Synthesis and Crystal Structure of 1-(3-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)thiourea

The title thiourea was synthesized by reaction of 3,4,5-trimethoxybenzoyl isothiocyante with 3-fluoroaniline. The 3,4,5-trimethoxybenzoyl isothiocyante was produced in situ by reaction of 3,4,5-trimethoxybenzoyl chloride with ammonium thiocyanate in dry acetonitrile. The structure was confirmed by the spectroscopic, elemental analysis and single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/c with unit cell dimensions a = 13.0966(9), b = 16.6460(13), c = 7.8448(5), β = 106.721(5)°, V 1637.9(2) ų, Z = 4

Correlating Serum Beta hCG Levels with Transvaginal Sonographic Features of Ectopic Pregnancy

To correlate Beta Hcg Levels withtransvaginal sonographic features of ectopicpregnancyMethods: In this prospective study 204 patientswith confirmed diagnosis of ectopic pregnancy (EP),by both trasnvaginal sonography (TVS) andhistopathology were included . Results of TVS andserum βHCG levels were obtained. Other variableswere age, gestational age, size, site and volume ofEP, fetal cardiac activity and presence or absence ofpelvic ascites.Results: Sensitivity and specificity of TVS fordetection of EP was 98% and 87.5% respectively. Thevalues of median and range for the age, gestationalage, βHCG and volume of EP were 29 (17-43) years,5(4-6) weeks, 3248.5 (14-53048) IU/L, 8648.36 (268-80491) mm3 respectively. Most common site of EPwas adnexa (93.6%) and most common side was right(52%). Fetal cardiac activity was evident in 4.4%cases and pelvic ascites was present in 64.7% cases.There was no significant difference between twoβHCG groups (<2000, >2000) in terms of qualitativeand quantitative variables except the volume of EPwhich was significantly different among groups (pvalue <0.0001).Conclusion: Serum βHCG level alone cannotdiagnose or exclude EP confidently and it issignificantly correlated with the size of EP. Thecombination of serum βHCG and TVS providehighly accurate diagnostic information

A Study on Assessment Practices at Beacon house School System in Pakistan

Assessment is an integral component of learning and teaching. The main purpose of this study was to examine the current assessment practices of teachers and as well as examination system in the Beaconhouse school system. Six schools of Beacon house system of Lahore, Faisalabad and Islamabad cities and their male and female teachers were the population of the study. Fifty teachers were selected as a sample on convenient basis. Data were collected through developing a questionnaire to ask teachers report on their assessment practices. It contained 30 items, each at the 5 point Likert type scale ranging from ‘always’ to ‘never’. The means and standard deviations were calculated for each item to find out the assessment practices being used in Beacon house Schools. The findings of the study revealed that Beacon house school teachers are informed about their use of assessment practices to examine learners’ reading performance. The teachers always inform results to the students but keep confidential from the irrelevant- stakeholders. They do not interpret percentile bands to students and parents and they do not consider students’ participation behavior or attitude in the promotion of next class. Uzma Perveen is currently working as a Senior Research Officer in National Accreditation Council for Teacher Education Higher Education Commission, Islamabad, Pakistan Dr. Muhammad Saeed is working as Associate Professor and Chairman at the Department of Educational Research, Institute of Education and Research, University of the Punjab, Lahore, Pakistan. He has widely published research in the field of science curriculum, teacher education, and educational assessment

1-(4-Fluoro­phen­yl)thio­urea

In the title compound, C7H7FN2S, the aromatic ring plane and the thio­urea unit are twisted with a torsion angle C—C—N—C7 of 44.6 (2)°. In the crystal, N—H⋯S and N—H⋯F inter­molecular hydrogen bonds link the mol­ecules into infinite sheets that are stacked along the c axis

4-Fluoro-N-[3-(2-fluoro­phen­yl)-4-methyl-2,3-dihydro-2-thienyl­idene]benzamide

In the title compound, C17H12F2N2OS, the planar thia­zole ring (r.m.s. deviation = 0.012 Å) makes dihedral angles of 15.08 (9) and 81.81 (6)° with the 4-fluoro­phenyl and 2-fluoro­phenyl rings, respectively. The 2-fluoro­phenyl ring is disordered over two orientations with site-occupancy factors of 0.810 (3) and 0.190 (3). The structure contains inter­molecular C—H⋯O hydrogen bonds

1-(2-Fluoro­phen­yl)-3-(3,4,5-trimethoxy­benzo­yl)thio­urea

The two m-meth­oxy groups of the title compound, C17H17FN2O4S, are almost coplanar with the aromatic ring [CH3—O—C—C = 5.8 (1) and 5.9 (1)°], whereas the meth­oxy group in the para position is bent out of the ring plane [78.6 (1)°]. Mol­ecules are connected by inter­molecular N—H⋯S hydrogen bonds to form centrosymmetric dimers that are stacked along the a axis

Factors associated with mammographic breast density among women in Karachi Pakistan

Background: There are no studies done to evaluate the distribution of mammographic breast density and factors associated with it among Pakistani women.Methods: Participants included 477 women, who had received either diagnostic or screening mammography at two hospitals in Karachi Pakistan. Mammographic breast density was assessed using the Breast Imaging Reporting and Data System. In person interviews were conducted using a detailed questionnaire, to assess risk factors of interest, and venous blood was collected to measure serum vitamin D level at the end of the interview. To determine the association of potential factors with mammographic breast density, multivariable polytomous logistic regression was used.Results: High-density mammographic breast density (heterogeneously and dense categories) was high and found in 62.4% of women. There was a significant association of both heterogeneously dense and dense breasts with women of a younger age group \u3c 45 years (OR 2.68, 95% CI 1.60-4.49) and (OR 4.83, 95% CI 2.54-9.16) respectively. Women with heterogeneously dense and dense breasts versus fatty and fibroglandular breasts had a higher history of benign breast disease (OR 1.90, 95% CI 1.14-3.17) and (OR 3.61, 95% CI 1.90-6.86) respectively. There was an inverse relationship between breast density and body mass index. Women with dense breasts and heterogeneously dense breasts had lower body mass index (OR 0.94 95% CI 0.90-0.99) and (OR 0.81, 95% CI 0.76-0.87) respectively. There was no association of mammographic breast density with serum vitamin D levels, diet, and breast cancer.Conclusions: The findings of a positive association of higher mammographic density with younger age and benign breast disease and a negative association between body mass index and breast density are important findings that need to be considered in developing screening guidelines for the Pakistani population

catena-Poly[[diaqua­calcium]bis­[μ-2-(1,3-dioxoisoindolin-2-yl)acetato]-κ3 O,O′:O;κ3 O:O,O′]

In the title complex, [Ca(C10H6NO4)2(H2O)2]n, the CaII atom lies on a twofold rotation axis and adopts a dodeca­hedral geometry. The CaII atom is octa­coordinated by two O atoms from two water mol­ecules and six O atoms from four acetate ligands. Each acetate acts as a tridentate ligand bridging two CaII atoms, resulting in a chain running along the c axis. O—H⋯O and C—H⋯O hydrogen bonds connect the chains into a two-dimensional network parallel to [011]. π–π inter­actions between adjacent isoindoline-1,3-dione rings [centroid–centroid distance = 3.4096 (11) Å] further consolidate the structure. One of the carboxylate O atoms is disordered over two sites in a 0.879 (12):0.121 (12) ratio

The 1:1 adduct of caffeine and 2-(1,3-dioxoisoindolin-2-yl)acetic acid

In the crystal structure of the title adduct [systematic name: 2-(1,3-dioxoisoindolin-2-yl)acetic acid–1,3,7-trimethyl-1,2,3,6-tetra­hydro-7H-purine-2,6-dione (1/1)], C8H10N4O2·C10H7NO4, the components are linked by an O—H⋯N hydrogen-bond and no proton transfer occurs