Fiber-coupled light-emitting diode with a capillary-bonded hemispherical lens

A hemispherical lens capillary-bonded to an InGaN flip-chip light-emitting diode (LED) is demonstrated to efficiently couple light to a plastic optical fiber. The BK-7 hemispherical lens is bonded onto a circularly shaped LED chip with inclined sidewalls cut by laser-micromachining, so that lateral emissions are effectively suppressed. Capillary bonding minimizes air-gap between chip and lens enabling transmission of evanescent waves, thus maximizing overall optical transmission. With the lens attached, emission divergence from the assembly is significantly reduced, diverting rays into the acceptance cone of the fiber. Fiber coupling efficiency as high as 53.8% has been demonstrated. © 2011 IEEE.published_or_final_versio

Alcohol consumption and sleep problems in Hong Kong adolescents

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Cross-sectional difference in BMI between senior and junior students predicts prospective change in BMI at the school level

Poster Presentation: abstract no. 1196The Conference abstracts's website is located at http://www2.kenes.com/apccn/scientific/Pages/ListofAbstracts.aspxOBJECTIVES: To examine whether cross-sectional BMI difference between senior and junior secondary school students was correlated with prospective changes in BMI at the school level. BACKGROUND: Schools are known to exert prospective influences on adolescent BMI. The school effects may also be reflected in cross-sectional BMI differences between senior and junior students in each school. Schools could quickly be identified for weight-control interventions if such cross-sectional differences could predict prospective changes in BMI. METHODS: In the Hong Kong Student …postprin

Nitric oxide synthase (NOS) expression and nitric oxide (NO) production in CCL4-induced hepatotoxicity of rats

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Neuroprotective effects of lutein in a rat model of retinal detachment

Background: Retinal detachment (RD) is a leading cause of blindness, and although final surgical re-attachment rate has greatly improved, visual outcome in many macula-off detachments is disappointing, mainly because of photoreceptor cell death. We previously showed that lutein is anti-apoptotic in rodent models of ischemia/reperfusion injury. The objective of this study is to investigate lutein as a possible pharmacological adjunct to surgery. Methods: Subretinal injections of 1.4 % sodium hyaluronate were used to induce RD in Sprague-Dawley rats until their retinae were approximately 70 % detached. Daily injections of corn oil (control group) or 0.5 mg/kg lutein in corn oil (treatment group) were given intraperitoneally starting 4 h after RD induction. Animals were euthanized 3 days and 30 days after RD and their retinae were analyzed for photoreceptor apoptosis and cell survival at the outer nuclear layer (ONL) using TUNEL staining and cell counting on retinal sections. Glial fibrillary acidic protein (GFAP) and rhodopsin (RHO) expression were evaluated with immunohistochemistry. Western blotting was done with antibodies against cleaved caspase-3, cleaved caspase-8 and cleaved caspase-9 to delineate lutein's mechanism of action in the apoptotic cascade. To seek a possible therapeutic time window, the same set of experiments was repeated with treatment commencing 36 h after RD. Results: When lutein was given 4 h after RD, there were significantly fewer TUNEL-positive cells in ONL 3 days after RD when compared with the vehicle group. Cell counting showed that there were significantly more nuclei in ONL in lutein-treated retinae by day 30. Treatment groups also showed significantly reduced GFAP immunoreactivity and preserved RHO expression. At day 3 after RD, Western blotting showed reduced expression of cleaved caspase-3 and cleaved caspase-8 in the treatment group. No difference was found for cleaved caspase-9. When lutein was given 36 h after RD similar results were observed. Conclusions: Our results suggest that lutein is a potent neuroprotective agent that can salvage photoreceptors in rats with RD, with a therapeutic window of at least 36 h. The use of lutein in patients with RD may serve as an adjunct to surgery to improve visual outcomes. © 2012 The Author(s).published_or_final_versio

The existence of global weak solutions for a weakly dissipative Camassa-Holm equation in H1(R)

The existence of global weak solutions to the Cauchy problem for a weakly dissipative Camassa-Holm equation is established in the space C([0,∞)×R)nL∞([0,∞);H1(R)) under the assumption that the initial value u 0 (x) only belongs to the space H 1 (R) . The limit of viscous approximations, a one-sided super bound estimate and a space-time higher-norm estimate for the equation are established to prove the existence of the global weak solution

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.

Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of this receptor contributes to tumor growth. EGFR variant III (EGFRvIII) is the most commonly altered form of EGFR and contains a truncated ligand-binding domain. We previously reported that EGFRvIII is expressed in up to 40% of HNSCC tumors where it is associated with increased proliferation, tumor growth and chemoresistance to antitumor drugs including the EGFR-targeting monoclonal antibody cetuximab. Cetuximab was FDA-approved in 2006 for HNSCC but has not been shown to prevent invasion or metastasis. This study was undertaken to evaluate the mechanisms of EGFRvIII-mediated cell motility and invasion in HNSCC. We found that EGFRvIII induced HNSCC cell migration and invasion in conjunction with increased signal transducer and activator of transcription 3 (STAT3) activation, which was not abrogated by cetuximab treatment. Further investigation showed that EGF-induced expression of the STAT3 target gene HIF1-α, was abolished by cetuximab in HNSCC cells expressing wild-type EGFR under hypoxic conditions, but not in EGFRvIII-expressing HNSCC cells. These results suggest that EGFRvIII mediates HNSCC cell migration and invasion by increased STAT3 activation and induction of HIF1-α, which contribute to cetuximab resistance in EGFRvIII-expressing HNSCC tumors

The Effectiveness and Sustainability of a Universal School-Based Programme for Preventing Depression in Chinese Adolescents: A Follow-Up Study Using Quasi-Experimental Design

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Five times sit-to-stand test completion times among older women: Influence of seat height and arm position

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Exposure to particulate air pollution at different living locations and respiratory symptoms in Hong Kong-an application of satellite information

Respiratory ill-health effects due to particulate air exposure at different geographical locations in Hong Kong that aggregate individual living locations were estimated based on satellite information. We assessed the presence of respiratory symptoms of a frequent cough or sputum in school students aged 11-20 years old (n=9,881). Daily particulate air pollution levels at students' living locations were derived from the surface extinction coefficients measured by satellite and measurements from the air pollutant monitoring stations at ground level. Adjusted odds ratio (OR) [95% CI] of respiratory symptoms was 1.047 [1.005, 1.091] per 10 g m-3 increase in PM10 concentration. Specificity tests showed that adjusted OR of having other symptoms is not significant (p=0.20-0.94). Exposures to PM10 at different geographical locations is associated with increased odds of having respiratory symptoms (cough or sputum) but not with other symptoms unrelated to air pollution. © 2010 Taylor & Francis.postprin