4 research outputs found
Sound StressāInduced Long-Term Enhancement of Mechanical Hyperalgesia in Rats Is Maintained by Sympathoadrenal Catecholamines
Epinephrine Produces a Ī²-Adrenergic Receptor-Mediated Mechanical Hyperalgesia and In Vitro Sensitization of Rat Nociceptors
Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy
A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C Īµ Mutant Mice
AbstractThere is great interest in discovering new targets for pain therapy since current methods of analgesia are often only partially successful. Although protein kinase C (PKC) enhances nociceptor function, it is not known which PKC isozymes contribute. Here, we show that epinephrine-induced mechanical and thermal hyperalgesia and acetic acidāassociated hyperalgesia are markedly attenuated in PKCĪµ mutant mice, but baseline nociceptive thresholds are normal. Moreover, epinephrine-, carrageenan-, and nerve growth factorā (NGF-) induced hyperalgesia in normal rats, and epinephrine-induced enhancement of tetrodotoxin-resistant Na+ current (TTX-R INa) in cultured rat dorsal root ganglion (DRG) neurons, are inhibited by a PKCĪµ-selective inhibitor peptide. Our findings indicate that PKCĪµ regulates nociceptor function and suggest that PKCĪµ inhibitors could prove useful in the treatment of pain