Integrable twists in AdS/CFT

A class of marginal deformations of four-dimensional N=4 super Yang-Mills theory has been found to correspond to a set of smooth, multiparameter deformations of the S^5 target subspace in the holographic dual on AdS_5 x S^5. We present here an analogous set of deformations that act on global toroidal isometries in the AdS_5 subspace. Remarkably, certain sectors of the string theory remain classically integrable in this larger class of so-called gamma-deformed AdS_5 x S^5 backgrounds. Relying on studies of deformed su(2)_gamma models, we formulate a local sl(2)_gamma Lax representation that admits a classical, thermodynamic Bethe equation (based on the Riemann-Hilbert interpretation of Bethe's ansatz) encoding the spectrum in the deformed AdS_5 geometry. This result is extended to a set of discretized, asymptotic Bethe equations for the twisted string theory. Near-pp-wave energy spectra within sl(2)_gamma and su(2)_gamma sectors provide a useful and stringent test of such equations, demonstrating the reliability of this technology in a wider class of string backgrounds. In addition, we study a twisted Hubbard model that yields certain predictions of the dual beta-deformed gauge theory.Comment: v2: references and clarifications added, 46 page

Conformal Affine Toda Soliton and Moduli of IIB Superstring on AdS5×S5AdS_5\times S^5

In this paper we interpret the hidden symmetry of the moduli space of IIB superstring on $AdS_{5}\times S^{5}$ in terms of the chiral embedding in $AdS_{5}$, which turns to be the $\mathbb{CP}^{3}$ conformal affine Toda model. We review how the position $\mu$ of poles in the Riemann-Hilbert formulation of dressing transformation and how the value of loop parameters $\mu$ in the vertex operator of affine algebra determines the moduli space of the soliton solutions, which describes the moduli space of the Green-Schwarz superstring. We show also how this affine SU(4) symmetry affinize the conformal symmetry in the twistor space, and how a soliton string corresponds to a Robinson congruence with twist and dilation spin coefficients $\mu$ of twistor.Comment: Final version, Misprints corrected, Note adde

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types