7 research outputs found
Viable mouse gene ablations that robustly alter brain Aβ levels are rare
- Author
- A Caccamo
- A Thathiah
- AB Goodman
- Antara Majumdar
- AS Espeseth
- AS Espeseth
- BP Zambrowicz
- BW Taron
- C Costantini
- C Costantini
- CE Hunt
- Charles F Albright
- CJ Phiel
- Daniel L Small
- DJ Selkoe
- DR Riddell
- E Kojro
- E Kojro
- E Tamagno
- E Tamagno
- E Tamagno
- F Fahrenholz
- G Zhu
- GJ Guillemin
- GJ Guillemin
- GJ Yohrling
- H Fukumoto
- H Tun
- IY Tamboli
- J Hamazaki
- J Hardy
- J Majercak
- J Nunan
- J Zhao
- J-H Zhang
- JE Meredith
- Jere E Meredith
- Jeremy H Toyn
- JM Cordy
- John Corradi
- JPT Corcoran
- K Sambamurti
- K Sambamurti
- KS Murayama
- KS Vetrivel
- L Desire
- L Pastorino
- L Serneels
- M Citron
- M Flajolet
- M Yamamoto
- Mark W Thompson
- MC Jonas
- Melissa Hansard
- Nestor Barrezueta
- NN Nalivaeva
- OM Andersen
- P Marambaud
- Q Jiang
- R Borghi
- R Dean
- R Etcheberrigaray
- R Li
- R Töpper
- RM Nitsch
- RMD Holsinger
- RO Weller
- Ryan S Westphal
- S Mandrekar
- S-C Kao
- SC Upadhya
- SE Hickman
- Sethu Sankaranarayanan
- SG Younkin
- SJ Grimme
- T O'Connor
- T Saito
- T Sakurai
- T Yao
- TA Lanz
- Thomas Lanthorn
- TL Kukar
- TMJ Allinson
- TW Stone
- Valerie Guss
- W He
- W He
- WMH Behan
- X Sun
- X Zhang
- Xu-Alan Lin
- Y Tong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Succinylpurines induce neuronal damage in the rat brain
- Author
- Publication venue
- PLENUM PRESS DIV PLENUM PUBLISHING CORP
- Publication date
- 01/01/1998
- Field of study
5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones
- Author
- A Chiarugi
- A Santamaria
- A Valencia
- AA Fatokun
- AJ Smith
- Andrew J. Smith
- AU Morita
- B Rotman
- CA Opitz
- CJ Clark
- CL Bellac
- CL Eastman
- CL Eastman
- CM Forrest
- F St’astny
- GM Mackay
- H Iwahashi
- H Kawasaki
- H Wei
- HQ Wu
- I Ferrer
- IM Medana
- LA Sanni
- LE Goldstein
- MN Perkins
- MP Heyes
- N Plesnila
- N Stoy
- P Guidetti
- P Guidetti
- P Guidetti
- P Popoli
- R Schwarcz
- R Schwarcz
- RM Kostrzewa
- Robert A. Smith
- S Okuda
- S Okuda
- SE Browne
- Trevor W. Stone
- TW Stone
- TW Stone
- V Chaparro-Huerta
- WMH Behan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
The essential amino acid tryptophan is primarily metabolised through the kynurenine pathway, some components of which may be neurotoxic. We have now examined the potential toxicity of several kynurenine metabolites in relation to the generation of oxidative stress and activation of cell death signalling pathways in cultured cerebellar granule neurons. 3-Hydroxykynurenine (3HK), 3-hydroxyanthranilic acid (3HAA) and 5-hydroxyanthranilic acid (5HAA) induced cell death which increased with exposure time and compound concentration. The neurotoxic effects of 3HK, 3HAA and 5HAA were prevented by catalase, but not by superoxide dismutase. In addition, Western blot analysis demonstrated p38 activation due to 3HK or 5HAA treatment, although caspase-3 activation was not evident in either case. The results indicate that kynurenine metabolites can be neurotoxic via a caspase-3 independent mechanism, and that the minor metabolite 5HAA is as potent a toxin as the better documented compounds 3HK and 3HA
Endogenous kynurenines as targets for drug discovery and development
- Author
- A Boireau
- A Chiarugi
- A Chiarugi
- A Chiarugi
- A Chiarugi
- A Giordani
- A Santamaria
- AG Chapman
- AJ Patton
- AM Franchi
- AM Maloney
- AM Sardar
- AMA Namboodiri
- AR Blight
- B Widner
- B Widner
- BL Harrison
- BM Baron
- C Hilmas
- C Itzstein
- C Kohler
- C Speciale
- CA Harris
- CD Weaver
- CL Eastman
- CR MacKenzie
- D Jauch
- D Sekkai
- DH Fitzgerald
- DH Munn
- DR Worthen
- E Savvateeva
- E Takeuchi
- EH Sinz
- ER Pfefferkorn
- F Guidetti
- F Heidempergher
- F Issa
- F Moroni
- F Moroni
- FC Ross
- G Ceresoli-Borroni
- G Henderson
- GA MacGibbon
- GJ Guillemin
- H Baran
- H Baran
- H Baran
- H Kazda
- H Okamoto
- H-Q Wu
- H-Q Wu
- HE Scharfman
- I Ghorayeb
- J Leon
- J Luthman
- J Varga
- JA Aquilina
- JB Gurdon
- JC Peters
- JE McGowan
- JH Connick
- JH Connick
- JJ Halperin
- JJ Kulagowski
- JK McCormack
- JL Walsh
- JM Carlin
- JP Kim
- JR Moffett
- K Dikranian
- K Takano
- KG Charlton
- L Carlock
- L Dong-Ruyl
- L Khaspekov
- LA Pemberton
- LA Sanni
- LE Goldstein
- LE Goldstein
- LFB Nicholson
- M Hattori
- MF Beal
- MF Beal
- MF Beal
- MG Espey
- MG Espey
- MN Perkins
- MP Heyes
- MP Heyes
- MP Heyes
- MP Heyes
- MP Heyes
- MP Heyes
- O Hansson
- P Guidetti
- P Guidetti
- P Guidetti
- P Milart
- P Rezaie
- P Russi
- PD Leeson
- PF Jackson
- PJ Birch
- R Carpenedo
- R Cozzi
- R Schwarcz
- R Schwarcz
- R Schwarcz
- RJ Brady
- RR Ramsay
- RW Kelly
- S Baratte
- S Erhardt
- S Erhardt
- S Okuda
- S Rover
- SJ Kerr
- SJ Pearson
- SK Gill
- SR Thomas
- SR Thomas
- SW Watts
- T Nicholls
- TD Johnson
- TM Skerry
- TW Stone
- TW Stone
- TW Stone
- TW Stone
- TW Stone
- V Politi
- W Rzeski
- WMH Behan
- WMH Behan
- WO Whetsell Jr
- Y Dang
- Y Kotake
- YM Bordelon
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2002
- Field of study
Promotion of cellular NAD+ anabolism: Therapeutic potential for oxidative stress in ageing and alzheimer’s disease
- Author
- A Bedalov
- A Brunet
- A Furukawa
- A Nunomura
- A Santamaria
- AA Sauve
- B Halliwell
- B Regland
- B Wolozin
- C Behl
- C Culmsee
- C Rios
- CC Alano
- CL Masters
- CM Grozinger
- CM Whitacre
- CP Ferri
- DA Butterfield
- DA Evans
- EM Blanc
- F Berger
- F Lisa di
- F Yeung
- G Liu
- GE Gibson
- GG Glenner
- Gilles Guillemin
- GJ Guillemin
- GJ Guillemin
- GJ Guillemin
- H Vaziri
- H Wang
- HA Kontos
- HC Lee
- HS Kim
- I Skoog
- J Luo
- J Zhang
- JA Serra
- JB Pillai
- JM Berg
- JM Mates
- JM Murcia de
- K Erdélyi
- K Ogino
- KT Howitz
- L Bordone
- LO Tjernberg
- M Citron
- M Malanga
- M Malanga
- M Miwa
- M PallĂ s
- M Porcu
- MA Smith
- MC Motta
- MC Raff
- ME Harris
- MG Miquel
- MP Heyes
- MP Mattson
- MS Parihar
- N Horwood
- Nady Braidy
- P Belenky
- P Jagtap
- P Pacher
- PD Maldonado
- PM Doraiswamy
- R Alvarez-Gonzalez
- R Ozcankaya
- R Rafaeloff-Phail
- RA Cherny
- RA Floyd
- RB Maccioni
- RG Meyer
- RM Anderson
- RN Martin
- Ross Grant
- RS Grant
- RW Gravey
- S Beneke
- S Doxsey
- S Finkbeiner
- S Love
- S Miranda
- S Oddo
- S Varadarajan
- SG Younkin
- SJ Berger
- SJ Kerr
- SJ Kerr
- SJ Lin
- SM Monte de la
- T Arraki
- T Jayasena
- T Ruscetti
- T Yang
- TW Stone
- VJ Bouchard
- W Ying
- WMH Behan
- X Huang
- X Zhu
- YH Suh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Adenosine receptors in neurological disorders
- Author
- ABBRACCHIO MP
- ABBRACCHIO MP
- ADAMI M
- AKBAR M
- ARSLAN G
- ARVIN B
- ASKALAN R
- BALDO BA
- BARAUDI PG
- BARONDES SH
- BIBB JA
- BIBER K
- BONA E
- CALABRESI P
- CHEN JF
- CHEN JF
- CHEN JF
- COMMISSARIS RL
- CONSTENLA AR
- CUI JG
- CUNHA RA
- DE M
- DE SARRO GB
- DIONISOTTI S
- DIXON AK
- DUNWIDDIE TV
- DUNWIDDIE TV
- EKONOMOU A
- EL YACOUBI M
- EL YACOUBI M
- FEOKISTOV I
- FEOKTISTOV I
- FERRE' S
- FIEBICH BL
- FIENBERG AA
- FINK JS
- FIORINO DF
- FLORIO C
- FLORIO C
- FORSYTHE P
- FREDHOLM BB
- FUXE K
- GONCALVES ML
- GREENGARD P
- GRONDIN R
- GUBIYZ AK
- GUIDETTI P
- HARAGUCHI H
- HAUBER W
- HIRSH EC
- IKEMOTO S
- IMPAGNATIELLO F
- JACOBSON KA
- JACOBSON KA
- JACOBSON KA
- JACOBSON MA
- JAIN N
- JIN S
- JOHANSSON B
- JOHANSSON B
- KAELIN-LANG A
- KAFKA SH
- KAPLAN GB
- KEMP N
- KESSEY K
- KOOB GF
- KOWALUK EA
- KOWALUK EA
- KULL B
- KULL B
- KUROKAWA M
- KYOSSEVA SV
- LEE C
- LEE YW
- LIBERATORE GT
- LINDEN J
- LINDSAY EA
- LINDSKOG M
- LOGAN M
- MACGREGOR DG
- MANDHANE SN
- MARQUART DL
- MARSTON HM
- MARTIN GE
- MATHERNE GP
- MCDONALD C
- MENDELSON W
- MET YA
- MEYERHOF W
- MOGUL DJ
- MONOPOLI A
- MONOPOLI A
- MORELLI M
- MORELLI M
- NIKODIJEVIC O
- OKADA M
- OLAH M
- ONGINI E
- ONGINI E
- ONGINI E
- PAGONOPOULOU O
- PALMER TM
- PEAKMAN MC
- PHILLIS JW
- PHILLIS JW
- PHILLIS JW O&
- PIERCE KD
- POPOLI P
- PORKKA-HEISKANEN T
- POUCHER SM
- PUFFINBARGER NK
- RALEVIC V
- RIBEIRO JA
- RICHARSON PJ
- RIMONDINI R
- RIVKEES SA
- RIVKEES SA
- ROBERTSON GS
- ROSIN DL
- RUDOLPHI KA
- SAHRAEI H
- SAJJADI FG
- SALIM H
- SATOH S
- SAWYNOK J
- SCHWIERIN B
- SEGERDAHL M
- SELF DW
- SHIMADA J
- SONG WJ
- STEHLE JH
- STONE TW BEHAN WMH
- SUZUKI F
- SVENNINGSSON P
- SVENNINGSSON P
- SVENNINGSSON P
- SVENNINGSSON P
- SVENNINGSSON P
- TURGEON SM
- VARANI K
- VARANI K
- VON HEIJNE M
- VON LUBITZ DK
- VON LUBITZ DK
- VON LUBITZ DKJE
- VON LUBITZ DKJE
- WEAVER DR
- WEISNER J
- YAKEL JL
- YAN Z
- YOUNG D
- ZHANG G
- ZHOU QY
- ZOCCHI C
- Publication venue
- 'Informa Healthcare'
- Publication date
- Field of study
Kolon und Rektum
- Author
- A Allan
- A Azmy
- A Balsam
- A Baril
- A Cabrera
- A Etzioni
- A Galian
- A Ghani
- A González-Angulo
- A Hafferl
- A Hey
- A Jørgensen
- A JĂĽnemann
- A King
- A Kiss
- A Lasser
- A Martins
- A Medline
- A Prakash
- A Schussheim
- A Schussheim
- A Shafik
- A Shaked
- A Singh
- A Takeuchi
- A Takeuchi
- A Talerman
- A Vogel
- A Wagner
- A Wagner
- Aa Johansen
- AA Keshgegian
- AA Mihas
- AA Mihas
- AA Moss
- AB Hood
- AB Price
- AB Price
- AB Price
- AC Beali Jr
- AC Mayr
- AD Newcomer
- ADR Northeast
- AE Alfonso
- AF Schärli
- AG McPherson
- AG Schreiber
- AH Herman
- AH James
- AH Kalla
- AH Qizilbash
- AH Qizilbash
- AI Mendeloff
- AI Mendeloff
- AJ Barson
- AJ Cass
- AJ Coup
- AJ Greenstein
- AJ Greenstein
- AJ Greenstein
- AJ Greenstein
- AJ Greenstein
- AJ Greenstein
- AJ Padilla
- AJ Wilmot
- AJM Boulton
- AJM Boulton
- AKM Shamsuddin
- AL McKee
- AL Viteri
- AL Warshaw
- AL Watne
- AL Watne
- AM Dvorak
- AM Dvorak
- AM Dvorak
- AM Holschneider
- AM Rywlin
- AM Shamsuddin
- AMO Veale
- AN Ani
- AN Charney
- AO Fayemi
- AP Kirk
- AP Maskens
- AP Maskens
- APR Aluwihare
- AR Altman
- AR Brown
- AR Chang
- ARC Butson
- ARP Walker
- AS McFee
- AS McNeish
- AS Mee
- AS Pieterse
- AT Shockman
- AW Behbehani
- AW Ulin
- B Bigelow
- B Blenn
- B Doberauer
- B Duncan
- B Eriksson
- B Eriksson
- B Fadda
- B Genter
- B Haskell
- B Heule van den
- B Heymer
- B Hillemand
- B Jones
- B Lindberg
- B Löhr
- B MacPherson
- B Miller
- B Ravo
- B Sischy
- B Stamm
- B Werner
- B Wiebecke
- B Wiebecke
- B Wiebecke
- B Wiebecke
- BA Barron
- BB Scott
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BC Morson
- BD Lake
- BE Crawford
- BI Korelitz
- BI Korelitz
- BI Korelitz
- BI Korelitz
- BI Korelitz
- BI Rees
- BJ Cedermark
- BJ Wilson
- BK Lucak
- BK Mandai
- BK Rao
- BL Leppard
- BL Schmitz
- BML Kapur
- BP Colcock
- BP Kalani
- BS Cuderman
- BS Danes
- BS Rabin
- BW Codling
- C Boulay Du
- C Cho
- C Dukes
- C Grodsinsky
- C Lan
- C Lindström
- C Ming-Chai
- C Owyang
- C O’Mara
- C Restrepo
- C Sinclair-Smith
- C Wagner
- C Yeshaya
- CA Athanasoulis
- CA Rubio
- CA Rubio
- CA Sheldon
- CAV Burt
- CB Croft
- CB Ernst
- CC Adolphson
- CC Huntley
- CC Norland
- CD Humphrey
- CE Haycock
- CEH Boulay Du
- CF Garagliano
- CF Genre
- CG Lindström
- CG Marks
- CH Park
- CH Ramirez-Ronda
- CH Webb
- ChHK Fung
- Chr Herfarth
- CJ Burul
- CJ Friedman
- CJ Longaker
- CJ Martin
- CJ McClain
- CJLM Meijer
- CK Bedard
- CK Tang
- CL Cutajar
- CL White III
- CM Fenoglio
- CM Fenoglio
- CM Surawicz
- CM Surawicz
- CO Metzmaker
- CP Bambach
- CP Willoughby
- CP Willoughby
- CR Sachatello
- CR Travieso Jr
- CS Foster
- CT Jewell
- CW Chow
- D Bardsley
- D Bartolo
- D Berkowitz
- D Birnbaum
- D Braverman
- D BĂĽttner
- D Cade
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- D Dennhardt
- D Guttman
- D Göbel
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- D Löhlein
- D Miranda
- D Mona
- D Pinter
- D Schmähl
- D Schottenfeld
- D Simonowitz
- D Simonowitz
- D Siroospour
- D Stein
- D Thorning
- D Walb
- D West
- DA Legge
- DA Lieberman
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- DB Doman
- DB MĂ©nard
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- DG Hopkins
- DG Sheahan
- DG Thompson
- DH Batts
- DJ Abramson
- DJ Allison
- DJ Glotzer
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- DJ Krogstad
- DJ O’Connell
- DJ Schoetz Jr
- DK Hossfeld
- DL Fowler
- DL Morris
- DL Schwartz
- DM Goldenberg
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- DM Steinberg
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- DM Wayte
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- DP Launer
- DR Antonow
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- DR Cave
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- DT Hunter Jr
- E Azizi
- E Cabal
- E Foucar
- E Frimberger
- E Guthy
- E Hancke
- E Hancke
- E Hancke
- E Hancke
- E Jacobs
- E Kassira
- E Kraft
- E Lovett
- E Lovett
- E MĂĽhe
- E Okamoto
- E Pihl
- E ProĂź
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- E Schrumpf
- E Schrumpf
- E Shalev
- ED Holyoke
- EG Boss
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- EI Kahn
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- EJ Gardner
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- EJ Holmes
- EJ Yunis
- EL Wynder
- EM Izsak
- EM Sykes
- EMM Quigley
- EN Castagnoli
- EO Riecken
- ER Rabin
- ER Richens
- ESR Hughes
- EW Martin Jr
- EW Naylor
- EW Taylor
- F Borchard
- F Borchard
- F Brahme
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- F Kern
- F KĂĽmmerle
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- F Paulino
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- G Antonakopoulos
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- H Akasura
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- N Henning
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- U Bettendorf
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- U Schiller
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- U Töllner
- U Ă–hman
- UA Almagro
- V Becker
- V Becker
- V EchavOĂ©
- V Grouls
- V Lenner
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- V Viranuvatti
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- VC Talwalker
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- VT Caldarola
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- VW Fazio
- W Bartelheimer
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- W Oehlert
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- W Oehlert
- W Oehlert
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- W Remmele
- W Renimele
- W Renimele
- W Röllinghoff
- W Rösch
- W Schennach
- W Schwarzkopf
- W Stock
- W Strauss
- W-P Fung
- WA Schuchardt Jr
- WB Stewart
- WC McGarity
- WCh Hecker
- WE Enker
- WE Strodel
- WE Strodel
- WF Caspary
- WF Caspary
- WF Ganong
- WF Grigioni
- WF Hickey
- WG Thompson
- WHO
- WI Wolff
- WI Wolff
- WJ Byrne
- WJ Collins
- WJ Dodds
- WJ Wood
- WK Blenkinsopp
- WL Buntain
- WL Donegan
- WL George
- WL Groff
- WM Buchanan
- WM Castleden
- WMH Behan
- WO Dobbins
- WP Homan
- WP Mazier
- WR Best
- WR Burnham
- WR Burnham
- WR Johnson
- WR Johnson
- WR Rout
- WS Haubrich
- WS Haubrich
- WS Haubrich
- WS Haubrich
- WS Haubrich
- WS Haubrich
- WS Haubrich
- WS Selby
- WT Cooke
- WT Miller
- WV Bogomoletz
- WV Bogomoletz
- WW Walton
- Y Charpentier Le
- Y Rosen
- Y Shoenfeld
- Y Wolloch
- Y-TN Lee
- YS Chiu
- Z CsapĂł
- ZD Goodman
- ZD Goodman
- ZD Yiotsas
- Ă… Andersson
- Ă… Andersson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study