Efficacy of non-surgical periodontal therapy in reducing periodontal indexes in kidney-transplant patients

Efficacy of non-surgical periodontal therapy in reducing periodontal indexes in kidney-transplant patients. I. Casula, L. Zanardini*, M. Bianchi, V. Spotti, E. Marchesini Department of Medical and Surgical Specialties and Public Health Dentale - Dental School – University of Brescia, Italy Aim: kidney-transplant patient must take cyclosporine-A and calcium channel blockers chronically. Both medicines involve a gingival overgrowth (G.O.) as a collateral effect and this is due to their dosage: it appears 1-3 months after the beginning of the therapy. The prevalence of the G.O. is 84%. The G.O. originates from anterior interdental papilla and it appears as a red and soft tumefaction, that becomes more fibrinous as time goes by. The G.O. takes place in apical-coronal verse and also in vestibular-lingual verse and it looks like a gingival hypertrophy and hyperplasia, which is due to an abnormal increase of the number of fibroblasts into gingival connective tissue. The G.O. involves a great aggregation of extracellular Matrix, or less degradation of it, or both these processes simultaneously. The G.O. leads to the formation of pseudopockets, which interfere with the correct oral hygiene practices. This condition gives rise to mature plaque retention , that leads to infection, inflammation and the increase of the G.O. This condition becomes worse because of bad pre-transplant oral hygiene state. The aim of this study is to estimate the efficacy of non-surgical periodontal therapy in reducing the G.O. in kidney-transplant patient. Materials and methods: a sample of 32 simple random kidney transplant subjects was enrolled in this study (mean age: 58,44; range: 33-81, 21 m., 11f.). All of them were taking cyclosporine A and calcium channel blockers. Patients taking idantoine, pregnant women, patients suffering from diabetes mellitus or people who have undergone gingival surgery were excluded. The study started on November 2012 and finished on September 2013. Periodontal indexes and Professional oral hygiene practices were performed by the same dental hygienist. The plaque, calculus, bleeding, G.O. and probing depth indexes were evaluated at T0, T1, T2, T3 (at 0, 2, 4, 6 months respectively). Every time the same oral hygiene protocol was applied: non-surgical periodontal therapy with ultrasonic instruments above and below the gum. Results: 787 teeth analysed and 4722 periodontal sites probed. Plaque index (PI), calculus index (CI) and bleeding index (BoP) show significant statistical reduction (p<0,0001). T-test was used for statistic analysis. PI at T0=82,09%, at T3=29,89%/ CI at T0=53,44%, at T3=23,70%/ BoP at T0=71,98%, at T3=26,18%. Probing depth (PD), at six-monthly control , shows a significant statistical reduction (p<0,0001). PD 1-3 mm at T0=16,58%, at T3=30,45%. PD 4-6mm at T0=74,06%, at T3=64,70%. PD 7-9 mm at T0=9,36%, at T3=4,85%. G.O. At T0=54,93%, at T3=44,98%, with a significant statistical reduction (p<0,0001). Conclusions: the applied oral hygiene protocol is simple but effective in reducing drug-induced gingival overgrowth in kidney-transplant patient taking Cyclosporine-A. These clinic results assure a better oral health, improving the quality of life form an aesthetic and functional point of view

Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Background: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated vs. non-vaccinated patients, both hospitalised with SARS-CoV-2 infection in 3 major hospitals in Northern Italy. Methods: Data collection was retrospective, and paper and electronic medical records of adult patients with a diagnosed SARS-CoV-2 infection were pseudo-anonymised and analysed. Vaccinated and non-vaccinated individuals were manually paired, using a predetermined matching criterion (similar age, gender, and date of hospitalisation). Demographic, clinical, treatment, and outcome data were compared between groups differing by vaccination status using Pearson’s Chi-square and Mann-Whitney tests. Moreover, multiple logistic regression analyses were performed to assess the impact of vaccination status on ICU admission or intra-hospital mortality. Results: Data from 360 patients were collected. Vaccinated patients presented with a higher prevalence of relevant comorbidities, like kidney replacement therapy or haematological malignancy, despite a milder clinical presentation at the first evaluation. Non-vaccinated patients required intensive care more often than their vaccinated counterparts (8.8% vs. 1.7%, p = 0.002). Contrariwise, no difference in intra-hospital mortality was observed between the two groups (19% vs. 20%, p = 0.853). These results were confirmed by multivariable logistic regressions, which showed that vaccination was significantly associated with decreased risk of ICU admission (aOR=0.172, 95%CI: 0.039–0.542, p = 0.007), but not of intra-hospital mortality (aOR=0.996, 95%CI: 0.582–1.703, p = 0.987). Conclusions: This study provides real-world data on vaccinated patients hospitalised with COVID-19 in Northern Italy. Our results suggest that COVID-19 vaccination has a protective role in individuals with higher risk profiles, especially regarding the need for ICU admission. These findings contribute to our understanding of SARS-CoV-2 infection outcomes among vaccinated individuals and emphasise the importance of vaccination in preventing severe disease, particularly in those countries with lower first-booster uptake rates