Anti-Caspr 2 Antibody Encephalitis: A Case Report

Encephalitis is a term denoted to Inflammation in the brain which can be due to infection, autoimmunity, or can be a part of a paraneoplastic phenomenon with malignancy. Anti-CASPR 2 antibody encephalitis is a rare form of encephalitis that can be associated with malignancy, paraneoplastic phenomenon or can be an autoimmune disease. We present a case of a young boy who presented with new onset seizures and altered sensorium and was diagnosed with anti-CASPR 2 antibody encephalitis. Anti-CASPR 2 Antibody Encephalitis is a rare form of encephalitis which due to its great diverse presentation should be kept in the differential diagnosis of conditions like limbic encephalitis

Cyclic Alternating Pattern of Encephalopathy (Cape) In CNS Infection: A Case Report

Cyclic Alternating Pattern of Encephalopathy (CAPE) is rare EEG phenomenon first described in 1944 in a comatose patient. It is similar to sleep EEG pattern of cyclic alternating pattern (CAP) which is a periodic electroencephalogram activity of non-REM sleep. The cyclic alternating pattern (CAP) is defined by sequences of transient electrocortical events that are different from the tonic background and repeat at intervals of up to one minute. CAPE, however, is abnormal EEG pattern. In this pattern of EEG abnormality slow wave activity of 1-2Hz alternates with fast activity of 6-10 hertz. Here we present a case of patient with CNS infection on mechanical ventilation whose EEG showed the above-mentioned pattern

Terson Syndrome in A Patient with Unrepaired Tetralogy of Fallot

Tetralogy of Fallot is the most commonly seen cyanotic congenital heart disease. It includes four cardinal features: right ventricular outflow tract obstruction, misaligned ventricular septal defect, overriding aorta, and concentric right ventricular hypertrophy. Intracranial pathologies such as brain abscesses, cerebrovascular accidents, and intracranial haemorrhage all have been reported with Tetralogy of Fallot. Here we present a case who had subarachnoid haemorrhage with vitreous haemorrhage in Tetralogy of Fallot

Psychiatric Comorbidity in People with Epilepsy

Background and Objective: People with epilepsy often experience psychiatric comorbidity. This study aims to investigate the relationship among seizure regulation, psychiatric comorbidity, and antiepileptic drug use in a group of individuals with epilepsy in Pakistan. Methods: This is an observational study conducted at Pakistan Institute of Medical Sciences, over a period of six months (1st June – 31st Dec 2022). One-hundred-twenty people (sample size) with epilepsy above the age of 18 with confirmed diagnosis of epilepsy were included in the study who completed a questionnaire that assessed their seizure control, psychiatric comorbidity, and antiepileptic drug use. Data was analyzed using SPSS version 25 Results: The majority of participants (80.8%) reported effective seizure control , while 19.2% reported ineffective seizure control . Regarding psychiatric comorbidity, 84.2% of the participants reported some form of psychiatric comorbidity, with depression being the most commonly reported (31.7%). In terms of antiepileptic drug use, 69.2% of the participants reported being on monotherapy, 28.3% reported being on polytherapy, and 2.5% reported not being on any medication. Conclusion: People with epilepsy have a significant likelihood of experiencing psychiatric comorbidity which highlights the need for screening and therapy