Comparative survey of native species culture (Penaeus semisulcatus and Fenneropenaeus indicus) with non-native species (Litopenaeus vannamei) in Hele site of Bushehr province

The culture of three species green tiger prown (Penaeus semisulcatus) ,white leg shrimp (Litopenaeus vannamei) and Indian white shrimp (Fenneropenaeus indicus) were grown in 7 ponds (0.4 and 0.25 hectare) for 110 days at a stocking density of 25 shrimp/m2 on Hele Research Station. The average of temperature and salinity was 30 degrees centigrade and 46-48 ppt .At the end of the culture mean weights of L.vannamei 18.68±2.6 was higer than the P.semisucatus 7.77±1.49 and F.indicus 14.66 ±2.1 also results demonstrated that there was a significant relation (P<0.05) between mean weight. Final yield were 3114, 1983 and 848 Kg for L.vannamei, F.indicus and P.semisucatus.The FCR was better for L.vannamei (1.28) than F.indicus (1.48) and P.semisucatus (2.15)

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium

Abstract Despite increasing evidence suggesting that angiotensin II type 2 receptor (AT2R) may regulate tissue inflammation, no study has yet analyzed its possible implication in rheumatoid arthritis (RA) synovitis. In this study, we investigated the expression and function of AT2R in synovial tissue and cultured fibroblast-like synoviocytes (FLS) from RA patients. AT2R expression was strongly increased in RA compared with osteoarthritis (OA) synovium, as well as in in cultured RA-FLS respect to OA-FLS and healthy FLS. Treatment with pro-inflammatory cytokines was able not only to boost AT2R expression in RA-FLS and OA-FLS, but also to induce its de novo expression in healthy FLS. The stimulation of AT2R with the specific agonist CGP42112A significantly reduced gene expression of interleukin (IL)-1β and IL-6 and activation of NF-κB in RA-FLS, while opposite effects were elicited by AT2R small interfering RNA. Moreover, AT2R agonism efficiently decreased RA-FLS proliferation and migration either at baseline or under pro-inflammatory cytokine challenge. In conclusion, AT2R is strongly expressed in key effector cells of rheumatoid synovitis, namely RA-FLS, and the activation of AT2R with a specific agonist may effectively dampen their pro-inflammatory and aggressive behavior. AT2R agonism might represent a novel therapeutic strategy for patients with RA