A model-based approach towards accelerated process development: A case study on chromatography

Process development is typically associated with lengthy wet-lab experiments for the identification of good candidate setups and operating conditions. In this paper, we present the key features of a model-based approach for the identification and assessment of process design space (DSp), integrating the analysis of process performance and flexibility. The presented approach comprises three main steps: (1) model development & problem formulation, (2) DSp identification, and (3) DSp analysis. We demonstrate how such an approach can be used for the identification of acceptable operating spaces that enable the assessment of different operating points and quantification of process flexibility. The above steps are demonstrated on Protein A chromatographic purification of antibody-based therapeutics used in biopharmaceutical manufacturing.Comment: Pre-print paper under revie

Operability-economics trade-offs in adsorption-based CO2_2 capture process

Low-carbon dispatchable power underpins a sustainable energy system, providing load balancing complementing wide-scale deployment of intermittent renewable power. In this new context, fossil fuel-fired power plants must be coupled with a post-combustion carbon capture (PCC) process capable of highly transient operation. To tackle design and operational challenges simultaneously, we have developed a computational framework that integrates process design with techno-economic assessment. The backbone of this is a high-fidelity PCC mathematical model of a pressure-vacuum swing adsorption process. We demonstrate that the cost-optimal design has limited process flexibility, challenging reactiveness to disturbances, such as those in the flue gas feed conditions. The results illustrate that flexibility can be introduced by relaxing the CO$_2$ recovery constraint on the operation, albeit at the expense of the capture efficiency of the process. We discover that adsorption-based processes can accommodate for significant flexibility and improved performance with respect to the operational constraints on CO$_2$ recovery and purity. The results herein demonstrate a trade-off between process economics and process operability, which must be effectively rationalised to integrate CO$_2$ capture units in the design of low-carbon energy systems.Comment: Pre-print paper currently under review. 32 pages, 6 figures. The first two authors contributed equally to this wor

IoT Based Water Level Control System

Nowadays, almost all communication using the internet, but is not all, now object also can communicating each other, this concept is calls the Internet of Things (IoT). Things in IoT can be everything that we use every day. In this project, the thing is a water container, or in Indonesia, it called ”bak mandi. Why water container? Because, after we use water in the water container usually the level of the water container is reduced and we must fill it up for other people that use the water container. Generally, in the process of filling the water container, we forgot to close the valve or pump so water is overflowing and the water is wasted. That is why we propose to use the Internet of Things concept that can solve the problem. Our approach utilizes a controller of ESP8266 that can provide monitoring level of the water container. That controller will open and close the pump or valve automatically so that the water is not overflowing and wasted. We use an ultrasonic sensor to sense the level of the water. We utilize the Blynk IoT service incorporated with PHP web programming in providing water level monitoring and control. We have tested the system on a 64 cm water container. The system has an error of 2 cm in controlling the water level

IoT Based Water Level Control System

Nowadays, almost all communication using the internet, but is not all, now object also can communicating each other, this concept is calls the Internet of Things (IoT). Things in IoT can be everything that we use every day. In this project, the thing is a water container, or in Indonesia, it called ”bak mandi. Why water container? Because, after we use water in the water container usually the level of the water container is reduced and we must fill it up for other people that use the water container. Generally, in the process of filling the water container, we forgot to close the valve or pump so water is overflowing and the water is wasted. That is why we propose to use the Internet of Things concept that can solve the problem. Our approach utilizes a controller of ESP8266 that can provide monitoring level of the water container. That controller will open and close the pump or valve automatically so that the water is not overflowing and wasted. We use an ultrasonic sensor to sense the level of the water. We utilize the Blynk IoT service incorporated with PHP web programming in providing water level monitoring and control. We have tested the system on a 64 cm water container. The system has an error of 2 cm in controlling the water level

ILC Reference Design Report Volume 1 - Executive Summary

The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization.The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2s^-1. This report is the Executive Summary (Volume I) of the four volume Reference Design Report. It gives an overview of the physics at the ILC, the accelerator design and value estimate, the detector concepts, and the next steps towards project realization