Annual Site Environmental Report: 2008 (ASER)

This report provides information about environmental programs during the calendar year of 2008 at the SLAC National Accelerator Laboratory (SLAC), Menlo Park, California. Activities that span the calendar year, i.e., stormwater monitoring covering the winter season of 2008/2009 (October 2008 through May 2009), are also included. Production of an annual site environmental report (ASER) is a requirement established by the United States Department of Energy (DOE) for all management and operating (M&O) contractors throughout the DOE complex. SLAC is a federally-funded research and development center with Stanford University as the M&O contractor. Under Executive Order (EO) 13423, Strengthening Federal Environmental, Energy, and Transportation Management, and DOE Order 450.1A, Environmental Protection Program, SLAC effectively implements and integrates the key elements of an Environmental Management System (EMS) to achieve the site's integrated safety and environmental management system goals. For normal daily activities, SLAC managers and supervisors are responsible for ensuring that policies and procedures are understood and followed so that: (1) Worker safety and health are protected; (2) The environment is protected; and (3) Compliance is ensured. Throughout 2008, SLAC continued to improve its management systems. These systems provided a structured framework for SLAC to implement 'greening of the government' initiatives such as EO 13423 and DOE Orders 450.1A and 430.2B. Overall, management systems at SLAC are effective, supporting compliance with all relevant statutory and regulatory requirements. SLAC continues to demonstrate significant progress in implementing and integrating EMS into day-to-day operations and construction activities at SLAC. The annual management review and ranking of environmental aspects were completed this year by SLAC's EMS Steering Committee, the Environmental Safety Committee (ESC), and twelve objectives and targets were established for 2008. For each objective and target, a work plan, or Environmental Management Program (EMP) was completed and progress reports were routinely provided to SLAC senior management and the DOE SLAC Site Office (SSO). During 2008, there were no reportable releases to the environment from SLAC operations. In addition, many improvements in waste minimization, recycling, stormwater management, groundwater restoration, and SLAC's chemical management system (CMS) were continued during the year. The following are amongst SLAC's environmental accomplishments for 2008: a composting program at SLAC's onsite cafeteria was initiated, greater than 800 cubic feet of legacy radioactive waste were packaged and shipped from SLAC, a chemical redistribution program was developed, SLAC reduced the number of General Services Administration leased vehicles from 221 to 164, recycling of municipal waste was increased by approximately 140 tons during 2008, and site-wide releases of sulfur hexafluoride were reduced by 50 percent. In 2008, no radiological incidents occurred that increased radiation levels or released radioactivity to the environment. In addition to managing its radioactive wastes safely and responsibly, SLAC worked to reduce the amount of waste generated. SLAC has implemented programs and systems to ensure compliance with all radiological requirements related to the environment. Specifically, the Radiation Protection Radiological Waste Management Group developed a training course to certify Radioactive Waste Generators, conducted a training pilot, and developed a list of potential radioactive waste generators to train. Twenty eight generators were trained in 2008. As a best management practice, SLAC also reduced its tritium inventory by at least 95 percent by draining one of its accelerator cooling water systems; with the cooperation of the South Bayside System Authority, the West Bay Sanitary District and the DOE, SLAC discharged the cooling water to the sanitary sewer according to federal regulations and replenished the system with clean water. In 2008, the SLAC Environmental Restoration Program personnel continued work on site characterization and evaluation of remedial alternatives at four sites with volatile organic compounds in groundwater and several areas with polychlorinated biphenyls and low concentrations of lead in soil. SLAC is regulated under a site cleanup requirements order (board order) issued by the California Regional Water Quality Control Board (RWQCB), San Francisco Bay Region in May 2005 for the investigation and remediation of impacted soil and groundwater at SLAC. The board order lists specific tasks and deadlines for completion of groundwater and soil characterization and other remediation activities. All 2008 submittals to the RWQCB were completed and submitted on time

Annual Site Environmental Report, 2007(ASER)

This report provides information about environmental programs during the calendar year (CY) of 2007 at the Stanford Linear Accelerator Center (SLAC), Menlo Park, California. Activities that span the calendar year, i.e., stormwater monitoring covering the winter season of 2007/2008 (October 2007 through May 2008), are also included. Production of an annual site environmental report (ASER) is a requirement established by the United States Department of Energy (DOE) for all management and operating (M&O) contractors throughout the DOE complex. SLAC is a federally-funded research and development center with Stanford University as the M&O contractor. Under Executive Order (EO) 13423 and DOE Order 450.1, 'Environmental Protection Program', SLAC effectively implemented and integrated the key elements of an Environmental Management System (EMS) to achieve the site's integrated safety and environmental management system goals. For normal daily activities, SLAC managers and supervisors are responsible for ensuring that policies and procedures are understood and followed so that: (1) Worker safety and health are protected; (2) The environment is protected; and (3) Compliance is ensured. Throughout 2007, SLAC focused on development and implementation of SLAC management systems to ensure continual improvement. These systems provided a structured framework for SLAC to implement 'greening of the government' initiatives such as EO 13148. Overall, management systems at SLAC are effective, supporting compliance with all relevant statutory and regulatory requirements. SLAC continues to demonstrate significant progress in implementing and integrating EMS into day-to-day operations at SLAC. The annual management review and ranking of environmental aspects were completed this year by SLAC's EMS Steering Committee, the Environmental Safety Committee (ESC) and thirteen objectives and targets were established for 2007. For each objective and target, a work plan, or Environmental Management Program (EMP) was completed and progress reports were routinely provided to SLAC senior management. During 2007, there were no reportable releases to the environment from SLAC operations. In addition, many improvements in waste minimization, recycling, stormwater management, groundwater restoration, and SLAC's chemical management system (CMS) were continued during 2007. SLAC replaced two process tanks at the Plating Shop which previously contained chromium solutions with non-chromium containing solutions, reducing the overall use of hazardous chemicals. In addition, 346 polychlorinated biphenyl (PCB)-contaminated capacitors were replaced with non-PCB capacitors, reducing the potential of a release of oil with PCBs during an event such as a fire or an earthquake. SLAC operates its industrial and sanitary wastewater management program in compliance with established permit conditions. During 2007, SLAC obtained a new facility-wide wastewater discharge permit which replaced four separate permits that were previously issued to SLAC. In 2007, no radiological incidents occurred that increased radiation levels or released radioactivity to the environment. In addition to managing its radioactive wastes safely and responsibly, SLAC worked to reduce the amount of waste generated. SLAC has implemented programs and systems to ensure compliance with all radiological requirements related to the environment. Specifically, the Radiation Protection Radiological Waste Management (RPRWM) Group developed a training course to certify Radioactive Waste Generators, conducted a training pilot, and developed a list of potential radioactive waste generators to train. In 2007, the SLAC Environmental Restoration Program continued work on site characterization and evaluation of remedial alternatives at four sites with volatile organic compounds in groundwater and several areas with polychlorinated biphenyls and low concentrations of lead in soil. SLAC is regulated under a site cleanup requirements order (board order) issued by the California Regional Water Quality Control Board (RWQCB), San Francisco Bay Region in May 2005 for the investigation and remediation of impacted soil and groundwater at SLAC. The board order lists specific tasks and deadlines for completion of groundwater and soil characterization and other remediation activities. All 2007 submittals to the RWQCB were completed and submitted on time

Annual Site Environmental Report: 2005

This report provides information about environmental programs during 2005 at the Stanford Linear Accelerator Center (SLAC). Seasonal activities that span calendar years are also included. Production of an annual site environmental report (ASER) is a requirement established by the United States Department of Energy (DOE) for all management and operating (M&O) contractors throughout the DOE complex. SLAC is a federally-funded research and development center with Stanford University as the M&O contractor. SLAC effectively applied environmental management in meeting the site's integrated safety and environmental management system (ISEMS) goals. For normal daily activities, all SLAC managers and supervisors are responsible for ensuring that proper procedures are followed so that: (1) Worker safety and health are protected; (2) The environment is protected; and (3) Compliance is ensured. Throughout 2005, SLAC focused on these activities through the SLAC management systems (described in Chapter 3). These systems were also the way SLAC approached implementing ''greening of the government'' initiatives such as Executive Order 13148. The management systems at SLAC are effective, supporting compliance with all relevant statutory and regulatory requirements. There were no reportable releases to the environment from SLAC operations during 2005. In addition, many improvements were continued during 2005, in waste minimization, recycling, stormwater drain system, groundwater restoration, and implementing a chemical management system (CMS) to better manage chemical use. Program-specific details are discussed

Dynamic identification of a strategic building of the sixties with a mixed structure

The present paper shows and discusses the results of the identification procedure applied to the building of the Municipality of Castellaneta, Taranto (Puglia, Italy). The case study has been chosen for its structural complexity; indeed, the building has been built in two successive phases, block A built between 1955 and 1957, and block B, for completion, presumably built between the years 1960 and 1961. Block A constitutes the main building and represents the original nucleus. The structure was subsequently subject to structural interventions to replace some load-bearing walls with steel beams. The building constituting block B, joined to the original body of the building, has a structure in load-bearing masonry, while the floors, more recently built, are also in brick-concrete, but with pre-cast prestressed joists. The dynamic response of the building was assessed through OMA (Operational Modal Analysis) identification technique which allows you to determine the properties of the structure in real operating conditions, without the need to interrupt the activities inside the structure itself. The structural excitement, therefore, is due only to the environmental condition. A 3D model was defined in PRO_SAP; the results obtained from the finite element model were subsequently compared with those obtained from the experimental model

Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism

The aim of this retrospective observational study was to evaluate whether adding liraglutide to lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means of improving weight and glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism and erectile dysfunction (ED) in a 'real-life setting'. Forty-three obese, diabetic and hypogonadal men (aged 45-59 years) were evaluated because of complaining about the recent onset of ED. They were subdivided into two groups according to whether hypogonadism occurred after puberty (G1; n = 30: 25 with dysfunctional hypogonadism and 5 with acquired hypogonadotropic hypogonadism) or before puberty (G2; n = 13: 10 with Klinefelter's syndrome and 3 with idiopathic hypogonadotropic hypogonadism). Both G1 and G2 patients were given a combination of testosterone (T) [testosterone undecanoate (TU) 1000 mg/every 12 weeks] and Met (2000-3000 mg/day) for 1 year. In the poor responders (N) to this therapy in terms of glycaemic target (G1N: n = 16; G2N: n = 10), liraglutide (L) (1.2 μg/day) was added for a second year, while the good responders (Y) to T + Met (G1Y: 14/30 and G2Y: 3/13) continued this two drugs regimen therapy for another year. All patients were asked to fill in the International Index of Erectile Function (IIEF 15) questionnaire before starting TU plus Met (T1) and after 12 months (T2) and 24 months (T3) of treatment. Patients underwent a clinical examination and a determination of serum sex hormone binding globulin (SHBG), total testosterone (T) and glycosylated haemoglobin (HbA1c) at T1, T2 and T3. At T2, each patient obtained an improvement of ED (p < 0.01) and of the metabolic parameters without reaching, however, the glycaemic goals [HbA1c = >7.5% (>58 mmol/mol)], while T turned out to be within the range of young men. L added to TU and Met regimen in G1N and G2N allowed these patients to reach not only the glycaemic target [HbA1c = <7.5% (<58 nmol/mol)] and a significant reduction in body weight (p < 0.01), but also a further increase in SHBG (p < 0.05) and T (p < 0.01) plasma levels as well as a significant increment of IIEF score (T3). Conversely, at T3 G1Y and G2Y, who received the combined therapy with TRT and Met for the second year, showed a partial failure of that treatment given that there was no improvement of the IIEF score and they showed a significant rise in serum HbA1c (p < 0.05) and weight (p < 0.04) compared with the assessments at T2. These results suggest that TRT could improve clinical and metabolic parameters in obese, type 2 diabetic men with ED and overt hypogonadism (independently of when T deficit occurred). Furthermore, in case of insufficient metabolic control the addition of L to TRT and Met regimen allows to achieve serum T levels in the range of healthy men, as well as to reach glycaemic target and to lower weight, leading to a considerable improvement of ED

Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer’s disease (AD) and the symptoms of advanced AD may represent a unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression are becoming mandatory. Among possible reversible risk factors of dementia and AD, vascular, metabolic, and lifestyle-related factors were associated with the development of dementia and late-life cognitive disorders, opening new avenues for the prevention of these diseases. Among diet-associated factors, coffee is regularly consumed by millions of people around the world and owing to its caffeine content, it is the best known psychoactive stimulant resulting in heightened alertness and arousal and improvement of cognitive performance. Besides its short-term effect, some case-control and cross-sectional and longitudinal population-based studies evaluated the long-term effects on brain function and provided some evidence that coffee, tea, and caffeine consumption or higher plasma caffeine levels may be protective against cognitive impairment/decline and dementia. In particular, several cross-sectional and longitudinal population-based studies suggested a protective effect of coffee, tea, and caffeine use against late-life cognitive impairment/decline, although the association was not found in all cognitive domains investigated and there was a lack of a distinct dose-response association, with a stronger effect among women than men. The findings on the association of coffee, tea, and caffeine consumption or plasma caffeine levels with incident mild cognitive impairment and its progression to dementia were too limited to draw any conclusion. Furthermore, for dementia and AD prevention, some studies with baseline examination in midlife pointed to a lack of association, although other case-control and longitudinal population-based studies with briefer follow-up periods supported favourable effects of coffee, tea, and caffeine consumption against AD. Larger studies with longer follow-up periods should be encouraged, addressing other potential bias and confounding sources, so hopefully opening new ways for diet-related prevention of dementia and AD

The First 1 1/2 Years of TOTEM Roman Pot Operation at LHC

Since the LHC running season 2010, the TOTEM Roman Pots (RPs) are fully operational and serve for collecting elastic and diffractive proton-proton scattering data. Like for other moveable devices approaching the high intensity LHC beams, a reliable and precise control of the RP position is critical to machine protection. After a review of the RP movement control and position interlock system, the crucial task of alignment will be discussed.Comment: 3 pages, 6 figures; 2nd International Particle Accelerator Conference (IPAC 2011), San Sebastian, Spain; contribution MOPO01

Dispersion-Theoretical Analysis of the Nucleon Electromagnetic Formfactors

Dispersion relations allow for a coherent description of the nucleon electromagnetic form factors measured over a large range of momentum transfer, $Q^2 \simeq 0 \ldots 35$ GeV$^2$. Including constraints from unitarity and perturbative QCD, we present a novel parametrisation of the absorptive parts of the various isoscalar and isovector nucleon form factors. Using the current world data, we obtain results for the electromagnetic form factors, nucleon radii and meson couplings. We stress the importance of measurements at large momentum transfer to test the predictions of perturbative QCD.Comment: 33 pp, RevTEX or plain LaTeX, 7 figures (in ffig.uu

Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian longitudinal study on aging

Introduction: Liver fibrosis increases progressively with aging and has been associated with poorer cognitive performance in middle-aged and older adults. We investigated the relationships between a non-invasive score for advanced liver fibrosis (non-alcoholic fatty liver disease [NAFLD] fibrosis score [NFS]) and dementia risk. We also assessed physical frailty, a common geriatric condition which is associated to dementia. We tested the joint effects of physical frailty and fibrosis on dementia incidence. Methods: A total of 1061 older adults (65 to 84 years), from the Italian Longitudinal Study on Aging, were prospectively evaluated for the risk of dementia in a period between 1992 and 2001. Liver fibrosis was defined according to the NFS. Physical frailty was assessed according to the Fried's criteria. Cox proportional hazards models were used to estimate the short- and long-term risk of overall dementia, associated to the NFS, testing the effect modifier of physical frailty status. Results: Older adults with only high NFS (F3-F4) did not exhibit a significant increased risk of overall dementia. Over 8 years of follow-up, frail older adults with high NFS had an increased risk of overall dementia (hazard ratio [HR]: 4.23; 95% confidence interval [CI]: 1.22 to 14.70, P = .023). Finally, physically frail older adults with low albumin serum levels (albumin < 4.3 g/dL) and with advanced liver fibrosis (F3-F4 NFS) compared to those with lower liver fibrosis score (F0-F2 NFS) were more likely to have a higher risk of overall dementia in a long term-period (HR: 16.42; 95% CI: 1.44 to 187.67, P = .024). Discussion: Advanced liver fibrosis (F3-F4 NFS) could be a long-term predictor for overall dementia in people with physical frailty. These findings should encourage a typical geriatric, multidisciplinary assessment which accounts also for the possible co-presence of frail condition in older adults with chronic liver disease and liver fibrosis

European Reference Network for Rare Vascular Diseases (VASCERN) position statement on cerebral screening in adults and children with hereditary haemorrhagic telangiectasia (HHT)

Hereditary haemorrhagic telangiectasia (HHT) is a multisystemic vascular dysplasia inherited as an autosomal dominant trait. Approximately 10 % of patients have cerebral vascular malformations, a proportion being cerebral arteriovenous malformations (AVMs) and fistulae that may lead to potentially devastating consequences in case of rupture. On the other hand, detection and treatment related-risks are not negligible, and immediate. While successful treatment can be undertaken in individual cases, current data do not support the treatment of unruptured AVMs, which also present a low risk of bleeding in HHT patients. Screening for these AVMs is therefore controversial. Structured discussions, distinctions of different cerebrovascular abnormalities commonly grouped into an "AVM"bracket, and clear guidance by neurosurgical and neurointerventional radiology colleagues enabled the European Reference Network for Rare Vascular Disorders (VASCERN-HHT) to develop the following agreed Position Statement on cerebral screening: 1) First, we emphasise that neurological symptoms suggestive of cerebral AVMs in HHT patients should be investigated as in general neurological and emergency care practice. Similarly, if an AVM is found accidentally, management approaches should rely on expert discussions on a case-by-case basis and individual risk-benefit evaluation of all therapeutic possibilities for a specific lesion. 2) The current evidence base does not favour the treatment of unruptured cerebral AVMs, and therefore cannot be used to support widespread screening of asymptomatic HHT patients. 3) Individual situations encompass a wide range of personal, cultural and clinical states. In order to enable informed patient choice, and avoid conflicting advice, particularly arising from non-neurovascular interpretations of the evidence base, we suggest that all HHT patients should have the opportunity to discuss knowingly brain screening issues with their healthcare provider. 4) Any screening discussions in asymptomatic individuals should be preceded by informed pre-test review of the latest evidence regarding preventative and therapeutic efficacies of any interventions. The possibility of harm due to detection of, or intervention on, a vascular malformation that would not have necessarily caused any consequence in later life should be stated explicitly. We consider this nuanced Position Statement provides a helpful, evidence-based framework for informed discussions between healthcare providers and patients in an emotionally charged area