Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils.

Submitted by Nuzia Santos ([email protected]) on 2018-03-22T15:22:36Z No. of bitstreams: 1 Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils.pdf: 632690 bytes, checksum: 042a1b2676ed88146463bd92d80209e8 (MD5)Approved for entry into archive by Nuzia Santos ([email protected]) on 2018-03-22T15:56:44Z (GMT) No. of bitstreams: 1 Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils.pdf: 632690 bytes, checksum: 042a1b2676ed88146463bd92d80209e8 (MD5)Made available in DSpace on 2018-03-22T15:56:44Z (GMT). No. of bitstreams: 1 Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils.pdf: 632690 bytes, checksum: 042a1b2676ed88146463bd92d80209e8 (MD5) Previous issue date: 2017Universidade Federal de São João Del Rei. Divinópolis, MG, BrazilUniversidade Federal de São João Del Rei. Divinópolis, MG, BrazilUniversidade Federal de São João Del Rei. Divinópolis, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto Rene Rachou. René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de São João Del Rei. Divinópolis, MG, BrazilFatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6-500 µg/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 μg/mL against Candida glabrata and C. krusei and 31.2 μg/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity

Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin

Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with a commercial antibiotic streptomycin. Phytol was a compound identified in all extracts by GC/MS, being majoritary component in Plectranthus barbatus and Rosmarinus officinalis. The Gram-positive bacteria were more sensitive to ethanol extracts, and Plectranthus barbatus and Rosmarinus officinalis were the most active extracts. Ethanol extracts exhibited a synergetic effect with streptomycin. These results encourage additional studies, in order to evaluate the possibilities of using ethanol extracts of Lamiaceae family as natural source for antibacterial activity

Antibacterial activity of Lamiaceae plant extracts in clinical isolates of multidrug-resistant bacteria

ABSTRACT The antibacterial activity of plant extracts of the Lamiaceae family was evaluated against clinical isolates of multi-resistant Gram-negative bacteria by broth microdilution technique. Promising results were obtained considering that all extracts were active for at least two bacterial species with MIC ranging from 0.5 to 2.0 mg/mL