms for substituting RT-qPCR.</p

Additional file 3 of The burden of vision loss in the Middle East and North Africa region, 1990–2019

Additional File 3: Table S3. YLDs due to vision loss in 1990 and 2019 for both sexes and the percentage change in the age-standardised rates (ASRs) per 100,000 in the North Africa and the Middle East region. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool )

sj-jpg-3-jad-10.1177_10870547231187161 – Supplemental material for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019

Supplemental material, sj-jpg-3-jad-10.1177_10870547231187161 for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019 by Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Shahrokh Amiri and Ali-Asghar Kolahi in Journal of Attention Disorders</p

sj-docx-7-jad-10.1177_10870547231187161 – Supplemental material for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019

Supplemental material, sj-docx-7-jad-10.1177_10870547231187161 for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019 by Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Shahrokh Amiri and Ali-Asghar Kolahi in Journal of Attention Disorders</p

Additional file 5 of The burden of vision loss in the Middle East and North Africa region, 1990–2019

Additional File 5: Figure S2. The percentage change in the age-standardised YLD rate of vision loss in the Middle East and North Africa region from 1990 to 2019, by sex and country. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool

Additional file 4 of The burden of vision loss in the Middle East and North Africa region, 1990–2019

Additional File 4: Figure S1. The percentage change in the age-standardised point prevalence of vision loss in the Middle East and North Africa region from 1990 to 2019, by sex and country. (Generated from data available from http://ghdx.healthdata.org/gbd-results-tool

sj-jpg-2-jad-10.1177_10870547231187161 – Supplemental material for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019

Supplemental material, sj-jpg-2-jad-10.1177_10870547231187161 for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019 by Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Shahrokh Amiri and Ali-Asghar Kolahi in Journal of Attention Disorders</p

sj-docx-4-jad-10.1177_10870547231187161 – Supplemental material for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019

Supplemental material, sj-docx-4-jad-10.1177_10870547231187161 for The Burden of Attention-Deficit Hyperactivity Disorder (ADHD) in the Middle East and North Africa Region, 1990 to 2019 by Saeid Safiri, Seyed Ehsan Mousavi, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Shahrokh Amiri and Ali-Asghar Kolahi in Journal of Attention Disorders</p

Multivariate analysis of child and caregivers’ psychological factors.

Multivariate analysis of child and caregivers’ psychological factors.</p

Additional file 1 of The burden of vision loss in the Middle East and North Africa region, 1990–2019

Additional File 1: Table S1. Sequelae for vision loss and the associated disability weights from the Global Burden of Disease 2019 Study