15 research outputs found
First approaches in the study of cytotoxic and mutagenic damage induced by cold aqueous extract of Baccharis articulata on normal cells
Species of Genus Baccharis (Asteraceae) possess various bioactivities in vitro. The aim was to determine the cytogenotoxic activity of the cold aqueous extract (CAE) of Baccharis articulata. Peripheral blood lymphocytes from healthy individuals were in vitro faced to CAE (40, 78, 156, 313, 625 and 1250 ug/mL) for 18-24 h. Toxicity was evaluated by staining of trypan blue exclusion and MTT reduction. The genotoxicity was evaluated by the Micronucleus Test. Balb/c mice were injected with CAE (1800, 900 and 450 mg/kg), saline solution and cyclophosphamide as negative and positive controls respectively.
Animals were sacrificed at 6 h post-injection. Bone marrow samples were fixed and stained with May- GrĂŒnwald and Giemsa. Two thousand polychromatic erythrocytes (PCE) were counted to determine number
of micronuclei (MN) and normochromatic erythrocytes (NCE)/250 PCE to calculate toxicity index (TI). CAE toxicity on human lymphocytes was dose-dependent (Cytotoxic concentration 50% = 150 ug/mL). The
number of MNPCE for negative control was: 5 (+1), positive control: 372 (+23) and CAE in three doses: 26 (+8), 16 (+5) and 8 (+3). TI for negative control: 1.38 (+0.35) positive control: 3.1 (+1.06) and CAE in three doses: 0.78 (+0.05), 0.82 (+0.08) and 1.21 (+0.2). CAE treatment showed no statistical difference respect to negative control. CAE of B articulata was not cytogenotoxic.Fil: Cariddi, Laura Noelia. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Escobar, Franco Matias. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Sabini, Maria Carola. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Torres, Cristina Vanesa. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Evaluation of Cytotoxicity and Genotoxicity of Acacia aroma Leaf Extracts
Acacia aroma, native plant from San Luis, Argentina, is commonly used as antiseptic and for healing of wounds. The present study was conducted to investigate the in vitro cytotoxicity and genotoxicity of hot aqueous extract (HAE) and ethanolic extract (EE) of A. aroma. The cytotoxic activity was assayed by neutral red uptake assay on Vero cell. Cell treatment with a range from 100 to 5000 g/mL of HAE and EE showed that 500 g/mL and 100 g/mL were the maximum noncytotoxic concentrations, respectively. The CC50 was 658 g/mL for EE and 1020 g/mL for HAE. The genotoxicity was tested by the single-cell gel electrophoresis comet assay. The results obtained in the evaluation of DNA cellular damage exposed to varied concentrations of the HAE showed no significant genotoxic effect at range of 1â20 mg/mL. The EE at 20 mg/mL showed moderate genotoxic effect related to the increase of the DNA percentage contained in tail of the comet; DNA was classified in category 2. At concentrations below 5 mg/mL, the results of cytotoxicity and genotoxicity of aqueous and ethanolic extracts of Acacia aroma guarantee the safety at cell and genomic level. However further studies are needed for longer periods including animal models to confirm the findings.Fil: Mattana, Claudia Maricel. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia; ArgentinaFil: Cangiano, Maria de Los Angeles. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Alcaraz, MarĂa Luciana. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Sosa, A.. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia; ArgentinaFil: Escobar, Franco Matias. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Sabini, C.. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales; ArgentinaFil: Laciar, Analia Liliana. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia; Argentin
Efecto del aceite esencial de Minthostachys verticillata sobre la respuesta inmune de pacientes alérgicos a åcaros del polvo
El aceite esencial de hojas de M. verticillata fue obtenido por destilaciĂłn en corriente de vapor y analizado por cromatografĂa gaseosa. CĂ©lulas mononucleares de sangre perifĂ©rica de pacientes alĂ©rgicos, fueron estimuladas con aceite esencial. La proliferaciĂłn fue ensayada mediante mĂ©todo colorimĂ©trico del MTT o 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide. Se cuantificaron cĂ©lulas CD4 + , CD8 + y B en cultivos de linfocitos y en sobrenadantes, IFN- Îł e IL-13. Se determinĂł la liberaciĂłn de la enzima ÎČ -hexosaminidasa de basĂłfilos adicionados de aceite esencial, y desafiados con el alergeno. Los efectos del aceite esencial fueron comparados con los de drogas antialĂ©rgicas. Los principales constituyentes identificados fueron pulegona, mentona y limoneno. Aceite esencial incrementĂł los valores de cĂ©lulas CD4 + , CD8 + y B (p<0.002), estimulĂł la sĂntesis de IFN- Îł y redujo los niveles de IL-13. El aceite esencial disminuyĂł la liberaciĂłn de ÎČ -hexosaminidasa de basĂłfilos (p<0.0001) con mayores efectos que los de las drogas ensayadas. Aceite esencial estimulĂł la desviaciĂłn Th1 y redujo la liberaciĂłn de la enzima ÎČ -hexosaminidasa de basĂłfilos de pacientes alĂ©rgicos.The essential oil from leaves of Minthostachys verticillata was obtained by steam distillation and analyzed by gas chromatography. Peripheral blood mononuclear cells from allergic patients were stimulated with essential oil. By application of MTT or 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide colorimetric test the proliferation was assayed. In lymphocyte cultures CD4+, CD8+ and B cells were quantified, and in supernatants, IFN-Îł and IL-13. The liberation of ÎČ-hexosaminidase enzyme was determined for basophils with essential oil added and challenged with allergen and its effects were compared with those of anti-allergic drugs. The main constituents identified were pulegone, menthone and limonene. Essential oil increased absolute values of CD4+, CD8+ and B cells (p<0.002), stimulated IFN-Îł synthesis and reduced IL-13 levels. Essential oil diminished ÎČ-hexosaminidase liberation by basophils (p<0.0001), with effects majors to those of the drugs tested. Essential oil stimulated the Th1 deviation and reduced ÎČ-hexosaminidase enzyme liberation by basophils from allergic patientsFil: Cariddi, Laura Noelia. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Moser, Marina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Andrada, Melisa. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Demo, Mirta Susana. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Maldonado, Ana Maria. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Verbascum thapsus: Antifungal and phytotoxic properties
Verbascum thapsus (Schrophulariaceae) better known as Mullein is a medicinal plant used in the treatment of inflammatory diseases, asthma, spasmodic cough, diarrhea, and other pulmonary problems. The objective of this study was to evaluate the effect of V. thapsus extracts on fungal plant pathogens growth and seed germination. Verbascum thapsus leaves were treated with n-hexane, chloroform, methanol, cold and warm water to obtained the extracts. Antifungal activity was observed mainly in the methanol extract (1000 ”g mL-1) against Fusarium graminearum and Macrophomina phaseolina. Furthermore, results show that the hexane, cold and warm aqueous extract favored or had no toxic effect on Lycopersicon esculentum and Triticum aestivum seeds germination and growth, while the chloroform and methanol extracts affected negatively the germination.Fil: Vogt, Maria Veronica. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de BiologĂa Molecular; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; ArgentinaFil: Cravero, Carolina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de BiologĂa Molecular; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Luis. Instituto de Investigaciones en TecnologĂa QuĂmica. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia. Instituto de Investigaciones en TecnologĂa QuĂmica; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Rosas, Susana Beatriz. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de BiologĂa Molecular; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentin
Action of extracts obtained with organic solvents from Minthostachys verticillata(Griseb.) Epling on viability of Herpes simplex Type 1 virus (HSV-1)
It has demonstrated âin vitroâ antimicrobial activity exerted by extracts from Minthostachys verticillata (peperina). Objective: Investigate antiviral action of organic extracts of peperina against Herpes simplex virus. Experimental: Vero cells and Herpes simplex virus type 1 strain KOS were used. Aerial vegetal parts of plant were submitted to sequential extraction with n-hexane, chloroform and methanol for 48 h at room temperature. Extracts n-hexanic (N-HE), chloroformic (CE) and methanolic (ME) were obtained. They were added on cell monolayers, and incubated for 48 h at 37°C. Cell viability was determinated by Neutral Red uptake (NRU) after treatment of cells with different concentrations of extracts (10-1000 ÎŒg/ml). The same method was performed to evaluate antiviral action exerted by N-HE (100-250 ÎŒg/ml), CE (100-500 ÎŒg/ml) and ME (range 80-200 ÎŒg/ml). Results and discussion: The three extracts showed dose-dependent cytotoxic activity on Vero cells with CC50 values: 502 ÎŒg/ml for CE, 244 ÎŒg/ml for N-HE and 192 ÎŒg/ml for ME. The replication of Herpes simplex virus type 1 âin vitroâ was inhibited by each extract at non cytotoxic concentrations. The extracts showed selectivity of action because all concentrations tested inhibited more than 60% of viral production. The results are promising for future natural therapy antiherpetic.Fil: Sabini, Maria Carola. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Cariddi, Laura Noelia. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; ArgentinaFil: Escobar, Franco Matias. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Tonn, Carlos Eugenio. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Luis. Instituto de Investigaciones en TecnologĂa QuĂmica. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia. Instituto de Investigaciones en TecnologĂa QuĂmica; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de CĂłrdoba. Facultad de Medicina. Instituto de VirologĂa Dr. J. M. Vanella; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Reactive oxygen species-mediated degradation of antidiabetic compounds: Cytotoxic implications of their photodegradation products
Reactive oxygen species (ROS) have been described in their double physiological function, helping in the maintenance of health as well as contributing to oxidative stress. Diabetes mellitus is a chronical disease nearly related to oxidative stress, whose treatment (in type II variant) consists in the administration of antidiabetic compounds (Andb) such as Gliclazide (Gli) and Glipizide (Glip). In this context, as Andb may be exposed to high ROS concentrations in diabetic patients, we have studied the potential ROS-mediated degradation of Gli and Glip through photosensitized processes, in the presence of Riboflavin (Rf) vitamin. We found that singlet oxygen (O 2 ( 1 â g )) participated in the Rf-sensitized photodegradation of both Andb, and also superoxide radical anion in the case of Gli. Two principal products derived from O 2 ( 1 â g )-mediated degradation of Gli were identified and their chemical structures characterized, through HPLC mass spectrometry. O 2 ( 1 â g )-mediated degradation products and their toxicity was assayed on Vero cell line. These studies demonstrated that neither Gli nor its photoproducts caused cytotoxic effect under the experimental conditions assayed. Our results show strong evidences of ROS-mediated Andb degradation, which may involve the reduction or loss of their therapeutic action, as well as potential cytotoxicity derived from their oxidation products.Fil: Challier, Cecilia. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de BiologĂa Molecular; ArgentinaFil: Laurella, Sergio Luis. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Centro de QuĂmica InorgĂĄnica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de QuĂmica InorgĂĄnica "Dr. Pedro J. Aymonino"; ArgentinaFil: Allegretti, Patricia Ercilia. Universidad Nacional de La Plata; ArgentinaFil: Sabini, Maria Carola. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Garcia, Norman Andino. Universidad Nacional de RĂo Cuarto; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Biasutti, Maria Alicia. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; Argentina. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Criado, Susana Noemi. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; Argentina. Universidad Nacional de RĂo Cuarto; Argentin
Minthostachys verticillata essentials oil and its major components: antiherpetic selective action in HEp-2 cells
The medicinal herb Minthostachys verticillata was studied in various fields of natural medicine. Numerous studies were made to evaluate its antimicrobial properties. This work emphasizes in the analysis of the antiviral capacity of its Essential Oil (EO). The aim of this study was to determine the Therapeutic Index (TI) of the EO and its main chemical components. Suid herpesvirus type 1 or Pseudorabies virus (Prv) was proliferated in HEp-2 cells in presence of non-toxic concentrations of the oily samples. Antiviral action was quantified by reducing the number of plaques of lysis. Previously, the cytotoxicity of the samples was evaluated and 50% Cytotoxic Concentration values (CC50) were determined. The TI was calculated by relating the cytotoxic concentrations of each sample vs. those concentrations active against the virus. The results showed that the major components of the EO were pulegone, menthone and limonene, with CC50 of 352, 835 and 1155 ÎŒg/mL respectively vs. the CC50 of EO: 613 ÎŒg/mL. The antiviral action was exerted by pulegone and the EO at concentrations 20 to 30 times lowers than the toxic concentrations. These IT values show the possible applicability of these compounds because they exert selective antiviral action.Fil: Vogt, Maria Veronica. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de BiologĂa Molecular; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; ArgentinaFil: Sutil, Sonia Beatriz. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Escobar, Franco Matias. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Sabini, Maria Carola. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Cariddi, Laura Noelia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Torres, Cristina Vanesa. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Zanon, Silvia Matilde. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Antiviral effect and mode of action of methanolic extract of Verbascum thapsus L. on pseudorabies virus (strain RC/79)
The methanolic extract of Verbascum thapsus was evaluated for its antiviral activity against the pseudorabies virus strain RC/79 (PrV), and also for its cytotoxic activity on Vero cells. The extract showed CC50 values of 1100gmL1 and 1426gmL1 by NRU and MTT assays, respectively. The 50% inhibitory concentration of the extract for PrV plaque formation was determined at 35gmL1, and selectivity indices were 31.4 (NRU) and 40.7 (MTT). When cells were pre-treated with the extract prior to virus infection, the inhibition in plaque formation was 70%. PrV was highly inhibited when it was incubated with plant extract or when the extract was added during the adsorption phase (99%). However, no inhibitory effect was observed when the extract was added to the cells after the adsorption period. Thus, these results suggest that the methanolic extract of Verbascum thapsus may contain bioactive compound(s) that affect PrV mostly in the adsorption phase.Fil: Escobar, Franco Matias. Universidad Nacional de Rio Cuarto. Facultad de Agronomia y Veterinaria. Instituto de Ciencias Veterinarias. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Ciencias Veterinarias.; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Sabini, Maria Carola. Universidad Nacional de CĂłrdoba; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Zanon, Silvia Matilde. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - San Luis. Instituto de Investigaciones en TecnologĂa QuĂmica. Universidad Nacional de San Luis. Facultad de QuĂmica, BioquĂmica y Farmacia. Instituto de Investigaciones en TecnologĂa QuĂmica; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Study of antiviral and virucidal activities of aqueous extract of Baccharis articulata against Herpes suis virus
Baccharis articulata is native of AmĂ©rica and traditionally used for the treatment of digestive disorders and urinary infections. Cytotoxicity of aqueous extracts of B. articulata was investigated in Vero cells. As the maximal non cytotoxic concentration has been established, this concentration has been used to evaluate antiviral and virucidal activities against Herpes suis virus type 1, member of the same subfamily of Herpes simplex virus. Aqueous extracts of B. articulata exhibited more than 95% of virucidal activity. These findings support their potential application as a disinfectant or antiseptic with low toxicity and provide a valuable knowledge to ethnopharmacology properties of Baccharis articulata.Fil: Torres, Cristina Vanesa. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: DomĂnguez, MarĂa Julia. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Carbonari, JosĂ© Luis. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Sabini, Maria Carola. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de CĂłrdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; ArgentinaFil: Zanon, Silvia Matilde. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas, FisicoquĂmicas y Naturales. Departamento de MicrobiologĂa e InmunologĂa; Argentin
Inhibition of immediate-type allergic reaction by Minthostachys verticillata (Griseb.) epling essential oil
An oil of Minthostachys verticillata (Griseb.) Epling was analyzed by GC. The main constituents identified were pulegone (63.0%) and menthone (16.4%). It was found that the oil inhibited ÎČ-hexosaminidase release from basophils. Forty-two percent of the cells present in lymphocyte cultures stimulated by the oil were CD8(+) T cells and showed higher IFN-Îł levels than non-stimulated cultures (p < 0.05). According to these results, the oil was considered to be a Th1 deviation inducer, inhibiting the immediate-type allergic reaction. © 2007, Taylor & Francis Group, LLC. All rights reserved.Fil: Cariddi, Laura Noelia. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Panero, Adriana. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Demo, Mirta Susana. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Sabini, Liliana Ines. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Maldonado, Ana Maria. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Grosso, Margarita. Universidad Nacional de RĂo Cuarto; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto Multidisciplinario de BiologĂa Vegetal. Universidad Nacional de CĂłrdoba. Facultad de Ciencias Exactas FĂsicas y Naturales. Instituto Multidisciplinario de BiologĂa Vegetal; Argentin