Will graduating medical students prefer to practise in rural communities?

Background: The shortage of doctors and their maldistribution between urban and rural areas contribute to inequitable health care delivery. Strategies are being sought by the government and universities to address these challenges. At the Nelson R Mandela School of Medicine of the University of KwaZulu-Natal the admissions policy ensures greater access to rural students and curricular interventions have been introduced to increase an awareness of the plight of vulnerable communities. This study attempted to ascertain the career intentions of final-year medical students and the influence of area of origin and gender on the location of their proposed future practice.Methods: The 2005 final-year cohort was surveyed by means of an anonymous questionnaire. Demographic information, area of origin and career intentions were canvassed. Students of rural origin were identified as those who matriculated from rural schools and lived more than 200 km from the nearest city. The data were analysed descriptively.Results: Female and rural students accounted for 63% and 11% of the sample respectively. Women were less likely than men to practise in rural areas. Thirty-five per cent indicated a preference for a public government service career as opposed to a private medical (26%) career. Slightly more than 13.7% (n = 26) of the cohort wished to pursue practice or  postgraduate careers overseas. Nearly 62% (n = 90) of the students in the current cohort received government subsidies for their studies.Conclusions: The increased intake of students from rural origin and curricular attempts to increase social awareness of vulnerable rural communities are inadequate to alter the perceptions of medical graduates towards rural practice. While government initiatives and medical schools are starting to work together to service rural communities, alternative strategies need to be explored to entice physicians to rural practice

Community views on active case finding for tuberculosis in low- and middle-income countries: a qualitative evidence synthesis

Objectives: This is a protocol for a Cochrane Review (qualitative). The objectives are as follows:. To synthesize community views on tuberculosis active case finding programmes in low- and middle-income countries. Review question In areas of the world where tuberculosis is common, what views do communities and high-risk populations hold about tuberculosis active case finding programmes?. Target audience Policy groups at global, national and local levels considering, recommending, designing, or implementing active case finding programmes. Feasibility of programmes, as assessed by health staff, will not be part of this review

New changing look case in NGC 1566

We present a study of optical, UV and X-ray light curves of the nearby changing look active galactic nucleus in the galaxy NGC 1566 obtained with the Neil Gehrels Swift Observatory and the MASTER Global Robotic Network over the period 2007-2018. We also report on our optical spectroscopy at the South African Astronomical Observatory with the 1.9-m telescope on the night 2018 August 2-3. A substantial increase in X-ray flux by 1.5 orders of magnitude was observed following the brightening in the UV and optical bands during the last year. After a maximum was reached at the beginning of 2018 July the fluxes in all bands decreased with some fluctuations. The amplitude of the flux variability is strongest in the X-ray band and decreases with increasing wavelength. Low-resolution spectra reveal a dramatic strengthening of the broad emission as well as high-ionization [Fe X] 6374 angstrom lines. These lines were not detected so strongly in the past published spectra. The change in the type of the optical spectrum was accompanied by a significant change in the X-ray spectrum. All these facts confirm NGC 1566 to be a changing look Seyfert galaxy

The post-maximum behaviour of the changing-look Seyfert galaxy NGC 1566

We present results of the long-term multiwavelength study of optical, UV, and X-ray variability of the nearby changing-look (CL) Seyfert NGC 1566 observed with the Swift Observatory and the MASTER Global Robotic Network from 2007 to 2019. We started spectral observations with South African Astronomical Observatory 1.9-m telescope soon after the brightening was discovered in July 2018 and present here the data for the interval between 2018 August and 2019 September. This paper concentrates on the remarkable post-maximum behaviour after 2018 July when all bands decreased with some fluctuations. We observed three significant re-brightenings in the post-maximum period during 2018 November 17-2019 January 10, 2019 April 29-2019 June 19, and 2019 July 27-2019 August 6. An X-ray flux minimum occurred in 2019 March. The UV minimum occurred about 3 months later. It was accompanied by a decrease of the L-UV/LX-ray ratio. New post-maximum spectra covering (2018 November 31-2019 September 23) show dramatic changes compared to 2018 August 2, with fading of the broad lines and [Fe X] lambda 6374 until 2019 March. These lines became somewhat brighter in 2019 August-September. Effectively, two CL states were observed for this object: changing to type 1.2 and then returning to the low state as a type 1.8 Sy. We suggest that the changes are due mostly to fluctuations in the energy generation. The estimated Eddington ratios are about 0.055 per cent for minimum in 2014 and 2.8 per cent for maximum in 2018

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer

background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer. methods: The tumour microenvironment was examined using measures of the inflammatory infiltrate (Klintrup-Makinen (KM) grade and Immunoscore), tumour stroma percentage (TSP) and tumour budding. The systemic inflammatory environment was examined using modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR). A 5-year CSS was examined. results: A total of 331 patients were included. Increasing T stage was associated with colonic primary, N stage, poor differentiation, margin involvement and venous invasion (P<0.05). T stage was significantly associated with KM grade (P=0.001), Immunoscore (P=0.016), TSP (P=0.006), tumour budding (P<0.001), and elevated mGPS and NLR (both P<0.05). In patients with T3 cancer, N stage stratified survival from 88 to 64%, whereas Immunoscore and budding stratified survival from 100 to 70% and from 91 to 56%, respectively. The Glasgow Microenvironment Score, a score based on KM grade and TSP, stratified survival from 93 to 58%. conclusions: Although associated with increasing T stage, local and systemic tumour environment characteristics, and in particular Immunoscore, budding, TSP and mGPS, are stage-independent determinants of survival and may be utilised in the staging of patients with primary operable colorectal cancer

Tuberculosis Contact Screening and Isoniazid Preventive Therapy in a South Indian District: Operational Issues for Programmatic Consideration

BACKGROUND: Under India's Revised National Tuberculosis Control Programme (RNTCP), all household contacts of sputum smear positive Pulmonary Tuberculosis (PTB) patients are screened for TB. In the absence of active TB disease, household contacts aged <6 years are eligible for Isoniazid Preventive Therapy (IPT) (5 milligrams/kilogram body weight/day) for 6 months. OBJECTIVES: To estimate the number of household contacts aged <6 years, of sputum smear positive PTB patients registered for treatment under RNTCP from April to June'2008 in Krishna District, to assess the extent to which they are screened for TB disease and in its absence initiated on IPT. METHODS: A cross sectional study was conducted. Households of all smear positive PTB cases (n = 848) registered for treatment from April to June'2008 were included. Data on the number of household contacts aged <6 years, the extent to which they were screened for TB disease, and the status of initiation of IPT, was collected. RESULTS: Households of 825 (97%) patients were visited, and 172 household contacts aged <6 years were identified. Of them, 116 (67%) were evaluated for TB disease; none were found to be TB diseased and 97 (84%) contacts were initiated on IPT and 19 (16%) contacts were not initiated on IPT due to shortage of INH tablets in peripheral health centers. The reasons for non-evaluation of the remaining eligible children (n = 56, 33%) include no home visit by the health staff in 25 contacts, home visit done but not evaluated in 31 contacts. House-hold contacts in rural areas were less likely to be evaluated and initiated on IPT [risk ratio 6.65 (95% CI; 3.06-14.42)]. CONCLUSION: Contact screening and IPT implementation under routine programmatic conditions is sub-optimal. There is an urgent need to sensitize all concerned programme staff on its importance and establishment of mechanisms for rigorous monitoring

A Decline in New HIV Infections in South Africa: Estimating HIV Incidence from Three National HIV Surveys in 2002, 2005 and 2008

Three national HIV household surveys were conducted in South Africa, in 2002, 2005 and 2008. A novelty of the 2008 survey was the addition of serological testing to ascertain antiretroviral treatment (ART) use.We used a validated mathematical method to estimate the rate of new HIV infections (HIV incidence) in South Africa using nationally representative HIV prevalence data collected in 2002, 2005 and 2008. The observed HIV prevalence levels in 2008 were adjusted for the effect of antiretroviral treatment on survival. The estimated "excess" HIV prevalence due to ART in 2008 was highest among women 25 years and older and among men 30 years and older. In the period 2002-2005, the HIV incidence rate among men and women aged 15-49 years was estimated to be 2.0 new infections each year per 100 susceptible individuals (/100pyar) (uncertainty range: 1.2-3.0/100pyar). The highest incidence rate was among 15-24 year-old women, at 5.5/100pyar (4.5-6.5). In the period 2005-2008, incidence among men and women aged 15-49 was estimated to be 1.3/100 (0.6-2.5/100pyar), although the change from 2002-2005 was not statistically significant. However, the incidence rate among young women aged 15-24 declined by 60% in the same period, to 2.2/100pyar, and this change was statistically significant. There is evidence from the surveys of significant increases in condom use and awareness of HIV status, especially among youth.Our analysis demonstrates how serial measures of HIV prevalence obtained in population-based surveys can be used to estimate national HIV incidence rates. We also show the need to determine the impact of ART on observed HIV prevalence levels. The estimation of HIV incidence and ART exposure is crucial to disentangle the concurrent impact of prevention and treatment programs on HIV prevalence