5 research outputs found

    Severe Hypercalcemia Following Vitamin D Exposure in Infants, Underestimated Risk Associated with Supplement Use

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    <p>According to medical guidelines, newborns are often given vitamin D supplements. However, an overdose of diet D can result in life-threatening hypercalcemia.  </p><p>The article describes the case of a 3-month-vintage toddler who suffered from excessive hypercalcemia. After mother and father had been requested for clarification, an blunders within side the use of diet D became discovered.</p><p>The mother and father surely observed the midwives' advice. They changed the prescribed diet D with a complement of various power and dosage with out the want for dose conversion. In fact, there are numerous medicinal drugs and dietary supplements that include nutrition D and feature one-of-a-kind concentrations and measurements. This case highlights the important thing function of healing training. Overall, harmonization of the rules and labeling of nutritional dietary supplements and drugs containing nutrition D is necessary.</p&gt

    Vitamin D status and consequences of vitamin D deficiency

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    <p>Serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations are presently diagnosed because the useful repute indicator for diet D.Evidence is reviewed that suggests that serum 25(OH)D3 concentrations of < eighty nmol/L are related to decreased calcium absorption, osteoporosis, and accelerated fracture risk. For popular older individuals, supplemental oral intakes of ~1300 IU/d are required to obtain the lower end of the best range.Evidence of considerable issues in recurring medical size of serum 25(OH)D3 concentrations amongst sufferers is cited.There is extremely good want for standardization and advanced reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations.</p&gt

    Medication Errors by Nurses in the Emergency Department in Saudi Arabia: Causes, Consequences, and Prevention Strategies

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    <p>Medication errors pose a significant threat to patient safety in the emergency department in Saudi Arabia. Nurses play a vital role in mitigating these errors, but several factors contribute to their occurrence. By prioritizing adequate staffing levels, ongoing training and education, standardization of procedures, and the integration of technology, healthcare systems in Saudi Arabia can better address this issue. Ultimately, patient safety should be at the forefront of every healthcare provider's mind, and concerted efforts can significantly reduce medication errors in the emergency department.</p&gt

    Association of Serum Zinc and Inflammatory Markers with the Severity of COVID-19 Infection in Adult Patients

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    COVID-19 infection can spread in the host body without any adequate immune response. Zinc is an essential trace element with strong immunoregulatory and antiviral properties and its deficiency might lead to inflammation and oxidative stress. The aim of the current study was to determine the association of serum zinc and inflammatory markers with the severity of COVID-19 infection. This was a prospective observational study in which 123 COVID-19-positive adult patients and 48 controls were recruited. The initial comparative analysis was conducted between COVID-19 patients and controls. COVID-19-positive patients were further divided into three different groups (mild, moderate, and severe) based on the severity of COVID-19 infection. COVID-19 patients showed significantly lower serum zinc levels (8.8 ± 2.3 µmol/L) compared to healthy controls (11.9 ± 1.8 µmol/L). There was a negative correlation between serum zinc levels and the severity of COVID-19 infection (r = −0.584, p p < 0.0001). Furthermore, inflammatory markers showed a positive correlation with the severity of COVID-19 infection and a negative correlation with the levels of serum zinc. The study demonstrated an association between COVID-19 infection with low serum zinc levels and elevated inflammatory markers. Further studies to assess the significance of this observation are needed, which may justify zinc supplementation to mitigate the severity of COVID-19 infection

    Evaluation of solid-lipid nanoparticles formulation of methotrexate for anti-psoriatic activity

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    Background &amp; Objectives: Methotrexate (MTX) is commonly used to manage psoriasis. The drug has erratic absorption characteristics and shows several complications. The present study uses different experimental models to evaluate the solid-lipid nanoparticles of MTX (SLN-MTX) for the anti-psoriatic effect. Methods: A prepared SLN-MTX formulation was used and its permeability studies were conducted on Wistar rat abdominal skin. The organ-level distribution of the drug in the formulation was tested in mice and the in-vitro anti-psoriatic activity was determined in CL-177; XB-2 keratinocytes cell lines. The efficacy of SLN-MTX formulation was compared with standard MTX and marketed MTX preparations. The results are analyzed statistically using the student’s t-test. Results: The data suggested that MTX from the formulation was slowly released and completely (80.36%) permeated through the skin. The flux and permeation data were found to be maximum for SLN-MTX compared to marketed and standard preparations. MTX in the formulation was found to be distributed more in the liver (67.5%) and kidney (2.34%). Further, SLN-MTX formulation showed dose-dependent inhibition on the growth of keratinocytes, and the cytotoxic concentration (CTC50) was found to be the least (518 mcg/ml). Interpretation &amp; Conclusion: The findings suggested that MTX in solid-lipid nanoparticles could be a promising formulation for the management of psoriasis since the drug was slowly released, progressively inhibited the growth of keratinocytes, and distributed mostly in organs meant for elimination. More studies in this direction might establish the precise safety and efficacy of SLN-MTX formulation in psoriasis
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