1,096 research outputs found
Marble burying as compulsive behaviors in male and female mice
Marble burying is considered an, albeit controversial, animal model of the compulsive like behaviors of obsessive‑compulsive disorder (OCD). Hallmark features of OCD patients are similarities and, more prominent, differences from anxiety disorders, e.g., the absence of sex differences and resistance to spontaneous remission. We report an experiment on marble burying by male and female C57/BL6/N mice. Animals were administered either the classic anxiolytic drug, diazepam, that targets the GABA receptor or a "pure" inhibitor of the serotonin transporter, escitalopram, that has been reported to be particularly effective in OCD. A burying paradigm that more precisely mimics the human condition was used, e.g., testing in the home environment, chronic drug exposure and acknowledging individual differences by pre‑selecting for high marble burying. Results were that there were no sex differences in groups treated with drugs or in control mice. Both diazepam and escitalopram decreased numbers of marbles buried compared to vehicle‑only controls in the absence of correlated changes in anxiety. Diazepam, however, was more effective than escitalopram in suppressing MB. The conclusion is that along with serotonin, GABA is involved in regulating compulsive behaviors. The marble burying paradigm may prove more useful for pharmacological drugs tests of impulsivity or attention deficit because of the involvement of serotonin and GABA in both disorders
Nanostructured Melt-Spun Sm(Co,Fe,Zr,B)7:5 Alloys for High-Temperature Magnets
High coercivity, the highest for Cu-free 2 : 17 Sm-Co ribbons, has been
obtained in as-spun (= 211 kOe) and short time annealed (= 232 kOe) samples of
Sm(CobalFe Zr B)7 5 alloys, with varying B, Zr, and Fe content (= 0-0 06, = 0-0
16, = 0 08-0 3) and wheel speed. In as-spun samples, the TbCu7 type structure
and in annealed samples the Th2Zn17 and CaCu5 type structures is observed, plus
fcc Co as minority phase is observed. Reduced remanence () is higher than 0.7.
High-temperature magnetic measurements show very good stability above 300 C
with coercive field as high as 5.2 kOe at 330 C. For annealed Sm(CobalFe0 3Zr0
02B0 04)7 5, very good loop squareness and high maximum energy product of 10.7
MGOe have been obtained. Increasing Zr content results in less uniform
microstructure of annealed ribbons.Comment: IEEE Transactions on Magnetics, Vol. 39, No. 5, pages 2869 - 2871,
September 200
1864-09-15 Major George W. Sabine recommends promotion of Captain William S. Clark
https://digitalmaine.com/cw_me_1st_heavy_corr/1294/thumbnail.jp
1864-09-19 Major George Sabine writes G.F. Talbot regarding efforts to block his brother Thomas\u27 appointment as Lieutenant Colonel
https://digitalmaine.com/cw_me_1st_heavy_corr/1296/thumbnail.jp
1863-07-05 George W. Sabine recommends Private George Brewer for promotion to Lieutenant
https://digitalmaine.com/cw_me_1st_heavy_corr/1095/thumbnail.jp
1863-11-15 Major George W. Sabine recommends Orderly Sergeant Gershom Bibber for promotion
https://digitalmaine.com/cw_me_1st_heavy_corr/1134/thumbnail.jp
1863-11-03 Captain George Sabine sends the returns for Company K
https://digitalmaine.com/cw_me_1st_heavy_corr/1130/thumbnail.jp
1863-01-08 Captain George W. Sabine forwards recommendation for his promotion from the officers of the 18th Maine Regiment
https://digitalmaine.com/cw_me_1st_heavy_corr/1041/thumbnail.jp
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