21 research outputs found
Bone Marrow Fractionation by the Haemonetics System: Reduction of Red Cell Mass before Marrow Freezing, with Special Reference to Pediatric Marrow Volumes
Systematic Use of Leukocyte-Free Blood Components to Prevent Alloimmunization and Platelet Refractoriness in Multitransfused Children with Cancer
Reemphasis on Leukocyte Transfusions: Induction of Myeloid Marrow Recovery in Critically ill Neutropenic Children with Cancer
Clinical symptoms and IgE responses to common food proteins in atopic and healthy children
Human parvovirus B19-induced transient pancytopenia in a child with hereditary spherocytosis
Supplementary Material for: Integrated Analysis of Gene Copy Number, Copy Neutral LOH, and microRNA Profiles in Adult Acute Lymphoblastic Leukemia
We adopted an integrated analysis of gene copy number alterations (CNAs), copy number neutral loss of heterozygosity (CNN LOH), and microRNA (miRNA) profiling in 21 adult acute lymphoblastic leukemia (ALL) patients. This study revealed the most frequent CNAs to be at chromosomes 9p, 7, and 17 and recurrent CNN LOH at 5p, 9p, and Xq. As for the most differentially expressed miRNAs, they included 8 upregulated and 14 downregulated miRNAs, of which miR-148a at 7p15.2, miR-22 at 17p13.3, miR-223 at Xq12, as well as miR-101-2 at 9p24.1 exhibited recurrent CNAs or CNN LOH. miR-101-2 was recurrently downregulated, and although the related CNN LOH was detected only in <i>BCR-ABL1</i> negative cases (2/14), deletions of miR-101-2 were observed solely in <i>BCR-ABL1</i> positive cases (4/7). Finally, <i>BCR-ABL1</i> positive cases, in contrast to negative ones, were characterized by slightly, but still significantly, higher expression levels of miR-29b