Direct and indirect signals of natural composite Higgs models

We present a comprehensive numerical analysis of a four-dimensional model with the Higgs as a composite pseudo-Nambu-Goldstone boson that features a calculable Higgs potential and protective custodial and flavour symmetries to reduce electroweak fine-tuning. We employ a novel numerical technique that allows us for the first time to study constraints from radiative electroweak symmetry breaking, Higgs physics, electroweak precision tests, flavour physics, and direct LHC bounds on fermion and vector boson resonances in a single framework. We consider four different flavour symmetries in the composite sector, one of which we show to not be viable anymore in view of strong precision constraints. In the other cases, all constraints can be passed with a sub-percent electroweak fine-tuning. The models can explain the excesses recently observed in $WW$, $WZ$, $Wh$ and $\ell^+\ell^-$ resonance searches by ATLAS and CMS and the anomalies in angular observables and branching ratios of rare semi-leptonic $B$ decays observed by LHCb. Solving the $B$ physics anomalies predicts the presence of a dijet or $t\bar t$ resonance around 1 TeV just below the sensitivity of LHC run 1. We discuss the prospects to probe the models at run 2 of the LHC. As a side product, we identify several gaps in the searches for vector-like quarks at hadron colliders, that could be closed by reanalyzing existing LHC data.Comment: 74 pages, 21 figures. v2: references added, discussion in 3.2.6 extende

Electroweak symmetry breaking and collider signatures in the next-to-minimal composite Higgs model

We conduct a detailed numerical analysis of the composite pseudo-Nambu-Goldstone Higgs model based on the next-to-minimal coset $\text{SO}(6)/\text{SO}(5)\cong\text{SU}(4)/\text{Sp}(4)$, featuring an additional SM singlet scalar in the spectrum, which we allow to mix with the Higgs boson. We identify regions in parameter space compatible with all current experimental constraints, including radiative electroweak symmetry breaking, flavour physics, and direct searches at colliders. We find the additional scalar, with a mass predicted to be below a TeV, to be virtually unconstrained by current LHC data, but potentially in reach of run 2 searches. Promising indirect searches include rare semi-leptonic $B$ decays, CP violation in $B_s$ mixing, and the electric dipole moment of the neutron.Comment: 32 pages + appendices, 9 figures. v2: minor clarifications, matches the JHEP versio

Violation of lepton flavour universality in composite Higgs models

We investigate whether the $2.6\sigma$ deviation from lepton flavour universality in $B^+\to K^+\ell^+\ell^-$ decays recently observed at the LHCb experiment can be explained in minimal composite Higgs models. We show that a visible departure from universality is indeed possible if left-handed muons have a sizable degree of compositeness. Constraints from $Z$-pole observables are avoided by a custodial protection of the muon coupling. The deficit in the invisible $Z$ width at LEP is explained in the same region of parameters.Comment: 5 pages, 2 figures. v4: discussion of invisible Z width adde

Status of the B→K∗μ+μ−B\to K^*\mu^+\mu^- anomaly after Moriond 2017

Motivated by recent results by the ATLAS and CMS collaborations on the angular distribution of the $B \to K^* \mu^+\mu^-$ decay, we perform a state-of-the-art analysis of rare $B$ meson decays based on the $b \to s \mu \mu$ transition. Using standard estimates of hadronic uncertainties, we confirm the presence of a sizable discrepancy between data and SM predictions. We do not find evidence for a $q^2$ or helicity dependence of the discrepancy. The data can be consistently described by new physics in the form of a four-fermion contact interaction $(\bar s \gamma_\alpha P_L b)(\bar \mu \gamma^\alpha \mu)$. Assuming that the new physics affects decays with muons but not with electrons, we make predictions for a variety of theoretically clean observables sensitive to violation of lepton flavour universality.Comment: 20 pages, 8 figures, 3 tables. v3: numerics updated using v2 of arXiv:1606.04731. Conclusions unchanged. Matches published version. Example script available at https://github.com/DavidMStraub/paper-bkstarmumu-ans

Computer-assisted ex vivo, normothermic small bowel perfusion

Background: In the present study, a technique for computer-assisted, normothermic, oxygenated, ex vivo, recirculating small bowel perfusion was established as a tool to investigate organ pretreatment protocols and ischemia/reperfusion phenomena. A prerequisite for the desired setup was an organ chamber for ex vivo perfusion and the use of syngeneic whole blood as perfusate. Methods: The entire small bowel was harvested from Lewis rats and perfused in an organ chamber ex vivo for at least 2 h. The temperature was kept at 37 degrees C in a water bath. Three experimental groups were explored, characterized by different perfusion solutions. The basic perfusate consisted of syngeneic whole blood diluted with either NaCl, Krebs' solution or Krebs' solution and norepinephrine to a hematocrit of 30%. In addition, in each group l-glutamine was administered intraluminally. The desired perfusion pressure was 100 mm Hg which was kept constant with a computer-assisted data acquisition software, which measured an-line pressure, oxygenation, flow, temperature and pH and adjusted the pressure by changing the flow via a peristaltic pump. The viability of the preparation was tested by measuring oxygen consumption and maltose absorption, which requires intact enzymes of the mucosal brush border to break down maltose into glucose. Results: Organ perfusion in group 1 (dilution with NaCl) revealed problems such as hypersecretion into the bowel lumen, low vascular resistance and no maltose uptake. In contrast a viable organ could be demonstrated using Krebs' solution as dilution solution. The addition of norepinephrine led to an improved perfusion over the entire perfusion period. Maltose absorption was comparable to tests conducted with native small bower. Oxygen consumption was stable during the 2-hour perfusion period. Conclusions: The ex vivo perfusion system established enables small bowel perfusion for at least 2 h. The viability of the graft could be demonstrated. The perfusion time achieved is sufficient to study leukocyte/lymphocyte interaction with the endothelium of the graft vessels. In addition, a viable small bowel, after 2 h of ex vivo perfusion, facilitates testing of pretreatment protocols for the reduction of the immunogenicity of small bowel allografts. Copyright (C) 2000 S. Karger AG, Basel

The effect of low-dose proteasome inhibition on pre-existing atherosclerosis in LDL receptor-deficient mice

Dysfunction of the ubiquitin-proteasome system (UPS) has been implicated in atherosclerosis development. However, the nature of UPS dysfunction has been proposed to be specific to certain stages of atherosclerosis development, which has implications for proteasome inhibition as a potential treatment option. Recently, low-dose proteasome inhibition with bortezomib has been shown to attenuate early atherosclerosis in low-density lipoprotein receptor-deficient (LDLR(-/-)) mice. The present study investigates the effect of low-dose proteasome inhibition with bortezomib on pre-existing advanced atherosclerosis in LDLR(-/-) mice. We found that bortezomib treatment of LDLR(-/-) mice with pre-existing atherosclerosis does not alter lesion burden. Additionally, macrophage infiltration of aortic root plaques, total plasma cholesterol levels, and pro-inflammatory serum markers were not influenced by bortezomib. However, plaques of bortezomib-treated mice exhibited larger necrotic core areas and a significant thinning of the fibrous cap, indicating a more unstable plaque phenotype. Taking recent studies on favorable effects of proteasome inhibition in early atherogenesis into consideration, our data support the hypothesis of stage-dependent effects of proteasome inhibition in atherosclerosis