Numerical Simulation of Waves and Calculation of Hydrodynamic characteristics Over different seawalls

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Web Search using Improved Concept Based Query Refinement

The information extracted from Web pages can be used for effective query expansion. The aspect needed to improve accuracy of web search engines is the inclusion of metadata, not only to analyze Web content, but also to interpret. With the Web of today being unstructured and semantically heterogeneous, keyword-based queries are likely to miss important results. . Using data mining methods, our system derives dependency rules and applies them to concept-based queries. This paper presents a novel approach for query expansion that applies dependence rules mined from a large Web World, combining several existing techniques for data extraction and mining, to integrate the system into COMPACT, our prototype implementation of a concept-based search engine

Leucocytosis after Post Traumatic Splenectomy: A Physiological Event or Indicator of Sepsis

BACKGROUND: Blunt injury abdomen causes a variety of injuries, the commonest being solid organ injury. Among the solid organs, the spleen is most commonly injured. Operative management plays a major role in treatment of blunt injury abdomen. Various postoperative complications can occur following emergency laparotomy including surgical site infection, abdominal abscess, urinary tract infection and lower respiratory tract infection. Diagnosing these infections becomes particularly challenging following splenectomy because of the unusual physiological response to leucocyte count and platelet count. The aim of this study is to assess the three risk factors i.e Total Leucocyte Count, Platelet count/Total Leucocyte Count Ratio and Injury Severity Score in patients undergoing splenectomy and to compare them with other patients undergoing laparotomies other than splenectomy for blunt injury abdomen in order to achieve a cut off value beyond which persistence of leucocytosis may denote infection. AIMS AND OBJECTIVES: 1. To study the WBC Count and Platelet Count (PC)/WBC Count ratio in infected and non infected individuals who have undergone post traumatic splenectomy compared to other blunt abdomen trauma patients who have undergone laparotomy. 2. To study the relationship of three prognostic factors : WBC count, PC/WBC count ratio and Injury Severity Score in individuals who have undergone emergency laparotomy after trauma and their role in post operative infection. MATERIALS AND METHODS: Study Centre: Institute of General Surgery, MMC and RGGGH, Chennai. Sample Size: 30cases of splenectomy/ 30 cases of blunt injury abdomen who underwent other laparotomies. Duration of Study: June 2017 to October 2018. Study Design: Prospective Observational Comparative Study. Inclusion Criteria: 1. All patients undergoing splenectomy after trauma. 2. Other blunt trauma patients who underwent laparotomy. Exclusion criteria: Patients undergoing splenectomy for reasons other than trauma. Assessment of parameters: WBC count, Platelet count, Injury Severity Score, Presence of postoperative infections such as pneumonia, abdominal abscess septicaemia, urinary tract and wound infections. RESULTS: The following are the results of the study: • Injury severity score >21 is a significant risk factor. • Post operative day 5 TC more than 15000 indicates infection. • PC/TC ratio < 20 on the 5th post operative day indicates infection. • Patients who underwent laparotomies other than splenectomy showed elevated Total count and Decreased platelet/total count ratio only if infected. • Presence of more than 1 risk factor is associated with 72% chance of infection. CONCLUSION: Post operative day 5 is the earliest time that infected and non infected patients can be distinguished on the basis of total count and PC/TC ratio. Risk factors for infection: Total count >15,000 on 5th post operative day, PC/TC ratio 21. • Presence of more than one risk factor carries 72% increased chance of infection and these patients should be monitored with high degree of suspicion. • Presence of increased total count and decreased platelet/total count on any post operative day in a patient who has undergone laparotomy other than splenectomy should be considered an indicator of infection and should be treated promptly

DNA barcoding to resolve phylogenetic relationship in Myristica spp.

Myristica is the largest and primitive genus of the taxonomically complex family Myristicaceae. DNA barcoding was used to study the evolutionary relationship between Myristica spp. and other genera of Myristicaceae. The barcoding loci namely, rbcL, matK, psbA-trnH, ITS and multilocus combinations were tested to assess their phylogenetic relationship. psbA-trnH locus revealed information regarding the relationship of species in Myristica genus. M. fragrans was found to be closely related to M. beddomei, M. amygdalina, M. andamanica1, whereas M. Fatua was found to be distinct from M. malabarica. Gymnocranthera and Knema species were found to share sister relation with other Myristica spp

Extent of Empowerment of Women Entrepreneurs on Entrepreneurial and Technological Empowerment

Empowerment of women entrepreneurs in the context of technology entails building up the abilities and skills of women to gain insight into the issues affecting them and also building up their capacity to voice their concerns. Technological empowerment of women entrepreneurs will open up avenues to further nrichment. By the use of technology women can broaden the scope of their activities. Hence the present paper focused on analyzing the entrepreneurial and technological empowerment of women entrepreneurs. Majority of the women entrepreneurs had medium level of entrepreneurial and low level of technological empowerment

A study of urinary tract infection in pregnancy and its effect on maternal and perinatal outcome

Background: Urinary tract infection (UTI) during pregnancy is very common in developing countries like India. UTI is caused by the growth of micro-organisms in the urinary tract. This study aims to determine the incidence of UTI in whole pregnancy and its adverse effects on mother and fetus. Methods: This is a prospective study conducted in outpatient department of ESIC medical college for one year from January 2017 to December 2017. A total of 182 pregnant women attending OBG OPD for ANC check-up without any medical disorders or previous adverse pregnancy outcomes of 18-35 years of age were included in the study. Urine routine and urine culture sensitivity were done for all. Results: Out of 182 pregnant women tested for UTI, the incidence of UTI in pregnancy was found to be 19%. Asymptomatic UTI was noted in 65% patients with UTI. Primigravida were commonly affected (56%). Highest cases were in 18 to 25 years (63%) age group. 56% cases showed 6-10 pus cells/HPF. Prevalence of UTI was more common in winter seasons. Commonest causative organism was E. coli in 38% cases. Maternal complications like anaemia (26%) and puerperal pyrexia (23%) were observed. Adverse fetal outcomes like preterm birth (35%) and fetal growth restriction (15%) were observed. Conclusions: In this study, the prevalence rate of UTI during pregnancy is high (19%). The physiological changes of pregnancy predispose the women to UTI so does the other factors such as age, sexual activity, hygiene, multiparty, previous history of UTI and socio-economic conditions. All pregnant women should be screened for UTI with a urine routine and urine culture, treated with antibiotics if the culture is positive and then retested for cure. Awareness has to be created about good hygienic practices and adequate hydration among pregnant women

A prospective study of efficacy of ultrasound guided transversus abdominis plane block for postcesarean analgesia

Background: The ultrasound guided transversus abdominis plane (TAP) block which provides effective analgesia after lower abdominal surgeries including caesarean section. It is a simple and reliable technique. In this prospective, randomized double-blind study, we determined the efficacy of TAP block using 0.25% Bupivacaine and 0.9N Saline with respect to VAS for pain, postoperative Tramadol consumption and post-operative ondansetron usage.Methods: This study was conducted on 100 adult patients of ASA physical status I and II in the   age group of 18 to 40 years undergoing elective lower segment cesarean section under spinal anaesthesia. Study group received TAP block with 0.25% Bupivacaine and control group received 10 ml of 0.9N saline on each side. Patients were analyzed for postoperative pain by pain score (at rest, on movement, on cough) using VAS was recorded at 0, ½, 1, 2, 4, 6, 12 and 24 hours postoperatively. Need for rescue analgesia was assessed by time to first dose of Tramadol requirement and total dose of Tramadol over 24 hours of postoperative period. Ondansetron (4 mg i.v.) was administered whenever nausea score was more than 2 or the patient vomited. All the data was noted using uniform performs.Results: Patients received TAP block with 0.25% Bupivacaine had better pain scores at first hour of postoperative period during rest, cough and movement which was statistically significant (p0.001).Conclusions: TAP block using ultrasound provides substantial reduction in Tramadol consumption, time to first dose of rescue tramadol when compared with control group. This study reinforces the recommendation for TAP as a part of multimodal post-operative analgesic regimen

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors.

Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our understanding of how non-coding genes change in this tumor is absent. This is an important area of research, as in many adult malignancies, non-coding genes including LNC-RNAs are used as biomarkers to predict outcome and/or relapse. To establish a complete and in-depth RNA profile, of both coding and non-coding genes, in Retinoblastoma tumors, we conducted RNA-seq from a cohort of tumors and normal retina controls. This analysis identified widespread transcriptional changes in the levels of both coding and non-coding genes. Unexpectedly, we also found rare RNA fusion products resulting from genomic alterations, specific to Retinoblastoma tumor samples. We then determined whether these gene expression changes, of both coding and non-coding genes, were also found in a completely independent Retinoblastoma cohort. Using our dataset, we then profiled the potential effects of deregulated LNC-RNAs on the expression of neighboring genes, the entire genome, and on mRNAs that contain a putative area of homology. This analysis showed that most deregulated LNC-RNAs do not act locally to change the transcriptional environment, but potentially function to modulate genes at distant sites. From this analysis, we selected a strongly down-regulated LNC-RNA in Retinoblastoma, DRAIC, and found that restoring DRAIC RNA levels significantly slowed the growth of the Y79 Retinoblastoma cell line. Collectively, our work has generated the first non-coding RNA profile of Retinoblastoma tumors and has found that these tumors show widespread transcriptional deregulation

The role of pregnancy-associated plasma protein-a level in the first trimester of pregnancy and clinical outcome in an urban referral centre

Background: Estimation of serum PAPP-A levels studied predictability for adverse perinatal outcome. This case control study tries to establish the association between low PAPP-A levels among the pregnant woman and adverse maternal foetal outcome.Methods: This is an case-control study during 2017-2018 in the women delivered at Department of OBG at Mehta Hospitals. Women delivered in the labour room  had a first trimester screening of PAPP-A level were explained, taken informed consent, questionnaire which include detailed antenatal history, mode of delivery and baby data.  Depending upon outcome, the subjects are classified as case group or control group, out of the study sample of 264 subjects, 88 patients who had complications were taken as cases and 176 patients with no complications taken as control were undertaken.Results: Low PAPP-A level (&lt;0.5 MoM) showed high incidence of PIH and preeclampsia, followed by IUGR and Preterm. PAPP-A level &gt;0.5 MoM, normal outcome is more than the adverse outcome. The difference in the PAPP-A levels is statistically significant. In women with low PAPP A level, low birth weight found statistically significant when compared with &lt;0.5 PAPP A level. The sensitivity of PAPP A levels in identifying the complicated outcomes was 17.04%.The specificity was 98.85%. The positive predictive value of predicting the complications was 88.23% and negative predictive value of 70.44%.Conclusions: The low PAPP-A levels confirmed during first trimester of pregnancy is associated with adverse maternal and foetal outcome such as PIH, preeclampsia, preterm, IUGR and LBW