Context Is Key, Limits Are Crucial: Understanding the Scope of Implied Rights of Action for Rescission of Investment Contracts under the Investment Company Act of 1940

The article discusses the scope of the implied rights of action covering the rescission of investment contracts under the Investment Company Act of 1940 (ICA) in the U.S. to prevent fraud and mismanagement

Chromosome loops arising from intrachromosomal tethering of telomeres occur at high frequency in G1 (non-cycling) mitotic cells: Implications for telomere capture

BACKGROUND: To investigate potential mechanisms for telomere capture the spatial arrangement of telomeres and chromosomes was examined in G1 (non-cycling) mitotic cells with diploid or triploid genomes. This was examined firstly by directly labelling the respective short arm (p) and long arm subtelomeres (q) with different fluorophores and probing cell preparations using a number of subtelomere probe pairs, those for chromosomes 1, 3, 4, 5, 6, 7, 9, 10, 12, 17, 18, and 20. In addition some interstitial probes (CEN15, PML and SNRPN on chromosome 15) and whole chromosome paint probes (e.g. WCP12) were jointly hybridised to investigate the co-localization of interphase chromosome domains and tethered subtelomeres. Cells were prepared by omitting exposure to colcemid and hypotonic treatments. RESULTS: In these cells a specific interphase chromosome topology was detected. It was shown that the p and q telomeres of the each chromosome associate frequently (80% pairing) in an intrachromosomal manner, i.e. looped chromosomes with homologues usually widely spaced within the nucleus. This p-q tethering of the telomeres from the one chromosome was observed with large (chromosomes 3, 4, 5), medium sized (6, 7, 9, 10, 12), or small chromosomes (17, 18, 20). When triploid nuclei were probed there were three tetherings of p-q subtelomere signals representing the three widely separated looped chromosome homologues. The separate subtelomere pairings were shown to coincide with separate chromosome domains as defined by the WCP and interstitial probes. The 20% of apparently unpaired subtelomeric signals in diploid nuclei were partially documented to be pairings with the telomeres of other chromosomes. CONCLUSIONS: A topology for telomeres was detected where looped chromosome homologues were present at G1 interphase. These homologues were spatially arranged with respect to one-another independently of other chromosomes, i.e. there was no chromosome order on different sides of the cell nuclei and no segregation into haploid sets was detected. The normal function of this high frequency of intrachromosomal loops is unknown but a potential role is likely in the genesis of telomere captures whether of the intrachromosomal type or between non-homologues. This intrachromosomal tethering of telomeres cannot be related to telomeric or subtelomeric sequences since these are shared in varying degree with other chromosomes. In our view, these intrachromosomal telomeric tetherings with the resulting looped chromosomes arranged in a regular topology must be important to normal cell function since non-cycling cells in G1 are far from quiescent, are in fact metabolically active, and these cells represent the majority status since only a small proportion of cells are normally dividing

Retirement celebration for Rev. John Kucharik. Jan 24, 1982

Rev. John Kucharik, who had faithfully served St. Luke\u27s for almost 15 years after the death of the congregation\u27s first pastor in 1967, was honored by the congregation with a fellowship dinner served in Founders Hall following the two morning worship services on Sunday, January 24, 1982. The scripture chosen as the theme for the day was Philippians 4:4 ( Rejoice in the Lord always, and again I say, rejoice! ) because it exemplified Pastor Kucharik\u27s entire life of ministry. Flowers for the church altar were provided by the church and school staff; the homily was preached by SELC District President, Dr. Albert Marcis; Pastors Daniel Estok and Carl Toelke served as liturgists; Judy Duda served as organist and Ruth Wiedenmann directed the church choir for the worship services. Pastor Kucharik continued to serve as a Visiting Pastor for Trinity Lutheran Church in Orlando for several years after retiring from St. Luke\u27s and also ministered to Lutheran Haven residents as Chaplain

Vision 87 75th Anniversary Membership Directory. 1987

A commemorative St. Luke\u27s membership directory was published in 1987, in observance of the 75th Anniversary of the congregation that year. In addition to a brief history,recapturing some of the highlights of those 75 years, the directory contained a listing of congregational ministries and activities and photos of all the members at that time

IC 021 Guide to St. Luke\u27s Episcopal Hospital Records, 1959-2011

St. Luke’s Episcopal Hospital, now known as Baylor St Luke’s Medical Center in CHI St. Luke’s Health Center was established in 1962 by Denton A Cooley. The materials are generally in good condition. The collection contains newsletters, directories and rosters, bylaws, brochures, and 6mm films. See more at IC 021

Evolution of acid nociception: ion channels and receptors for detecting acid.

Nociceptors, i.e. sensory neurons tuned to detect noxious stimuli, are found in numerous phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, e.g. heat, cold, pressure and chemicals, such as acid. Owing to the ability of protons to have a profound effect on ionic homeostasis and damage macromolecular structures, it is no wonder that the ability to detect acid is conserved across many species. To detect changes in pH, nociceptors are equipped with an assortment of different acid sensors, some of which can detect mild changes in pH, such as the acid-sensing ion channels, proton-sensing G protein-coupled receptors and several two-pore potassium channels, whereas others, such as the transient receptor potential vanilloid 1 ion channel, require larger shifts in pH. This review will discuss the evolution of acid sensation and the different mechanisms by which nociceptors can detect acid. This article is part of the Theo Murphy meeting issue 'Evolution of mechanisms and behaviour important for pain'.Versus Arthritis (RG21973) University of Cambridge BBSRC Doctoral Training Programme (BB/M011194/1

“Rather Death than the Montagne”: Roots of Federalist Revolts of 1793 in Revolutionary France

In 1793, conflicts between factions of the revolutionary government of France, called the National Convention, led to riots. These conflicts centered around the ability to influence and control the National Convention and have been commonly referred to as the Federalist revolts by historians, with “Federalism” referring to the principles of state sovereignty as opposed to a more central government. The historiography of the Federalist revolts regarding the level of influence of Parisian politics over local movements, has shifted throughout the 20th century. This paper looks at this shift and analyzes the extent of how different factors affected the outcome of revolt, with for example certain cities seemingly more influenced by political events in Paris, while others had very powerful local roots