Formation of an inactive substrate-Cu-Enzyme complex of xanthine oxidase

In the previous papers, it has been shown that the substrate inhibition of xanthine oxidase (xanthine: O2 oxidoreductase, EC 1. 2. 3. 2) induced by excess purines requires a small amount of exogenous metallic ions. Among these ions, Cu&#178;+ was the most typical one. At any stage of enzyme reaction, the inhibition began immediately on addition of a small amount of Cu&#178;+ such as 6.6 X 10-7 M. Since the depressed activity was not restored by the addition of chelating agents such as histamine and EDTA, it was suggested that the substrate, Cu&#178;+ and enzyme form a stable inactive enzyme complex, from which chelating agent can no longer remove Cu. The present communication describes the further investigations concerned with the formation of the substrate-enzyme complex in the presence of Cu&#178;+ and with the catalytic nature of this complex on other substrate and acceptor systems.</p

Image Reproduction based on Texture Image Extension with Traced Drawing for Heavy Damaged Mural Painting

AbstractNot only geometric information but also optical information is needed to reproduce ruins using three-dimensional realistic computer graphics as they were when those were founded. In order to give a model a sense of reality, it is common to carry out the texture mapping of the photographed image. However such information can not be acquired from either weathered or partially destroyed ruins. While there are various conventional techniques for image restoration, which can overcome in the case of small missing and cracks, it is difficult to restore such a heavy damaged mural painting well when there is no information from the periphery.In this paper, we propose an image reproduction of a heavy damaged mural painting using a texture information extracted from another mural painting which has actually been restored by conservators and a traced drawing which the specialist guessed and drew. The restored image was used same pigment inks. Based on texture information from the restored image and a segmented traced drawing, we produce a restored image by applying the texture extension to each segment

ベトナム社会主義共和国の口唇口蓋裂患者に対する医療協力の経験について : Odonto-Maxillo-Facial Center of Ho Chi Minh Cityにおける活動

We offered medical and technological assistance to cleft lip and palate patients at the Odonto-Maxillo-Facial Center of Ho Chi Minh City in Vietnam. We visited the hospital three times in two years from December, 1996 to December, 1998. We operated on 93 patients with cleft lip and/or palate, 2 patients with craniofacial microsomia, 2 patients with cheek defect caused by noma and 1 patient with von Reckinghasen\u27s disease. In Vietnam, there are many medical problems relating to cleft lip and palate patients, such as shortage of funds, medical disparity by regions and hospitals, insufficient numbers of oral surgeons and hospital beds for cleft lip and palate patients, and difficulty of obtaining new medical information from foreign countries. Most of these problems seemed doe to financial difficulties. For the present, medical assistance is necessary for the treatment of cleft lip and palate patients in Vietnam for the present

多数の静脈石を伴った巨大な舌血管腫の1例

A case of gigantic hemangioma of the tongue with numerous phlebohths is reported The patient was a 77-year-old woman with a chief complaint of eating disturbance due to the swollen mass of the tongue Intra-oral examination revealed a lobulated, well circumscribed gigantic tumor mass of the tongue measuring 62×61×49mm, purplish-red in color On palpation, the tumor was compressible, and had numerous phlebohths In the tumor, over fifty radiopaque phlebohths were detected and no influx vessels were observed by angiography The tumor was surgically excised and the postoperative course was uneventful

A Robin sequence patient treated by the tongue-lip adhesion technique of modified Argamaso method

われわれは八戸赤十字病院小児科から, Robin sequenceの生後12週男児の呼吸障害の改善のための対診を依頼された。患者は下顎後退,上気道閉塞,軟口蓋裂,舌小帯強直症がみられた。当科を受診前に,何度か重度の呼吸障害がみられ,2か月以上気管内挿管による呼吸管理か行われていた。患者の咽頭部の閉塞は,内規鏡検査によるSheyの分類のType 1であったため,われわれは生後15週でArgamaso変法による舌固定術を行った。術後2年5か月経過するが,以来患者にチアノーセは見られず,舌固定術は同患者に有効な治療法と思われた。A 12-week-old boy with Robin sequence was referred to us for respiratory improvement by a pediatrician in Hachmohe Red Cross Hospital The patient had micrognathia, upper airway obstruction, incomplete cleft palate and ankyloglossia The patient had a history of repeated cyanotic episodes and had been under respiratory care with endotracheal intubation for more than 2 months Using flexible fiber optic nasopharyngoscopy, his pharyngeal obstruction was classified as Type 1 of Sher\u27s classification Thus, we performed glossopexy of modified Argamaso method at 15 weeks after birth The patient has had no cyanotic episodes at 2 years and 5 months postoperatively We conclude that the glossopexy was effective for this patien

INSIDE THE SUN PYRAMID AT TEOTIHUACAN, MEXICO: 2008—2011 EXCAVATIONS AND PRELIMINARY RESULTS

After more than a century of explorations at the Sun Pyramid in Teotihuacan, many uncertainties about the function, meaning, chronology, and use of the monument remain unresolved. Here we present preliminary results from excavations and mapping conducted by the Sun Pyramid Project to address some of these issues. We focus particularly on describing the architectural features excavated in the interior of the pyramid as well as the subterranean tunnel. This evidence is used to argue that the subterranean structure was artificially constructed for ritual activities, including the placement of royal burials and/or offerings in its interior. We define three stages in the construction sequence of the Sun Pyramid: (1) a Pre-Sun Pyramid phase, (2) the establishment of the main corpus of the monument, and, finally, (3) the adjoining of the adosada platform. In each phase, we discuss the presence of burials, offerings, or other features uncovered. Furthermore, we present the results of new ceramic and radiocarbon dates that transform our understanding about the construction of the ceremonial center, where the Sun Pyramid and the subterranean tunnel are dated to a later phase than previously thought, from A.D. 170—310 and A.D. 140—240, respectively. Después de más de un siglo de exploraciones en la Pirámide del Sol en Teotihuacan, muchas incógnitas acerca de la función, el simbolismo, la cronología y el uso del monumento permanecen sin resolverse. Aquí presentamos los resultados preliminares de las excavaciones y el mapeo realizados por el Proyecto Pirámide del Sol para desentrañar algunas de estas cuestiones. Nos concentramos particularmente en la descripción de algunos rasgos arquitectónicos excavados en el interior de la pirámide, así como en la estructura subterránea, conocida como la cueva sagrada, que corre por debajo de dicha pirámide. Utilizamos esta evidencia para argumentar que la estructura subterránea fue construida artificialmente para actividades rituales, incluyendo la colocación de tumbas reales y/u ofrendas en su interior. Definimos tres etapas en la secuencia constructiva de la Pirámide del Sol incluyendo una fase pre-Pirámide del Sol, el establecimiento del núcleo principal del monumento, y finalmente la adición de la plataforma adosada. En cada fase se discute la presencia de entierros, ofrendas u otros rasgos descubiertos. Por otra parte, presentamos los resultados del nuevo fechamiento cerámico y de radiocarbono que transforman nuestra comprensión acerca de la construcción del centro ceremonial. Fechamos la pirámide y el túnel subterráneo para una fase más tardía de lo que se pensaba, 170—310 d.C. y 140—240 d.C. respectivamente

INSIDE THE SUN PYRAMID AT TEOTIHUACAN, MEXICO: 2008—2011 EXCAVATIONS AND PRELIMINARY RESULTS

After more than a century of explorations at the Sun Pyramid in Teotihuacan, many uncertainties about the function, meaning, chronology, and use of the monument remain unresolved. Here we present preliminary results from excavations and mapping conducted by the Sun Pyramid Project to address some of these issues. We focus particularly on describing the architectural features excavated in the interior of the pyramid as well as the subterranean tunnel. This evidence is used to argue that the subterranean structure was artificially constructed for ritual activities, including the placement of royal burials and/or offerings in its interior. We define three stages in the construction sequence of the Sun Pyramid: (1) a Pre-Sun Pyramid phase, (2) the establishment of the main corpus of the monument, and, finally, (3) the adjoining of the adosada platform. In each phase, we discuss the presence of burials, offerings, or other features uncovered. Furthermore, we present the results of new ceramic and radiocarbon dates that transform our understanding about the construction of the ceremonial center, where the Sun Pyramid and the subterranean tunnel are dated to a later phase than previously thought, from A.D. 170—310 and A.D. 140—240, respectively. Después de más de un siglo de exploraciones en la Pirámide del Sol en Teotihuacan, muchas incógnitas acerca de la función, el simbolismo, la cronología y el uso del monumento permanecen sin resolverse. Aquí presentamos los resultados preliminares de las excavaciones y el mapeo realizados por el Proyecto Pirámide del Sol para desentrañar algunas de estas cuestiones. Nos concentramos particularmente en la descripción de algunos rasgos arquitectónicos excavados en el interior de la pirámide, así como en la estructura subterránea, conocida como la cueva sagrada, que corre por debajo de dicha pirámide. Utilizamos esta evidencia para argumentar que la estructura subterránea fue construida artificialmente para actividades rituales, incluyendo la colocación de tumbas reales y/u ofrendas en su interior. Definimos tres etapas en la secuencia constructiva de la Pirámide del Sol incluyendo una fase pre-Pirámide del Sol, el establecimiento del núcleo principal del monumento, y finalmente la adición de la plataforma adosada. En cada fase se discute la presencia de entierros, ofrendas u otros rasgos descubiertos. Por otra parte, presentamos los resultados del nuevo fechamiento cerámico y de radiocarbono que transforman nuestra comprensión acerca de la construcción del centro ceremonial. Fechamos la pirámide y el túnel subterráneo para una fase más tardía de lo que se pensaba, 170—310 d.C. y 140—240 d.C. respectivamente

Regroupement des morts, monumentalité et sacrifice : l’ exemple de Teotihuacan (Mexique)

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