A CLINICAL STUDY ON THE EFFECT OF VIRECANA KARMA WITH TRIVRUTADI MODAKA IN THE MANAGEMENT OF TAMAKA SVASA (BRONCHIAL ASTHMA)

Tamaka svasa is a Vatakaphaja vyadhi, originating from Pittasthana and manifested through Pranavaha Srotas. Vata get obstructed by Kapha dosha and travels into Pratiloma gati (opposite direction) and in turn causes Svasa (Dyspnoea). Its clinical features resembles with Bronchial asthma. Objectives: The study was carried out to assess the role of Virecana karma in the management of Tamaka svasa with Trivrutadi Modaka. Materials and methods: The clinical study was conducted at Dr.B.R.K.R.Govt. Ayurvedic Hospital and Research Centre, Erragadda, Hyderabad. 30 patients of either sex fulfilling the clinical criteria for diagnosis of Tamaka svasa (bronchial asthma) were selected in accordance with following inclusion & exclusion criteria. Murchita Tilataila was given for Snehapana and the Virecana yoga was Trivrutadi Modaka. The result was assessed at every 15 days. Subjective and objective parameters were analyzed before and after the treatment. Results: There was moderate relief in 23 Patients (76.66%), Marked relief in 4 Patients (13.33%) and 3 Patients (10.00%) showed mild relief, Complete remission was not found. Conclusion: Virecana karma (Purgative Therapy) has given maximum effect to pacify the almost entire range of signs and symptoms associated with the disease and by reducing its frequency, severity, emergency drug usage and there by providing quality life to the patients

ROLE OF LEKHANA VASTI WITH VARAADI KWATHA IN STHAULYA W. S. R TO OBESITY-A PILOT STUDY

Obesity is a multi-factorial disorder, which is often associated with many other diseases such as DM, HTN, CHD, OA, infertility etc., In Ayurveda Sthaulya has been described since very early days. Susrutha described Lekhana vasti which can be used in Sthaulya. In present study Lekhana vasti with Varaadi kwatha was used to evaluate its role in case of Sthaulya. Methodology: Obese Patients were selected from O.P.D & I.P.D of Dr.B.R.K.R.Govt. Ayurvedic College, Hyderabad, on the basis of wt, BMI, body circumferences etc., 2 cycles of Lekhana vasti were given to each selected patient in form of 9 days 1 Anuvasana in between 3 Lekhana vasti with gap of 10 days in between two cycles. Results: The assessment of overall effect of therapy was done based on change in relevant examinations before and after treatment, and results found were encouraging. Conclusion: However still now there is no effective medicine in modern medicine. So, mankind hopes to search the perfect remedy from Ayurveda by its holistic approach. In this present study Lekhana vasti with Varaadi kwatha was tried and significant results were found in case of Sthaulya

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC), with clinical and biological implications. Lineage-dependent stromal transcriptional components could therefore dominate over more subtle expression traits inherent to cancer cells. Since in patient-derived xenografts (PDXs) stromal cells of the human tumour are substituted by murine counterparts, here we deploy human-specific expression profiling of CRC PDXs to assess cancer-cell intrinsic transcriptional features. Through this approach, we identify five CRC intrinsic subtypes (CRIS) endowed with distinctive molecular, functional and phenotypic peculiarities: (i) CRIS-A: mucinous, glycolytic, enriched for microsatellite instability or KRAS mutations; (ii) CRIS-B: TGF-\u3b2 pathway activity, epithelial\u2013mesenchymal transition, poor prognosis; (iii) CRIS-C: elevated EGFR signalling, sensitivity to EGFR inhibitors; (iv) CRIS-D: WNT activation, IGF2 gene overexpression and amplification; and (v) CRIS-E: Paneth cell-like phenotype, TP53 mutations. CRIS subtypes successfully categorize independent sets of primary and metastatic CRCs, with limited overlap on existing transcriptional classes and unprecedented predictive and prognostic performances