Prediction of thyroid malignancy based on clinical, radiological and biochemical factors with emphasis on serum TSH.

Many patients present to the surgical department with a thyroid nodule. However not all require surgery and only 5-6% of these are malignant. There are many methods to diagnose and predict malignancy in a thyroid nodule. This study throws light on the usefulness of clinical, radiological and TSH estimation and its role in predicting malignancy. There is a definite relationship between higher TSH levels and malignancy. TSH levels could be used as predictor in clinically suspicious malignant thyroid swelling with a benign FNAC report. In such cases where TSH value is high, the FNAC can be relooked to confirm the diagnosis. In addition to TSH, clinical features such as lymphadenopathy, fixity, SNT, USG features such as hypoechoic, calcification, invasion to adjacent structures are also predictors of thyroid malignancy

Euclid:Validation of the MontePython forecasting tools

The Euclid mission of the European Space Agency will perform a survey of weak lensing cosmic shear and galaxy clustering in order to constrain cosmological models and fundamental physics. We expand and adjust the mock Euclid likelihoods of the MontePython software in order to match the exact recipes used in previous Euclid Fisher matrix forecasts for several probes: weak lensing cosmic shear, photometric galaxy clustering, the cross-correlation between the latter observables, and spectroscopic galaxy clustering. We also establish which precision settings are required when running the Einstein-Boltzmann solvers CLASS and CAMB in the context of Euclid. For the minimal cosmological model, extended to include dynamical dark energy, we perform Fisher matrix forecasts based directly on a numerical evaluation of second derivatives of the likelihood with respect to model parameters. We compare our results with those of other forecasting methods and tools. We show that such MontePython forecasts agree very well with previous Fisher forecasts published by the Euclid Collaboration, and also, with new forecasts produced by the CosmicFish code, now interfaced directly with the two Einstein-Boltzmann solvers CAMB and CLASS. Moreover, to establish the validity of the Gaussian approximation, we show that the Fisher matrix marginal error contours coincide with the credible regions obtained when running Monte Carlo Markov Chains with MontePython while using the exact same mock likelihoods. The new Euclid forecast pipelines presented here are ready for use with additional cosmological parameters, in order to explore extended cosmological models

Euclid:Validation of the MontePython forecasting tools

The Euclid mission of the European Space Agency will perform a survey of weak lensing cosmic shear and galaxy clustering in order to constrain cosmological models and fundamental physics. We expand and adjust the mock Euclid likelihoods of the MontePython software in order to match the exact recipes used in previous Euclid Fisher matrix forecasts for several probes: weak lensing cosmic shear, photometric galaxy clustering, the cross-correlation between the latter observables, and spectroscopic galaxy clustering. We also establish which precision settings are required when running the Einstein-Boltzmann solvers CLASS and CAMB in the context of Euclid. For the minimal cosmological model, extended to include dynamical dark energy, we perform Fisher matrix forecasts based directly on a numerical evaluation of second derivatives of the likelihood with respect to model parameters. We compare our results with those of other forecasting methods and tools. We show that such MontePython forecasts agree very well with previous Fisher forecasts published by the Euclid Collaboration, and also, with new forecasts produced by the CosmicFish code, now interfaced directly with the two Einstein-Boltzmann solvers CAMB and CLASS. Moreover, to establish the validity of the Gaussian approximation, we show that the Fisher matrix marginal error contours coincide with the credible regions obtained when running Monte Carlo Markov Chains with MontePython while using the exact same mock likelihoods. The new Euclid forecast pipelines presented here are ready for use with additional cosmological parameters, in order to explore extended cosmological models