3 research outputs found
The study of chromosomal abnormalities and heteromorphism in couples with 2 or 3 recurrent abortions in Shahid Beheshti Hospital of Hamedan
Background: Different studies show that chromosomal balance
translocation in the parents can cause recurrent spontaneous abortions.
Incidence of chromosomal translocation abnormalities in couples with
repeated abortions is from 0% to 31%. Objective: The purpose of this
research was studying the presence or absence of chromosomal
abnormalities and heteromorphism in couples with recurrent abortions
and also the role of this anomaly in the abortions. Materials and
Methods: This study is a cross sectional descriptive study which have
investigated 75 couples who had three abortions or more, and 65 couples
who had two abortions that referred by gynecologist to the lab of
Beheshti Hospital in Hamedan for cytogenetical investigation. Also 40
healthy individuals without history of abortion investigated as control
group.GTG bonding technique (staining banding with gymsa and trypsin)
is used in this study. Results: Frequency of chromosomal abnormalities
and heteromorphism among couples with three or more abortions were
reported respectively 5.3% and 9.3%. This frequency in couples with two
abortions was respectively 3.07%and 6.15%. The frequency of chromosomal
heteromorphism in control group was 7.5% and no chromosomal
abnormalities were observed in them. Conclusion: This study shows that
chromosomal abnormality can be one reason of recurrent spontaneous
abortions and more abortion increases the probability of this anomaly.
Also, existence of chromosomal heteromorphism in the general population
without clinical abortion symptoms shows that chromosomal
heteromorphism cannot be the reason of these spontaneous abortions