Independent sets of some graphs associated to commutative rings

Let $G=(V,E)$ be a simple graph. A set $S\subseteq V$ is independent set of $G$, if no two vertices of $S$ are adjacent. The independence number $\alpha(G)$ is the size of a maximum independent set in the graph. %An independent set with cardinality Let $R$ be a commutative ring with nonzero identity and $I$ an ideal of $R$. The zero-divisor graph of $R$, denoted by $\Gamma(R)$, is an undirected graph whose vertices are the nonzero zero-divisors of $R$ and two distinct vertices $x$ and $y$ are adjacent if and only if $xy = 0$. Also the ideal-based zero-divisor graph of $R$, denoted by $\Gamma_I(R)$, is the graph which vertices are the set {x\in R\backslash I | xy\in I \quad for some \quad y\in R\backslash I\} and two distinct vertices $x$ and $y$ are adjacent if and only if $xy \in I$. In this paper we study the independent sets and the independence number of $\Gamma(R)$ and $\Gamma_I(R)$.Comment: 27 pages. 22 figure

Business Intelligence Systems Adoption Model: An Empirical Investigation

Decision support and business intelligence systems have been increasingly adopted in organizations, while understanding the nature of affecting factors on such adoption decisions need receiving much academic interest. This article attempts to provide an in-depth analysis toward understanding the critical factors which affect the decision to adopt business intelligence (BI) in the context of banking and financial industry. In this regard, it examines a conceptual model that shows the impacts of different technological, organizational, and environmental factors in the decision to adopt BI by a firm. Structural equation modeling (SEM) was used for data analysis and test the relevant hypothesis. The results of this article which are derived from theoretical discussion of hypothesizes show that from nine hypothesized relationships—perceived tangible and intangible benefits, firm size, organizational readiness, strategy, industry competition and competitors absorptive capacity—affect BIS adoption in the surveyed cases

The impact model of business intelligence on decision support and organizational benefits

Purpose – Decision support (DS), as a traditional management concept, have had a remarkable role in competitiveness or survival of organizations and nowadays, business intelligence (BI), as a brand modern impression, has various contributions in supporting decision-making process. Although, a variety of benefits are expected to arise from BI functions, researches, and models that determining the effect of BI functions on the decisional and organizational benefits are rare. The purpose of this paper is to study the relationship between BI functions, DS benefits, and organizational benefits in context of decision environment. Design/methodology/approach – This research conducts a quantitative survey-based study to represent the relationship between BI capabilities, decision support benefits, and organizational benefits in context of decision environment. On this basis, the partial least squares (PLS) technique employs a sample of 228 firms from different industries located in Middle-East countries. Findings – The findings confirm the existence of meaningful relationship between BI functions, DS benefits, and organizational benefits by supporting 15 out of 16 main hypotheses. Essentially, this research provides an insightful understanding about which capabilities of BI have strongest impact on the outcome benefits. Originality/value – The results can provide effective and useful insights for investors and business owners to utilize more appropriate BI tools and functions to reach more idealistic organizational advantages. Also it enables managers to better understand the application of BI functions in the process of achieving the specified managerial support benefits. Keywords Decision support benefits, Organizational benefits, BI functions, Business intelligence (BI) benefits, Partial least squares (PLS) technique Paper type Research pape

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intraperitoneally at 2.5 and 5 mg/kg doses for 10 days, and a single dose of cisplatin (8 mg/kg) was injected on the 7th day. Tests of kidney function and tubular injury in renal tissues and urine together with oxidative stress and inflammation markers were examined.Results: Tangeretin ameliorated cisplatin-induced elevations in serum creatinine, BUN, and histopathologic changes. It also attenuated kidney oxidative stress elicited by cisplatin as demonstrated by reduced MDA and increased GSH, CAT, and SOD activities, elevated Nrf2 expression and protein levels of its downstream effectors, HO-1 and NQO-1. Tangeretin further alleviated inflammation evoked by cisplatin as indicated by reduced NF-κB p65 subunit phosphorylation with a simultaneous decrement in its downstream effectors IL-1β and TNF-α expression and protein levels. Moreover, it declined caspase-3 protein levels and TUNEL positive cells in the kidneys, the markers of apoptosis and DNA fragmentation, thus improving renal endurance. Additionally, tangeretin mitigated renal levels of KIM-1 and NGAL, as well as urinary cystatin C and β2-microglobulin concentrations, the markers of renal tubular injury.Conclusion: Collectively, these data signify the binary profit of tangeretin: enhancement of renal protective mechanisms against cisplatin and attenuation of renal tubular cell injuries induced by the agent

Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis

Objective(s): Empagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, possesses verified anti-inflammatory and anti-oxidative stress effects against diabetic nephropathy. The present investigation aims to examine empagliflozin effects on the renal levels of high mobility group box-1 (HMGB1), a potent inflammatory cytokine, and its respective receptor toll-like receptor-4 (TLR-4) in STZ-induced diabetic rats.Materials and Methods: Empagliflozin at 10 mg/kg per os (p.o.) was administered for 4 weeks, starting 8 weeks after the induction of diabetes. Renal function, kidney inflammation, oxidative stress, and apoptosis markers as well as renal HMGB1, receptor for advanced glycation end products (RAGE), and TLR-4 levels were assessed.Results: In addition to down-regulating NF-κB activity in renal cortices, empagliflozin reduced renal levels of HMGB1, RAGE, and TLR-4. It alleviated renal inflammation as indicated by diminished renal expressions of inflammatory cytokines and chemokines like tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) and also decreased urinary levels of interleukin-6 (IL-6) and alpha-1 acid glycoprotein (AGP). Moreover, empagliflozin ameliorated renal oxidative stress as demonstrated by decreased renal malondialdehyde (MDA) and elevated renal activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX). It also suppressed renal caspase-3, the marker of apoptosis; and furthermore, enhanced renal function noticed by the declined levels of serum urea and creatinine.Conclusion: These findings underline that empagliflozin is able to attenuate diabetes-related elevations in renal HMGB1 levels, an influential inflammatory cytokine released from the necrotic and activated cells, and its correspondent receptors, i.e., RAGE and TLR-4

Inhibition of MicroRNA miR-222 with LNA Inhibitor Can Reduce Cell Proliferation in B Chronic Lymphoblastic Leukemia

MicroRNAs (miRNAs) are small regulatory molecules that negatively regulate gene expression by base-pairing with their target mRNAs. miRNAs have contribute significantly to cancer biology and recent studies have demonstrated the oncogenic or tumor-suppressing role in cancer cells. In many tumors up-regulation miRNAs has been reported especially miR-222 has been shown to be up-regulated in B chronic lymphocytic leukemia (B-CLL). In this study we assessed the effected inhibition of miR-222 in cell viability of B-CLL. We performed inhibition of mir-222 in B-CLL cell line (183-E95) using locked nucleic acid (LNA) antagomir. At different time points after LNA-anti-mir-222 transfection, miR-222 quantitation and cell viability were assessed by qRT-real time polymerase chain reaction and MTT assays. The data were analyzed by independent t test and one way ANOVA. Down-regulation of miR-222 in B-CLL cell line (183-E95) with LNA antagomir decreased cell viability in B-CLL. Cell viability gradually decreased over time as the viability of LNA-anti-mir transfected cells was <47 % of untreated cells at 72 h post-transfection. The difference in cell viability between LNA-anti-miR and control groups was statistically significant (p < 0.042). Based on our findings, the inhibition of miR-222 speculate represent a potential novel therapeutic approach for treatment of B-CLL

Application of multi-agent decision-making methods in hydrological ecosystem services management

In this paper, a methodology is presented for managing hydrological ecosystem services by taking into account the hierarchy of stakeholders involved in the decision-making process. With this in mind, a water allocation model is first used for allocating water resources to demands. Then, several ecosystem services (ESs)-based criteria are defined to evaluate hydrological ESs of water resources management policies. A set of water and environmental resources management strategies (alternatives) are defined for decision-makers, and several drought management strategies are determined to decrease the area of key crops and water demands of agricultural nodes. To model a multi-agent multi-criteria decision-making problem for managing hydrological ESs, three main steps are considered as follows: • Different ES-based criteria (i.e., economic profit, NPP,11 Net Primary Productivity and ecological index) are defined, and their grade-based values are estimated. • Several strategies are defined for stakeholders at different levels. • A recursive evidential reasoning (ER) approach, which considers a hierarchical structure for decision-makers and a leader-follower game, is used to select the best strategy for each decision-maker.The applicability and efficiency of the methodology are illustrated by applying it to a real-world case study. The methodology is general and can be easily applied to other study areas

Assessing the Relationship between Emotional Intelligence and Conflict Management Strategies among the Staff of Economy and Finance Ministry

Abstract-“Conflict ” is not an avoidable phenomenon in organizations, so the management and staff must detect it and reduce its negative effects. If the appropriate strategies are not used to resolve the conflict among the staff, it will lead to a serious damage to the organization. The main purpose of the present paper is to assess the relation between emotional intelligence and management strategies among the staff of economy and finance ministry which has been performed as a case study in Iran. In order to analyze the data collected from 279 employees of the economy and finance ministry, SPSS software has been used; in this regard, the questionnaires of emotional intelligence and conflict management strategies have been applied. The results of correlation coefficients show that there is a significant relation between the emotional intelligence and conflict management strategies; also, the employees with high emotional intelligence apply solution-orientated strategy to encounter with conflicts