Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Additional file 3: Figure S3. Regulation of genes of Arrhythmogenic right ventricular cardiomyopathy pathway during senescence induction in HFF strains Genes of the “Arrhythmogenic right ventricular cardiomyopathy” pathway which are significantly up- (green) and down- (red) regulated (log2 fold change >1) during irradiation induced senescence (120 h after 20 Gy irradiation) in HFF strains. Orange color signifies genes which are commonly up-regulated during both, irradiation induced and replicative senescence

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

DETERMINATION OF SOLUTION STRUCTURES OF BINUCLEAR COPPER(II) COMPLEXES

A simple and efficient method for the determination of solution structures of weakly coupled binuclear copper(II) complexes is described. The technique involves the combination of molecular mechanics and EPR spectroscopy and has been applied to the binuclear copper(II) complexes of 5,5'-bis(3,7-dehydro-3,7-diazanonane-4,6-dione-1,9-diamine) (L1), 5,5'-bis(3,7-diazanonane-1,9-diamine) (L2), and 5-methyl-5-nitro-3,7-diazanonanedioate (L3). The complexes [Cu2L1].10H2O and [Cu2L2](ClO4)4 were also characterized by X-ray crystallography. (Cu2L1].10H2O: space group P1BAR; a = 7.669 (2), b = 8.757 (3), c = 10.596 (2) angstrom; alpha = 79.57 (3), beta = 83.36 (2), gamma = 89.17 (3)-degrees. [Cu2L2] (ClO4)4: space group P3(2)21; a = 13.671 (2), b = 13.671 (2), c = 13.929 (2) angstrom. There is excellent agreement between the X-ray crystal structures and the structures predicted by molecular mechanics and EPR spectroscopy, Electrochemical properties of the binuclear complexes are also reported