Correcting calf girth discriminates the incidence of falling but not bone mass by broadband ultrasound attenuation in elderly female subjects.

Calf circumference has been cited as an independent risk factor for hip fracture. Correcting this measured girth for subcutaneous adipose tissue or fluid accumulation provides a more valid estimate of lean tissue, but has not been reported in elderly populations. Two hundred eighty-eight randomly selected female volunteers, aged ≥ 70 years, were assessed by quantitative ultrasound (QUS) and clinical risk factors as part of a larger screening study for hip fracture risk. This involved measuring broadband ultrasound attenuation (BUA) and administering a structured risk factor questionnaire that included estimated daily skeletal loading (time standing or walking). Body mass index (BMI) was estimated using current body mass and height at age 25 years. Calf girth was measured using a standard anthropometric tape, the medial calf skinfold (a vertical fold at the point of maximum calf girth) was measured, and corrected calf girth (CCG) was calculated by subtracting the skinfold (in centimeters) multiplied by π from calf girth. Subjects were aged 76.9 ± 5.0 years, had BMIs of 24.3 ± 3.9 kg/m2, and spent an average of 5.5 ± 2.0 h on their feet each day. Age, current body mass, BMI calf girth, and CCG all correlated with BUA (p 0.05). Dividing the sample into tertiles by these correlates of BUA and predicting BUA using stepwise regression revealed different predictors for each tertile. Of the total sample, 93 had fallen in the last 12 months, whereas 195 had not. Independent t-tests showed these groups to be similar in age, BMI, and calf girth (p > 0.05), but fallers spent less time on their feet each day, and had smaller CCG (p < 0.05). This suggests that larger calf muscles may be protective against falling—possibly as a result of enhanced stability or greater neuromuscular control

Minimal disconnected cuts in planar graphs

The problem of finding a disconnected cut in a graph is NP-hard in general but polynomial-time solvable on planar graphs. The problem of finding a minimal disconnected cut is also NP-hard but its computational complexity is not known for planar graphs. We show that it is polynomial-time solvable on 3-connected planar graphs but NP-hard for 2-connected planar graphs. Our technique for the first result is based on a structural characterization of minimal disconnected cuts in 3-connected K 3,3 -free-minor graphs and on solving a topological minor problem in the dual. We show that the latter problem can be solved in polynomial-time even on general graphs. In addition we show that the problem of finding a minimal connected cut of size at least 3 is NP-hard for 2-connected apex graphs

Flow interactions with an aquatic macrophyte: a field study using stereoscopic particle image velocimetry

This paper reports the morphology of a natural patch of Ranunculus penicillatus and presents high-resolution measurements of flow velocities in its wake using a stereoscopic PIV field measurement system. The patch was 3.80 m long, 1.24 m wide and caused substantial changes to downstream mean velocities and turbulence. Vertical profiles of streamwise mean velocity were not logarithmic and flow was redirected under the positively buoyant canopy, enhancing vertical turbulent mixing in the wake and generating a large region where the velocity covariance u'w' was positive. Turbulent kinetic energy was enhanced downstream from the patch lateral shear layer, but not at the centre of the wake. Spectra downstream from the patch showed that turbulence was neither dominated by fine-scale nor large-scale structures, likely due to the low energy of the flow conditions and lack of a developed vortex street within the measurement domain. Sedimentation was observed at the upstream end of the patch, but not underneath the floating canopy. The methods and results of this work will be useful for planning other in situ studies. Also, the reported data on macrophyte geometry and biometrics will assist with the design of more realistic replicas for use in laboratory studies

E-learning as a tool for knowledge transfer through traditional and independent study at two UK higher educational institutes: a case study

Much has been made of the advances in computer aided learning activities. Websites, virtual campus, the increased use of Web CT and chat rooms and further advances in the use of WebCT are becoming more commonplace in UK universities. This paper looks for ways of changing higher education students’ perception of the usefulness of recommended internet web sites for learning purposes, with the intention of increasing the usage rate of recommended module web-sites. The change could represent an adaptation of the existing, well-known technology to change students’ perception regarding its potentially formative role. Subsequently, the outcomes from this preliminary research could be used in order to enhance the quality of the Internet use for teaching and learning purposes

Increased risk of lower limb osteoarthritis among former professional soccer (football) players

Background: Soccer is a high-speed contact sport with risk of injury. Despite long-standing concern, evidence to date remains inconsistent as to the association between playing professional-level soccer and lifelong musculoskeletal consequences. Aims: The objectives were to assess risk of osteoarthritis in former professional soccer players compared to matched general population controls, and subsequently assess associated musculoskeletal disorders which may contribute to, or result from, osteoarthritis—specifically meniscal injury and joint replacement. Methods: We conducted a retrospective cohort study using national electronic health records (EHRs) on a cohort of 7676 former professional soccer players aged 40 or over at recruitment, matched on year of birth, sex (all male) and socio-economic status with 23 028 general population controls. Outcomes of interest were obtained by utilizing individual-level record linkage to EHRs from general hospital inpatient and day-case admissions. Results: Compared to controls, former soccer players showed a greater risk of hospital admission for osteoarthritis (hazard ratio [HR] 3.01; 95% confidence interval [CI] 2.80–3.25; P &lt; 0.001). This increased risk appeared age dependant, normalizing over age 80 years and reflective of increased risk of lower limb osteoarthritis. Further, risk of hospital admissions for meniscal injury (HR 2.73; 95% CI 2.42–3.08; P &amp;lt; 0.001) and joint replacement (HR 2.82; 95% CI 2.23–3.57; P &amp;lt; 0.001) were greater among former soccer players. Conclusions: We report an increased risk of lower limb osteoarthritis in former soccer players when compared with matched population controls. The results of this research add data in support of lower limb osteoarthritis among former soccer players representing a potential industrial injury

Virus shapes and buckling transitions in spherical shells

We show that the icosahedral packings of protein capsomeres proposed by Caspar and Klug for spherical viruses become unstable to faceting for sufficiently large virus size, in analogy with the buckling instability of disclinations in two-dimensional crystals. Our model, based on the nonlinear physics of thin elastic shells, produces excellent one parameter fits in real space to the full three-dimensional shape of large spherical viruses. The faceted shape depends only on the dimensionless Foppl-von Karman number \gamma=YR^2/\kappa, where Y is the two-dimensional Young's modulus of the protein shell, \kappa is its bending rigidity and R is the mean virus radius. The shape can be parameterized more quantitatively in terms of a spherical harmonic expansion. We also investigate elastic shell theory for extremely large \gamma, 10^3 < \gamma < 10^8, and find results applicable to icosahedral shapes of large vesicles studied with freeze fracture and electron microscopy.Comment: 11 pages, 12 figure

Localized f electrons in CexLa1-xRhIn5: dHvA Measurements

Measurements of the de Haas-van Alphen effect in CexLa1-xRhIn5 reveal that the Ce 4f electrons remain localized for all x, with the mass enhancement and progressive loss of one spin from the de Haas-van Alphen signal resulting from spin fluctuation effects. This behavior may be typical of antiferromagnetic heavy fermion compounds, inspite of the fact that the 4f electron localization in CeRhIn5 is driven, in part, by a spin-density wave instability.Comment: 4 pages, 4 figures, submitted to PR

Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation

Loss-of-function mutations of GNA11, which encodes G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone (PTH) concentrations, and normal or low urinary calcium excretion. A mouse model for FHH2 that would facilitate investigations of the in vivo role of Gα11 and the evaluation of calcimimetic drugs, which are CaSR allosteric activators, is not available. We therefore screened DNA from > 10,000 mice treated with the chemical mutagen N-ethyl-N-nitrosourea (ENU) for GNA11 mutations and identified a Gα11 variant, Asp195Gly (D195G), which downregulated CaSR-mediated intracellular calcium signaling in vitro, consistent with it being a loss-of-function mutation. Treatment with the calcimimetic cinacalcet rectified these signaling responses. In vivo studies showed mutant heterozygous (Gna11+/195G) and homozygous (Gna11195G/195G) mice to be hypercalcemic with normal or increased plasma PTH concentrations and normal urinary calcium excretion. Cinacalcet (30mg/kg orally) significantly reduced plasma albumin-adjusted calcium and PTH concentrations in Gna11+/195G and Gna11195G/195G mice. Thus, our studies have established a mouse model with a germline loss-of-function Gα11 mutation that is representative for FHH2 in humans and demonstrated that cinacalcet can correct the associated abnormalities of plasma calcium and PTH

Dual Vortex Theory of Strongly Interacting Electrons: Non-Fermi Liquid to the (Hard) Core

As discovered in the quantum Hall effect, a very effective way for strongly-repulsive electrons to minimize their potential energy is to aquire non-zero relative angular momentum. We pursue this mechanism for interacting two-dimensional electrons in zero magnetic field, by employing a representation of the electrons as composite bosons interacting with a Chern-Simons gauge field. This enables us to construct a dual description in which the fundamental constituents are vortices in the auxiliary boson fields. The resulting formalism embraces a cornucopia of possible phases. Remarkably, superconductivity is a generic feature, while the Fermi liquid is not -- prompting us to conjecture that such a state may not be possible when the interactions are sufficiently strong. Many aspects of our earlier discussions of the nodal liquid and spin-charge separation find surprising incarnations in this new framework.Comment: Modified dicussion of the hard-core model, correcting several mistake